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. 2015 Jul 6;12(108):20150234. doi: 10.1098/rsif.2015.0234

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© 2015 The Authors. Published by the Royal Society under the terms of the Creative Commons Attribution License http://creativecommons.org/licenses/by/4.0/, which permits unrestricted use, provided the original author and source are credited.

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Figure 4. — (a) Cartoon representation of a system with two hybrid HKs that share the same Hpt. (b–d) Implementation of different signal processing functions using the system shown in (a); an ‘adder’ as seen experimentally in V. harveyi [36] (b), a Boolean AND gate (c) and a Boolean OR gate (d). Each panel shows the fraction of phosphorylated RR at steady state for different auto-phosphorylation rate constants (i.e. input levels) acting on the two HKs. It is assumed that the two signals are specific for the two HKs (k_1,1, k_1,3 and k_2,1, k_2,3, respectively) and the ratios k_1,1/k_1,3 and k_2,1/k_2,3 are held fixed. The systems shown in (c,d) are bistable, with the blank regions of the surfaces corresponding to unstable regions. For the parameters used, see the electronic supplementary material, table S1.