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. 2015 Jul 31;71(Pt 8):1684–1698. doi: 10.1107/S1399004715007683

Table 2. Chemical structures and activities of fragment hits.

    T m (C)    
Fragment Chemical structure Without His With His IC50 (mM) Inhibition at 2mM (%)
Chem 79 graphic file with name d-71-01684-scheme1.jpg 0.3 0.1 ND ND
Chem 84 graphic file with name d-71-01684-scheme2.jpg 0.8 1.6 >2 20
Chem 89 graphic file with name d-71-01684-scheme3.jpg 0.4 0.5 >2 39
Chem 744 graphic file with name d-71-01684-scheme4.jpg 0.6 0.1 ND ND
Chem 148 graphic file with name d-71-01684-scheme5.jpg 0.4 0.1 ND ND
Chem 145 graphic file with name d-71-01684-scheme6.jpg 0.3 0.1 ND ND
Chem 149 graphic file with name d-71-01684-scheme7.jpg 0.2 0.2 >2 21
Chem 166 graphic file with name d-71-01684-scheme8.jpg 0.3 0.1 ND ND
Chem 256 graphic file with name d-71-01684-scheme9.jpg 0.1 0.1 ND ND
Chem 262 graphic file with name d-71-01684-scheme10.jpg 0.3 0.1 ND ND
Chem 260 graphic file with name d-71-01684-scheme11.jpg 0.4 0.5 ND ND
Chem 443 graphic file with name d-71-01684-scheme12.jpg 0.3 0.1 ND ND
Chem 475 graphic file with name d-71-01684-scheme13.jpg 0.4 0 ND ND
Chem 707 graphic file with name d-71-01684-scheme14.jpg 0.2 0.4 ND ND
Chem 491 graphic file with name d-71-01684-scheme15.jpg 0.4 0.4 ND ND