Table 4.
Relation of baseline water arsenic (N = 10,846), baseline urinary creatinine-adjusted arsenic (N = 10,549) with adjusted annual changes in diastolic blood pressure (DBP) over 7 years of follow-up.
| Baseline exposure | Range | Model 1 change/year (mmHg) | Model 2 change/year (mmHg) | Model 3 change/year (mmHg) |
|---|---|---|---|---|
| Water arsenic (μg/L) | ||||
| Q1 | < 12 | Reference | Reference | Reference |
| Q2 | 12–62 | 0.44 (0.35, 0.53) | 0.42 (0.33, 0.52) | 0.41 (0.31, 0.50) |
| Q3 | 62–148 | 0.47 (0.38, 0.56) | 0.42 (0.33, 0.52) | 0.41 (0.32, 0.51) |
| Q4 | > 148 | 0.43 (0.34, 0.52) | 0.40 (0.31, 0.49) | 0.39 (0.30, 0.49) |
| Urinary creatinine-adjusted arsenic (μg/g creatinine) | ||||
| Q1 | < 106 | Reference | Reference | Reference |
| Q2 | 106–199 | 0.38 (0.29, 0.48) | 0.37 (0.27, 0.46) | 0.37 (0.27, 0.46) |
| Q3 | 199–352 | 0.40 (0.30, 0.49) | 0.37 (0.27, 0.46) | 0.38 (0.28, 0.47) |
| Q4 | > 352 | 0.49 (0.40, 0.58) | 0.45 (0.35, 0.54) | 0.45 (0.36, 0.55) |
| Abbreviations: Q1, quartile 1; Q2, quartile 2; Q3, quartile 3; Q4, quartile 4. Model 1: controlled for baseline age and sex. Model 2: controlled for model 1 covariates plus BMI, smoking status, educational status, and history of diabetes. Model 3: controlled for model 2 covariates plus change of urinary creatinine-adjusted arsenic since baseline. | ||||