Fig. 1.

Vasomotor responses of trout coronary microvessels to increasing concentrations of recombinant interleukin-1β at two experimental temperatures. Vessels tested at 20°C were acutely warmed (over 1 h) from 10°C and then allowed to acclimate to 20°C (∼30 min) before rIL-1β injections were initiated. Dissimilar lower case letters indicate significant differences in the response to the various concentrations of rIL-1β in vessels tested at 10°C, whereas dissimilar capital letters indicate differences in the response to rIL-1β in vessels tested at 20°C. Significant differences between vessels exposed to rIL-1β (10 or 20°C) vs sham injections (at 10°C), at a particular concentration of rIL-1β, are indicated by *P<0.05 and ^‡0.1>P≥0.05. Experimental temperature had no effects on vessel responses to rIL-1β. Note that the series of sham injections (i.e. saline with 0.2 mmol l⁻¹ DTT) did not result in noticeable (i.e. ≤1%) changes in vessel ID. Thus, we considered any change in vessel ID greater than ∼3% (mean change plus 2 s.d. caused by the sham injection) to be biologically significant. All concentrations are in mol l⁻¹.