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. 2015 Jul 22;282(1811):20150817. doi: 10.1098/rspb.2015.0817

Figure 2.

Figure 2.

Native SuVIA activates hNaV1.3, hNaV1.4, hNaV1.6 and hNaV1.7. The activity of SuVIA at human sodium channel isoforms NaV1.3, NaV1.4, NaV1.6 and NaV1.7 was assessed using a fluorescent membrane potential assay in stably transfected HEK293 cells. SuVIA was approximately equipotent at hNaV1.3 (EC50 3.98 ± 0.97 nM), hNaV1.4 (EC50 4.99 ± 0.92 nM), hNaV1.6 (EC50 1.27 ± 0.56 nM) and hNaV1.7 (EC50 2.42 ± 0.12 nM). Data are expressed as mean ± s.e.m. from n = 3 wells and is representative of three independent experiments.