Figure - PMC

Skip to main content

An official website of the United States government

Here's how you know

Here's how you know

Official websites use .gov
A .gov website belongs to an official government organization in the United States.

Secure .gov websites use HTTPS
A lock ( ) or https:// means you've safely connected to the .gov website. Share sensitive information only on official, secure websites.

View full-text article in PMC

. 2015 Jun 23;290(32):19597–19613. doi: 10.1074/jbc.M115.655654

Search in PMC
Search in PubMed
View in NLM Catalog
Add to search

© 2015 by The American Society for Biochemistry and Molecular Biology, Inc.

PMC Copyright notice

FIGURE 6. — Overall structural features of Epa6A and Epa1A. A, overall fold of Epa6A (blue) shows a β-sandwich comparable with that of Epa1A (gray). The complex structures of Epa6A and Epa1A show a bound T-antigen ligand (Galβ1–3GalNAc, yellow) complexed by a calcium ion (orange) via a DcisD motif that is highly conserved in fungal adhesins. B, selectivity and affinity in ligand binding is achieved by two calcium binding loops (CBL1 and CBL2; brown) in combination with three flexible loops, L1 to L3 (green). L1 and L2 are connected by a disulfide bridge via Cys-78 and Cys-119, which shields the binding pocket from surrounding solvent. L3 contains a tryptophan residue (green) that is highly conserved in Epa adhesins and is essential for ligand binding.