Table 5.

Associations with mean gene-specific methylation for an interquartile range increase in air pollutant concentration.

	Mean ratioa (95% CI)			Mean differenceb (95% CI)
	F3	ICAM-1	TLR-2	IFN-γ	IL-6
Particle number	0.78 (0.72, 0.85)*	0.97 (0.92, 1.03)	1.00 (0.94, 1.08)	–0.77 (–1.43, –0.11)*	0.59 (–0.55, 1.74)
PM2.5 black carbon	0.90 (0.85, 0.95)*	0.98 (0.95, 1.02)	1.03 (0.98, 1.08)	–0.41 (–0.87, 0.04)	0.76 (–0.03, 1.54)
PM2.5 mass	0.96 (0.93, 1.00)	0.97 (0.94, 1.00)	1.00 (0.97, 1.03)	–0.18 (–0.49, 0.13)	0.33 (–0.19, 0.84)
aMean ratio for F3, ICAM-1, and TLR-2 (multiplicative scale): Because the methylation distributions of F3, ICAM-1, and TLR-2 had a point mass at zero and the residuals’ distribution showed important deviation from a Gaussian density, we assumed a Tweedie distribution (with a log-link) for these outcomes and reported associations on the multiplicative scale. bMean difference for IFN-γ and IL-6 (absolute scale): For the other outcome distributions (i.e., IFN-γ and IL-6 methylation), we assumed a Gaussian distribution for the residuals and presented our results on the additive scale. *Significant at p = 0.05.