FIG. 1.

Curvilinear relationship between sensor mean absolute relative difference (MARD) and percentage sensor deviations exceeding 20% from reference blood glucose level as defined by in silico experiments based on real continuous glucose monitoring–use data. Superimposed are (1) the placement of Dexcom G4 Platinum (triangle) and the same sensor with software 505 (circle), (2) the frequency per patient-year of biochemical severe hypoglycemia (defined as reference blood glucose of ≤39 mg/dL) during point-of-care continuous glucose monitoring use as a direct replacement of self-monitoring of blood glucose for insulin dosing and with threshold alerts that are properly attended to 100% of the time, and (3) the thresholds for nonadjunct sensor use as determined in silico.