Fig. 3.

Distribution of somatic mutations identified in novel significantly mutated genes. ELF3, KLF5, GNAS and ERBB3 are shown in the context of protein domains as predicted by UniProt, with somatic mutations identified in the exome (closed circle) and validation (open circle) cohorts mapped to each gene. I-IV extracellular domains I, II, III and IV, AT hook & NLS AT-hook domain and nuclear localization signal, C2H2 zinc-finger C2H2 domain, ETS DNA binding domain, GTP GTP nucleotide binding region, PNT pointed domain, SAR serine-rich and aspartic acid-rich domain, TAD transactivation domain, TKD tyrosine kinase domain