Fig 6. ATP-adenosine released following stimulation of glia modulates inhibitory components of locomotor networks.
A: raw (top) and rectified/integrated (bottom) traces recorded from left (L) and right (R) L2 ventral roots showing the effect of the PAR1 agonist TFLLR (10 μM) applied to preparations in which inhibitory transmission was blocked by the GABAA-receptor antagonist pictrotoxin (10 μM) and the glycine-receptor antagonist strychnine (1 μM). B: locomotor-burst frequency in disinhibited preparations over 6 min during a control period, immediately following TFLLR application, and following a 20-min washout period (n = 13). Individual data points are shown in grey and means are represented by black lines.