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. 2015 Aug 7;16(1):586. doi: 10.1186/s12864-015-1774-z

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© Ghandhi et al. 2015

Open Access This article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.

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Fig. 6 — MicroRNA upstream regulators of gene expression. a Heatmap of predicted activation states of microRNA, which may be upstream of gene expression changes observed in the study (shades of orange, positive z-scores; missing values in gray, missing values are shown where the regulator did not have any known relationship with the significantly changed genes at that time). b qPCR validation of selected miRNA species: mmu-miR-16 (⨂), mmu-miR-124 (□), mmu-miR-125 (♦) and mmu-miR-210 (●). Expression peaked at the day 4 time point as predicted from the mRNA data. The complete table with z-scores is in Additional file 6. Each point is the average of 4 samples per condition