Table 4.
Specific urinary proteins listed by association and diagnostic accuracy for CKD and rapid kidney function decline
| Protein | Detected peptides | CKD diagnosis | Rapid kidney function decline | ||||||
|---|---|---|---|---|---|---|---|---|---|
| P value | OR (StdX) | ROC | Rank | P value | OR (StdX) | ROC | Rank | ||
| Collagen alpha-1 (I) chain | 33 | 0.002 | 0.03 | 0.941 | 1 | 0.004 | 0.101 | 0.853 | 3 |
| CD99 antigen | 1 | 0.004 | 0.001 | 0.918 | 2 | 0.028 | 0.008 | 0.832 | 5 |
| Uromodulin | 3 | 0.007 | 0.001 | 0.98 | 3 | 0.019 | 0.025 | 0.846 | 4 |
| Sodium/potassium-transporting ATPase gamma chain | 1 | 0.002 | 0.032 | 0.954 | 4 | 0.016 | 0.002 | 0.93 | 2 |
| Collagen alpha-1 (II) chain | 1 | 0.002 | 0.04 | 0.948 | 5 | 0.001 | 0.063 | 0.93 | 1 |
| Collagen alpha-1 (III) chain | 15 | 0.002 | 0.112 | 0.882 | 6 | 0.013 | 0.195 | 0.837 | 6 |
| Neurosecretory protein VGF | 1 | 0.008 | 37 | 0.876 | 7 | 0.017 | 4.58 | 0.825 | 7 |
| Osteopontin | 2 | 0.016 | 0.018 | 0.863 | 8 | 0.99 | 0.5 | 18 | |
| Collagen alpha-2 (I) chain | 4 | 0.012 | 0.172 | 0.848 | 9 | 0.069 | 0.35 | 0.724 | 13 |
| Transthyretin (Prealbumin) | 2 | 0.086 | n.s. | 0.892 | 10 | 0.062 | 5.51 | 0.82 | 11 |
| Beta-2-microglobulin | 1 | 0.065 | n.s. | 0.859 | 11 | 0.358 | 1.39 | 0.811 | 17 |
| Alpha-2-HS-glycoprotein | 2 | 0.05 | n.s. | 0.84 | 12 | 0.07 | 2.33 | 0.86 | 12 |
| Alpha-1-antitrypsin | 3 | 0.168 | n.s. | 0.871 | 13 | 0.047 | 11.11 | 0.811 | 10 |
| Polymeric-immunoglobulin receptor | 1 | 0.02 | 0.337 | 0.77 | 14 | 0.097 | 0.48 | 0.706 | 16 |
| Apolipoprotein A-I | 1 | 0.172 | n.s. | 0.85 | 15 | 0.047 | 9.45 | 0.822 | 9 |
| Membrane associated progesterone receptor component 1 | 1 | 0.056 | 0.441 | 0.801 | 16 | 0.103 | 0.429 | 0.731 | 14 |
| Albumin | 1 | 0.397 | n.s. | 0.845 | 17 | 0.17 | 1.77 | 0.745 | 15 |
| Fibrinogen alpha chain | 2 | 0.156 | n.s. | 0.722 | 18 | 0.03 | 9 | 0.822 | 8 |
Protein names and number of specific peptides detected from this protein are given. Data are given only for the best peptide per protein. Odds ratios are based on unadjusted logistic regression analysis. Peptides with p values <0.10 or with special interest (albumin) were included. Data show p value and odds ratio for outcome associated with one standard deviation change of protein to improve comparability (logistic regression analysis; OR StdX could not be calculated for all associations). Area under the ROC curve is also given. The separate rankings for CKD diagnosis and rapid kidney function decline (>4 ml/min/1.73 m2 per year) represent the mean ranks for p values, standardized OR and ROC.
n.s. not significant.