Table 5. Wnt pathway components and Wnt-regulated genes influence adult alae formation.
| Strain | n | Normal (%) | Partial (%) | Absent (%) | Rings (%) |
|---|---|---|---|---|---|
| control(RNAi) | 40 | 100 | 0 | 0 | 0 |
| bus-8(RNAi) | 37 | 8 | 30b | 62b | 0 |
| cdk-4(RNAi) | 31 | 36 | 45b | 19b | 0 |
| cki-1(RNAi) | 26 | 26 | 70b | 4 | 0 |
| K10D6.2(RNAi) | 58 | 38 | 58b | 7a | 0 |
| kin-10(ok1751) | 52 | 0 | 10b | 6b | 84b |
| kin-10(RNAi) | 31 | 6 | 7b | 0 | 87b |
| mlt-11(RNAi) | 41 | 2 | 20b | 78b | 0 |
| nhr-23(RNAi) | 34 | 0 | 24b | 76b | 0 |
rrf-3(pk1426) animals were treated with RNAi against the indicated Wnt-regulated genes and examined for defective adult alae formation. The percentage of worms with the indicated types of alae defects is shown. Normal indicates three parallel ridges running along the length of the animal; partial indicates gaps; absent indicates lack of alae; and rings indicates ring-like misformations along the length of the alae.
a
P ≤ 0.05.
b
P ≤ 0.001 (Fisher’s exact test) compared to control (feeding vector alone).