Table 3.

Clinical, exposure, and pathological findings in CTE with and without Aβ deposition

	CTE		CTE with DPs			CTE with NPs
	n	Mean ± SEM	n	Mean ± SEM	p*	n	Mean ± SEM	p*
Age at death (year)	55	48.2 ± 2.6	59	71.6 ± 1.4	<0.001	41	73.6 ± 1.4	<0.001
Athletic exposure (year)	51	15.0 ± 1.0	46	15.9 ± 0.9	0.500	31	16.7 ± 1.2	0.22
Concussion no.	48	11.5 ± 3.0	41	24.2 ± 6.6	0.071	28	17.5 ± 5.4	0.99
Age at Sx onset (year)	43	36.2 ± 2.3	42	54.2 ± 2.3	<0.001	30	56.4 ± 2.7	<0.001
	CTE		CTE with DPs			CTE with NPs
	Freq (+/−)		Freq (+/−)	p**	p^	Freq (+/−)	p**	p^
CTE Sx	76 % (37/12)		90 % (43/5)	0.059	0.419	94 % (31/2)	0.028	0.164
Dementia	20 % (10/39)		73 % (35/13)	<0.001	0.013	82 % (27/6)	<0.001	0.012
Cognitive variant	58 % (23/17)		76 % (31/10)	0.067	0.382	76 % (22/7)	0.15	0.597
Parkinsonism	2.1 % (1/48)		25 % (12/36)	0.001	0.050	27 % (9/24)	0.010	0.113
LBD pathology	3.7 % (2/52)		35 % (19/35)	<0.001	0.019	42 % (16/22)	<0.001	0.009
TDP-43 pathology	67 % (37/18)		84 % (48/9)	0.030	0.810	93 % (38/3)	0.003	0.097

For statistical tests, CTE with DPs compared to CTE without DPs (labeled CTE in table) and CTE with NPs compared to CTE without NPs (data not shown)

DP diffuse plaques, NP neuritic plaques

^*Student’s t test,

^**Pearson χ² test,

^{^}logistic regression controlling for age, significant p values are in bold