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. 2015 Aug 7;10(8):e0133937. doi: 10.1371/journal.pone.0133937

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© 2015 Hopper et al

This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are properly credited.

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Fig 4 — (A) Representative images of an average sample of each treatment group showing the macroscopic surface repair in femoral condyles. (B) Osteochondral healing of each treatment group stained with Safranin O/Fast Green. The scale bar represents the radius of the initial defect (6.0 mm). Some of the findings include: neocartilage formation on the surface of the defect (red/black vertical arrow) and remnants of the biomaterial (black horizontal arrow). (C) Safranin O/Fast Green stained high magnification (20x) images of the articular cartilage healing in the surface and in the subchondral bone where remnants of the biomaterial can be found. (D) Collagen type II staining and (E) Collagen type I staining at the repair site and within the remnants of the collagen biomaterial.