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. 2015 Feb 6;123(8):799–805. doi: 10.1289/ehp.1408852

Figure 3.

Figure 3

Blocking TNF signaling with etanercept reduced airway neutrophilia in Notch3 knockout mice. Prior to 24‑hr ozone exposure, mice were treated with a TNF inhibitor (etanercept, 10 mg/kg i.p.) or vehicle (human IgG, 10 mg/kg i.p.). (A) Etanercept pretreatment did not affect BALF protein concentration. (B) Etanercept reduced the ozone-induced influx of neutrophils in Notch3–/– mice. n = 5–10 mice per group. *p < 0.05 compared with respective air controls, and #p < 0.05 between etanercept and vehicle after ozone exposure, by 2-way ANOVA with Tukey’s post hoc tests.