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. 2015 Feb 6;123(8):799–805. doi: 10.1289/ehp.1408852

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Gene expression microarray from whole-lung homogenates identified differentially expressed genes after exposure to ozone. KO, knockout. (A) In WT mice, 116 transcripts were differentially expressed at at least one time point after exposure to ozone compared with air. (B) In Notch3^–/– mice, 739 transcripts were differentially expressed at at least one time point after ozone compared with air. (C) In Notch4^–/– mice, 155 transcripts were differentially expressed at at least one time point after ozone compared with air. p < 0.05, ANOVA with Tukey’s HSD post hoc test and Benjamini-Hochberg multiple testing correction. (D) Number of significantly differentially expressed genes after ozone compared with air. (E) Top 10 significant biological functions from Ingenuity Pathway Analysis and numbers of differentially expressed genes in each category.