TABLE 2.
Straina | UL97 genotypeb | Maribavir EC50c | Replicatesd |
---|---|---|---|
μm | |||
T3261 | Wild type | 0.12 ± 0.03 | 22 |
T3260 | C151G/C428G/C693G | 0.03 ± 0.01 | 13 |
T3719 | C151G/W368A/C428G/C693G | 35 ± 7 | 12 |
T3727 | W368A | 27 ± 7 | 12 |
a Serial number of recombinant CMV strain derived by transfection of bacterial artificial chromosome into fibroblasts.
b Mutation induced into bacterial artificial chromosome and recombinant virus.
c Mean drug concentration (μm) required to reduce secreted alkaline phosphatase growth by 50% at 6–7 days postinfection.
d Number of assays.