Fig. 10.

Tract-based spatial statistic (TBSS) results demonstrating a reduction in fractional anisotropy in the MND population compared to controls. a) Significant voxels (p < 0.05) are overlaid on the template FA skeleton. Differences were observed in the corpus callosum region associated with the motor cortex, with no voxels being significant in the corticospinal tract. b) When the p-value threshold is relaxed to 0.2, supra-threshold voxels are observed in the corticospinal tract; however at this threshold other regions not typically associated with MND are also supra-threshold. For both images the orientation shown is coronal (top left), sagittal (top right) and axial (bottom left).