Table 1.

Summary of pros and cons of both natural and synthetic materials.

	advantages	disadvantages
natural	—biological origin —biocompatibility —presence of adhesive sequences that facilitate cell adhesion and cell differentiation	—inadequate mechanical properties —rapid degradation —variable properties depending on extraction procedure —risk of contamination —high production costs
synthetic	—suitable mechanical properties —highly reproducible chemical and mechanical properties —low production costs —low immune response	—low biocompatibility —risk of biodegradation side effects