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. 2015 Jun 21;290(32):19666–19680. doi: 10.1074/jbc.M115.660043

TABLE 2.

Maribavir susceptibility phenotypes of UL97 mutant viruses

Straina UL97 genotypeb Maribavir EC50c Replicatesd
μm
T3261 Wild type 0.12 ± 0.03 22
T3260 C151G/C428G/C693G 0.03 ± 0.01 13
T3719 C151G/W368A/C428G/C693G 35 ± 7 12
T3727 W368A 27 ± 7 12

a Serial number of recombinant CMV strain derived by transfection of bacterial artificial chromosome into fibroblasts.

b Mutation induced into bacterial artificial chromosome and recombinant virus.

c Mean drug concentration (μm) required to reduce secreted alkaline phosphatase growth by 50% at 6–7 days postinfection.

d Number of assays.