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. 2014 Mar 18;2(1):2324709614527812. doi: 10.1177/2324709614527812

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© 2014 American Federation for Medical Research

This article is distributed under the terms of the Creative Commons Attribution 3.0 License (http://www.creativecommons.org/licenses/by/3.0/) which permits any use, reproduction and distribution of the work without further permission provided the original work is attributed as specified on the SAGE and Open Access page (http://www.uk.sagepub.com/aboutus/openaccess.htm).

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Figure 1. — Number of adverse event reports related to POTS/CFS following HPV, Menactra meningococcal polysaccharide diphtheria toxoid conjugate, and Varivax Varicella vaccines in the US Vaccine Adverse Event Reporting System (VAERS) as of February 13, 2013.

The VAERS database³³ was searched using the following criteria: (1) Symptoms: syncope (general, exertional, postural); headaches (including migraines); nausea; chronic fatigue syndrome (including general fatigue); tremors and palpitations; dyspnea (general, exertional, at rest); tachycardia (including tachyarrhythmia, tachycardia paroxysomal, heart rate abnormal, heart rate increased, heart rate irregular); influenza-like illness (including viremia, viral infection); POTS; (2) Vaccine products: HPV, HPV2 (human papilloma virus bivalent), HPV4 (human papilloma virus types 6, 11, 16,1 8); MNQ (Meningococcal vaccine Menactra); Varcel (Varivax-Varicella virus live); (3) Gender (all genders); (4) Age (6 to 29 years; target age group for HPV, Menactra and Varivax vaccines); (5) Territory (the United States); (6) Date vaccinated (2007-2013; HPV vaccine postlicensure period).³⁴ Adverse events related to a particular symptom are reported as percentages of the total number of events reported for the particular vaccine (ie, 14% syncope refers to the 2354 reports of syncope out of a total of 16 644 adverse events associated with the HPV vaccine; the total number of adverse events reported for Varivax and Menactra was 9136 and 8790, respectively).