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. 2015 Aug 7;5:13079. doi: 10.1038/srep13079

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Copyright © 2015, Macmillan Publishers Limited

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Macroscopic appearance of a decellularized left lobe showing preservation of the vascular tree (a), translucent color (b) and a complete human liver (c). Histological comparison (10X and 40X magnification, left panel and right panel, respectively) of fresh liver (FL) and decellularized liver (DL) by Hematoxylin and Eosin (H&E) (d), Sirius Red (SR) (e) and Elastin Von Gieson EVG (f) staining demonstrating removal of cells and preservation of collagen and elastin in DL. Scale bar for 10X magnification: 200 μm and 40X: 50 μm. DNA quantification demonstrated significant DNA reduction from 1425.23 ± 261.37 ng/mg in FL to 47.91 ± 5.82 ng/mg in DL (g). Collagen significantly increased from 5.860726 ± 1.417547 μg/mg in FL to 90.85345 ± 14.16523 μg/mg in DL scaffolds (h). Elastin quantification demonstrated a significant decrease from 34.56827 ± 5.102387 μg/mg to 7.073619 ± 0.434233 μg/mg in in DL scaffolds (i).