Fig. 5.

Ciona disease orthologs. (A) Human disease associated genes represented by Ciona intestinalis orthologs and full-ORF clones. Numbers of Ciona orthologs and full-ORF clones are depicted for five human diseases affecting neural or muscular tissue. Disease associated genes and disease complexes are from an integrated interactome (Lage et al., 2008) and contain potentially conserved functional modules to be analysed in simpler Ciona embryos. (B) Conservation of functionally relevant domains in Ciona despite little overall sequence conservation. Dotpath (EMBOSS) of human BACE-1 (GI:6912266) to orthologous protein sequences of zebrafish (GI:45387815), Ciona (KH.L156.2.v4.A.SL1-2) and nematode (GI:17549909).