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. 2015 Jun 4;11(10):1577–1590. doi: 10.1016/j.celrep.2015.05.018

Figure 3.

Figure 3

The Expression of Markers for Tip Cell Specification Is Not Impaired in Nrp1 Mutants

(A and B) qPCR expression analysis of Nrp1 (A) and Pecam (B), normalized to Actb in E11.5 hindbrains of the indicated genotypes (n = 4 each); expression levels are shown as mean ± SD in mutants relative to wild-type.

(C–H) qPCR expression analysis of the indicated tip cell markers and notch target genes in E11.5 hindbrains of the indicated genotypes (n = 4 each), normalized to Pecam to obtain an objective measure of tip cell marker expression relative to the amount of endothelium; expression levels are shown as mean ± SD in mutants relative to wild-type.

Asterisks indicate p values for homozygous or heterozygous mutants relative to wild-type (∗p < 0.05, ∗∗p < 0.01,∗∗∗p < 0.001), hash tags p values for homozygous relative to heterozygous mutants (#p < 0.05, ##p < 0.01).