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. 2015 Aug 7;10(8):e0135397. doi: 10.1371/journal.pone.0135397

Fig 1. Putative biosynthetic pathway of CAM [11–20].

Fig 1

The terpenoid precursor secologanin was biosynthesized from MVA and / or MEP pathway through more than five steps of enzymatic oxidation. The amine precursor tryptamine was originated from shikimate pathway to tryptophan and followed by decarboxylation reaction. More than five cytochrome P450 enzymes were predicted to be involved in the conversion from strictosidine to CAM. The possible cytochrome P450 enzymes were highlighted in bold and its reduction partner CPR was in red. The other enzymes involved in the biosynthesis of CAM were omitted for clarity.