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Two independent readouts for quantitating the downstream signaling strength selectively elicited by target- and signal-specific electrophilic modification of a specific upstream target in cells. T-REX-assisted temporally controlled Keap1-specific modifications resulted in blockage of Nrf2 degradation. Accumulating Nrf2 (assessed by western blot) consequently enabled ARE activation (assessed by ARE-luciferase assay).
