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. 2015 Jun 4;11(10):1503–1510. doi: 10.1016/j.celrep.2015.05.016

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© 2015 The Authors

This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/).

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Ddit3 Remodels the GMP Transcriptional Landscape around Gata2

(A) Transcriptional networks of GMPs transduced with CSIEm and Ddit3 and after 2-day culture under multilineage differentiation conditions. Network inference and representation are as in Figure 2. Highlighted in color are differential regulatory hubs (Gata2, Csf3r, and Mpo); their connectivity is quantified in Figure S4A.

(B) GSEA of early progenitor-affiliated signatures in the transcriptional programs of CSIem- and Ddit3-transduced GMPs is shown.

(C) Diagram shows Ddit3-driven lineage remodeling of GMPs.

(D) Connectivity of the differential regulatory hubs in (A) upon culture of Ddit3-transduced GMPs. Networks are represented in (A) and Figure S4D.

(E) GSEA of Gata2 targets in CSIem- and Ddit3-transduced GMPs. Transduced cells in (B, D, and E) were cultured for 2 days under multilineage differentiation conditions.