Figure - PMC

Skip to main content

An official website of the United States government

Here's how you know

Here's how you know

Official websites use .gov
A .gov website belongs to an official government organization in the United States.

Secure .gov websites use HTTPS
A lock ( ) or https:// means you've safely connected to the .gov website. Share sensitive information only on official, secure websites.

View full-text article in PMC

. 2015 Aug 7;9:195. doi: 10.3389/fnbeh.2015.00195

Search in PMC
Search in PubMed
View in NLM Catalog
Add to search

Copyright © 2015 Riga, Theijs, De Vries, Smit and Spijker.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

PMC Copyright notice

SDPS triggers motivational overdrive toward a sucrose reward; guanfacine attenuates enhanced motivation. (A) The motivation to acquire a sucrose reward was examined in 6 treatment-free PR training sessions (highlighted; B,C). (B) SDPS increased responding during both the pre- (PR3–4) and post- (PR6–7) treatment sessions, and no carry-over effects of guanfacine treatment were detected (see E). (C) Break points, depicted as the maximum FR completed when averaging over the four treatment-free sessions, confirmed the SDPS-triggered exaggeration of motivational drive in defeated animals. (D) The effect of guanfacine on PR responding was assessed at PR sessions five and eight using a cross-over treatment administration design (highlighted, E). (E) Guanfacine administration reduced overall PR responding. Independently of treatment regime, the SDPS group showed significantly increased number of responses as compared with controls. ^*P < 0.050; ^**P < 0.010; (B): repeated ANOVA (group effect); (C): One-Way ANOVA (group effect); (E): repeated ANOVA (treatment effect).