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. Author manuscript; available in PMC: 2015 Dec 1.
Published in final edited form as: Pain. 2014 Sep 19;155(12):2560–2567. doi: 10.1016/j.pain.2014.09.016

Fig. 3. IB-MECA decreases paclitaxel-induced spinal formation of pro-inflammatory TNF-α and IL-1β and increases the anti-inflammatory IL-10.

Fig. 3

On D16, IB-MECA (0.1 mg/kg/d; D0–15; dark gray bars) attenuated paclitaxel-induced (P, black bars) elevations in TNF-α and IL-1β expression (A) and increased the levels of the anti-inflammatory cytokine, IL-10 (B) as compared to vehicle (V, open bars). The A3AR antagonist MRS1523 blocked IB-MECA’s effects (dark gray hatched bars) but had no effect on vehicle-treated (light gray bars) animals (A,B). Results are expressed as mean ± SD for n=6 and analyzed by one-way ANOVA with Dunnett’s post hoc comparisons. *P<0.05 vs. Vehicle; †P<0.05 vs. Paclitaxel