FIGURE 7.

The HsBBS9_1–407 β-propeller forms a homodimer in the crystal lattice. A, overview of the HsBBS9_1–407 homodimer. Each NCS copy (one shown in blue, the other shown in gray) is depicted as a graphic representation. Inset left (solid line), close-up view of the β-strand domain swap. Inset right (dotted line), close-up view of the C-terminal loop domain swap, with interacting residues shown as sticks. Black dotted lines depict hydrogen bonds. The inset views are rotated relative to the overview for clarity. B, conservation mapped, from low (white) to high (orange), onto a solvent-accessible surface representation of HsBBS9_1–407 in the same orientation as the gray copy in A. The binding site of the symmetry mate is outlined (black). A 90° rotation of this starting orientation is shown, for clarity.