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. 2015 Jul 31;9:3989–4104. doi: 10.2147/DDDT.S85426

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© 2015 He et al. This work is published by Dove Medical Press Limited, and licensed under Creative Commons Attribution – Non Commercial (unported, v3.0) License

The full terms of the License are available at http://creativecommons.org/licenses/by-nc/3.0/. Non-commercial uses of the work are permitted without any further permission from Dove Medical Press Limited, provided the work is properly attributed.

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UA suppressed leptin-induced translocation of the p47^phox from cytoplasm to cell membrane in HSC-T6 cells.

Notes: Cells were pretreated with UA (50 µM), DPI (20 µM), or AG490 (50 µM) for 30 minutes and then were stimulated by leptin (100 ng/mL) for another 30 minutes. The membrane bound and total level of p47^phox were examined by Western blotting assay. (A) Representative blots of membrane (M-) p47^phox and total (T-) p47^phox in HSC-T6 cells. (B) Bar graph showing the relative level of M-p47^phox in HSC-T6 cells. Data are expressed as mean ± SD from six independent experiments. β-Actin acts as an internal control. *P<0.05; **P<0.01.

Abbreviations: UA, ursolic acid; HSC, hepatic stellate cell; DPI, diphenyleneiodonium; SD, standard deviation.