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. 2014 Aug 7;9(1):105–114. doi: 10.1016/j.molonc.2014.07.024

Figure 6.

Figure 6

A schematic representation of caspase 3/7‐PKCδ‐Akt/p38 MAPK signaling pathway in the radiation‐induced apoptotic cells stimulated live tumor cell growth in human pancreatic carcinoma (Panc1) in vitro. After radiation, apoptotic executioner caspase 7 and 3 are cleaved and activated. Activated caspase 7 and 3, eventually via caspase 3, cleave PKCδ to generate a catalytic fragment (CF) and then activate PKCδ. Activated PKCδ CF further phosphorylates and activates Akt or p38 MAPK directly or indirectly and then subsequently causes release of growth factors to stimulate the proliferation of neighboring live tumor cells.