Table 4. Joint effects of TG-related risk alleles on TG level and the risk for a high TG level (≥ 150 mg/dl) in T2D patients.
| Quartile | TG, mg/dl | TG ≥ 150 mg/dl | |
|---|---|---|---|
| OR (95% CI) c | OR (95% CI) d | ||
| Q1 | 129.27 (92.09, 186.83) | 1 | 1 |
| Q2 | 142.56 (99.17, 204.54) | 1.27 (1.08,1.49) | 1.30 (1.10,1.54) |
| P = 4.34×10 −3 | P = 1.89×10 −3 | ||
| Q3 | 149.64 (107.14, 221.36) | 1.49 (1.27,1.75) | 1.51 (1.28,1.78) |
| P = 1.36×10 −6 | P = 1.08×10 −6 | ||
| Q4 | 147.87 (103.60, 223.13) | 1.45 (1.22,1.73) | 1.49 (1.25,1.77) |
| P = 2.10×10 −5 | P = 1.03×10 −5 | ||
| P a = 1.39×10 −12 | P trend = 5.17×10 −8 | P trend = 3.48×10 −8 | |
| P b = 1.71×10 −13 | |||
Abbreviations: BMI, body mass index; CI, confidence interval; OR, odds ratio; Q, quartile; TG, triglycerides. All non-Gaussian distributed quantitative traits were natural logarithmically transformed to normalize distributions.
a, P value calculated for genotype risk score for TG level using linear regression adjusted for age and sex.
b, P value calculated for genotype risk score for TG level using linear regression adjusted for age, sex, and BMI.
c, OR and 95% CI are reported for genotype risk score quartiles for a high TG level (≥ 150 mg/dl) using logistic regression adjusted for age and sex.
d, OR and 95% CI are reported for genotype risk score quartiles for a high TG level (≥ 150 mg/dl) using logistic regression adjusted for age, sex, and BMI.
P values <0.05 are shown in bold.