Fig. 4.

CTE subjects with neuritic Aβ plaques (CERAD > 0) had an accelerated tauopathy. a The median CTE stage was significantly greater in CTE subjects with neuritic plaques (*p < 0.001, Mann– Whitney U test). bScatter plots of CTE tau pathology (stage) versus age are shown with separate regression lines for subjects without neuritic plaques (CERAD = 0) and those with neuritic plaques (CERAD > 0). There was a significant correlation between age and CTE stage in subjects without neuritic plaques, but not in CTE subjects with neuritic plaques. The slope of the regression line between age and CTE stage was significantly greater (p = 0.044) in CTE subjects without compared to those with neuritic plaques. c The increase in CTE stage in subjects with neuritic plaques was significant in the 7th decade of life (*p < 0.002, Mann–Whitney U test), while older subjects had similarly elevated CTE stages