On D16, IB-MECA (0.1 mg/kg/d; D0–15; dark gray bars) attenuated paclitaxel-induced (P, black bars) elevations in TNF-α and IL-1β expression (A) and increased the levels of the anti-inflammatory cytokine, IL-10 (B) as compared to vehicle (V, open bars). The A3AR antagonist MRS1523 blocked IB-MECA’s effects (dark gray hatched bars) but had no effect on vehicle-treated (light gray bars) animals (A,B). Results are expressed as mean ± SD for n=6 and analyzed by one-way ANOVA with Dunnett’s post hoc comparisons. *P<0.05 vs. Vehicle; †P<0.05 vs. Paclitaxel