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. Author manuscript; available in PMC: 2016 Apr 1.
Published in final edited form as: Fertil Steril. 2015 Feb 20;103(4):962–973.e4. doi: 10.1016/j.fertnstert.2014.12.130

Table 2.

Transvaginal ultrasound results and Baseline Lab Measurements in female participants by treatment arm

Clomiphene Letrozole Gonadotropin All
Left ovary not visualized 4/300(1.3%) 4/298(1.3%) 2/301(0.7%) 10/899(1.1%)
Right ovary not visualized 3/300(1.0%) 1/298(0.3%) 3/301(1.0%) 7/899(0.8%)
Neither ovary visualized 2/300(0.7%) 0/298(0.0%) 0/301(0.0%) 2/899(0.2%)
Morphology
  Left: Normal 160/295(54.2%) 147/294(50.0%) 174/299(58.2%) 481/888(54.2%)
    >12 follicles < 10 mm 116/295(39.3%) 133/294(45.2%) 104/299(34.8%) 353/888(39.8%)
    Hyperthecotic 19/295(6.4%) 14/294(4.8%) 21/299(7.0%) 54/888(6.1%)
  Right: Normal 142/297(47.8%) 150/297(50.5%) 154/298(51.7%) 446/892(50.0%)
    >12 follicles < 10 mm 135/297(45.5%) 133/297(44.8%) 115/298(38.6%) 383/892(42.9%)
    Hyperthecotic 20/297(6.7%) 14/297(4.7%) 29/298(9.7%) 63/892(7.1%)
  Both ovaries: Neither ovary
    >12 follicles less than 12 mm 104/294(35.4%) 106/293(36.2%) 118/296(39.9%) 328/883(37.1%)
    >12 follicles less than 12 mm /normal
combination		 93/294(31.6%) 84/293(28.7%) 90/296(30.4%) 267/883(30.2%)
      >12 follicles less than 10 mm
bilaterally		 97/294(33.0%) 103/293(35.2%) 88/296(29.7%) 288/883(32.6%)
Left ovarian volume(cm3)
  N 294 294 297 885
  Mean(SD) 8.7(11.0) 8.8(7.8) 7.6(5.0) 8.4(8.3)
Right ovarian volume(cm3)
  N 295 297 295 887
  Mean(SD) 9.4(6.7) 9.7(8.4) 9.1(7.1) 9.4(7.4)
Patients with at least one follicle/cyst>10 mm
diameter		 126/296(42.6%) 119/296(40.2%) 122/300(40.7%) 367/892(41.1%)
Size of largest follicle/cyst (cm3)
  N 118 112 109 339
  Mean(SD) 6.6(16.0) 4.0(7.3) 3.7(9.5) 4.8(11.7)
Antral follicle count: right ovary
  <5 42/293(14.3%) 38/294(12.9%) 37/294(12.6%) 117/881(13.3%)
  5–10 131/293(44.7%) 136/294(46.3%) 143/294(48.6%) 410/881(46.5%)
  10–15 71/293(24.2%) 68/294(23.1%) 61/294(20.7%) 200/881(22.7%)
  >15 49/293(16.7%) 52/294(17.7%) 53/294(18.0%) 154/881(17.5%)
Antral follicle count: left ovary
  <5 38/292(13.0%) 37/291(12.7%) 53/294(18.0%) 128/877(14.6%)
  5–10 142/292(48.6%) 132/291(45.4%) 140/294(47.6%) 414/877(47.2%)
  10–15 67/292(22.9%) 68/291(23.4%) 54/294(18.4%) 189/877(21.6%)
  >15 45/292(15.4%) 54/291(18.6%) 47/294(16.0%) 146/877(16.6%)
Antral follicle count: both ovaries
  N 291 289 290 870
  Mean(SD) 20.3(11.3) 21.2(11.2) 20.6(12.6) 20.7(11.7)
  <5 4/291(1.4%) 5/289(1.7%) 2/290(0.7%) 11/870(1.3%)
  5–10 43/291(14.8%) 39/289(13.5%) 50/290(17.2%) 132/870(15.2%)
  10–15
  >15 60/291(20.6%) 55/289(19.0%) 66/290(22.8%) 181/870(20.8%)
Reproductive Hormones 184/291(63.2%) 190/289(65.7%) 172/290 (59.3%) 546/870 (62.8%)
Total Testosterone (ng/dL)
  N 293 287 293 873
  Mean(SD) 24.7(16.6) 24.9(15.5) 26.4(29.7) 25.3(21.6)
  <=50 284/293(96.9%) 274/287(95.5%) 281/293(95.9%) 839/873(96.1%)
