Figure 2.

High tidal volumes inure the preterm lung. Six large tidal volumes given by hand at delivery injure the preterm lamb lung and prevent a response to surfactant given at 30 min of age. Redrawn from data in Ref. (31). B. An initial tidal volume of 20 ml/kg results in a high compliance in preterm lambs relative to a low tidal volume of 5 ml/kg, but at 30 min of age, the surfactant response is lost with the high tidal volume. The low tidal volume to 30 min of age allows the lungs to respond to surfactant. Redrawn from data in Ref. (32).