FIGURE 1.
The HsBBS91–407 N-terminal domain is a WD40 β-propeller. A, schematic diagram of the domain architecture of HsBBS9 with the relevant domain boundaries numbered. The N-terminal β-propeller domain, solved here, is colored white to blue from N to C terminus. Following the β-propeller is a γ-adaptin ear (GAE) β-sandwich domain, a mixed α/β platform domain, and a C-terminal α-helical domain (10). B, graphic representation of the HsBBS91–407 β-propeller viewed from the face and, as a result of a 90° rotation, the side. The structure is colored white to blue from N to C terminus as in A. β-Strands are depicted as arrows, helices are depicted as ribbons, and loops are depicted as lines. The individual blades are labeled. C, detailed schematic of HsBBS9 tertiary structure, colored as in A.