  50–100 8/293(2.7%) 10/287(3.5%) 11/293(3.8%) 29/873(3.3%)
  100–150 0/293(0.0%) 3/287(1.0%) 0/293(0.0%) 3/873(0.3%)
  >150 1/293(0.3%) 0/287(0.0%) 1/293(0.3%) 2/873(0.2%)
Calculated Free Androgen Index
  N 292 285 292 869
  Mean(SD) 2.4(9.1) 1.9(2.0) 2.0(2.2) 2.1(5.5)
  <=5 280/292(95.9%) 269/285(94.4%) 276/292(94.5%) 825/869(94.9%)
  5–10 9/292(3.1%) 13/285(4.6%) 13/292(4.5%) 35/869(4.0%)
  10–20 1/292(0.3%) 3/285(1.1%) 2/292(0.7%) 6/869(0.7%)
  >20 2/292(0.7%) 0/285(0.0%) 1/292(0.3%) 3/869(0.3%)
SHBG (nmol/L)
  N 294 285 292 871
  Mean(SD) 59.3(29.0) 60.0(28.2) 58.4(27.0) 59.2(28.1)
  <=25 24/294(8.2%) 22/285(7.7%) 21/292(7.2%) 67/871(7.7%)
  25–50 99/294(33.7%) 95/285(33.3%) 112/292(38.4%) 306/871(35.1%)
  50–75 101/294(34.4%) 92/285(32.3%) 83/292(28.4%) 276/871(31.7%)
  >75 70/294(23.8%) 76/285(26.7%) 76/292(26.0%) 222/871(25.5%)
DHEAS (ug/dL)
  N 294 287 293 874
  Mean(SD) 128.4(65.2) 131.4(68.9) 134.2(63.4) 131.3(65.8)
Androstenedione (ng/mL)
  N 292 284 289 865
  Mean(SD) 2.4(1.0) 2.4(1.0) 2.4(1.0) 2.4(1.0)
Estradiol (pg/mL)
  N 295 287 293 875
  Mean(SD) 32.4(21.5) 32.7(28.0) 33.7(40.4) 32.9(30.9)
Progesterone (ng/mL)
  N 294 286 293 873
  Mean(SD) 0.8(0.3) 0.8(0.5) 0.8(0.8) 0.8(0.6)
FSH(mIU/mL)
  N 295 287 293 875
  Mean(SD) 7.2(2.8) 7.0(2.9) 6.9(2.4) 7.0(2.7)
LH (mIU/mL)
  N 295 284 292 871
  Mean(SD) 5.0(2.5) 5.4(3.4) 4.9(2.5) 5.1(2.9)
TSH(uIU/mL)
  N 295 285 292 872
  Mean(SD) 2.0(1.0) 1.8(1.0)* 2.0(1.1) 1.9(1.0)
AMH (ng/mL)
  N 295 287 292 874
  Mean(SD) 2.6(2.1) 2.6(1.9) 2.6(2.1) 2.6(2.1)
Metabolic Hormones
Fasting glucose (mg/dL)
  N 295 287 293 875
  Mean(SD) 85.9(11.6) 85.4(11.9) 84.2(12.2) 85.2(11.9)
  <=100 273/295(92.5%) 267/287(93.0%) 275/293(93.9%) 815/875(93.1%)
  100–125 20/295(6.8%) 19/287(6.6%) 18/293(6.1%) 57/875(6.5%)
  >125 2/295(0.7%) 1/287(0.3%) 0/293(0.0%) 3/875(0.3%)
Fasting insulin (uIU/mL)
  N 295 286 293 874
  Mean(SD) 11.1(18.6) 9.4(15.5) 8.7(11.3) 9.7(15.5)
  <=10 209/295(70.8%) 217/286(75.9%) 213/293(72.7%) 639/874(73.1%)
  10–20 54/295(18.3%) 43/286(15.0%) 56/293(19.1%) 153/874(17.5%)
  20–50 23/295(7.8%) 20/286(7.0%) 18/293(6.1%) 61/874(7.0%)
  >50 9/295(3.1%) 6/286(2.1%) 6/293(2.0%) 21/874(2.4%)
HOMA-IR
  N 295 286 293 874
  Mean(SD) 2.57(4.3) 2.0(3.7) 1.9(2.7) 2.1(3.6)
Proinsulin (pmol/L)
  N 293 282 293 868
  Mean(SD) 13.7(8.7) 12.9(9.4) 12.1(7.1) 12.9(8.6)
hsCRP (mg/L)
  N 295 284 293 872
  Mean(SD) 3.4(5.5) 3.4(5.1) 3.2(4.1) 3.3(4.9)
Total cholesterol(mg/dL)
  N 284 277 283 844
  Mean(SD) 170.3(29.0) 169.0(33.0) 168.3(32.5) 169.2(31.5)
Triglycerides(mg/dL)
  N 284 277 283 844
  Mean(SD) 96.6(54.3) 92.0(45.6) 95.7(56.7) 94.8(52.4)
HDL cholesterol(mg/dL)
  N 284 277 283 844
  Mean(SD) 46.3(11.4) 45.5(11.0) 45.9(11.0) 45.9(11.1)
LDL cholesterol(mg/dL)
  N 284 277 283 844
  Mean(SD) 109.9(35.3) 108.3(27.6) 108.9(36.6) 109.0(33.4)
  >15 184/291(63.2%) 190/289(65.7%) 172/290(59.3%) 546/870(62.8%)
*

P-value between 0.05 and 0.1.