Table 3.
Category | Term | Count | % | P-value | Genes | Fold enrichment | Benjamini | FDR |
---|---|---|---|---|---|---|---|---|
Annotation cluster 1 | Enrichment score: 31.55 | |||||||
UP_SEQ_FEATURE | ATP binding site | 85 | 18.20 | 1.71E-43 | SPG7, TTK, AURKA, BTK, CSNK2A2, AKT1, PDPK1, CSNK2A1, MAT1A, MAP3K9, PAK4, PRKACA, PAK1, INSR, AKT2, SYK, PRKCA, EGFR, RET, SGK1, LYN, BRAF, ROCK1, PIM1, PRKCI, CDK6, ALK, CDK5, WEE1, CDK2, PRKCB, TYK2, MAPK1, PRKCQ, NME2, NME1, MAPK3, LCK, MAPK9, MAPK8, FGFR2, CHKA, FGFR1, ERBB4, NEK2, CHKB, ERBB2, MAPKAPK3, ADRBK1, CHEK1, MAPKAPK2, KIT, CHEK2, EPHB4, SRC, IRAK4, IGF1R, PTK2, PTK2B, TEK, ZAP70, CSF1R, PDK1, ITK, MAP2K1, HCK, PDK3, TGFBR1, PDK4, MET, RAF1, MAPK10, KDR, KHK, RPS6KA1, PLK1, FYN, MAPK14, GSK3B, DYRK1A, GRK6, JAK1, JAK3, TNK2, MERTK, ABL1 | 6.42 | 9.33E-41 | 2.87E-40 |
SP_PIR_KEYWORDS | Kinase | 89 | 19.06 | 5.29E-39 | TTK, AURKA, BTK, CSNK2A2, AKT1, PDPK1, CSNK2A1, MAP3K9, PAK4, PRKACA, PAK1, INSR, AKT2, SYK, PIK3CG, PRKCA, EGFR, RET, SGK1, LYN, BRAF, ROCK1, PIM1, PRKCI, CDK6, ALK, CDK5, WEE1, CDK2, PRKCB, TYK2, MAPK1, PRKCQ, PNKP, NME2, NME1, ADK, MAPK3, LCK, MAPK9, MAPK8, FGFR2, FGFR1, CHKA, CDK5R1, ERBB4, NEK2, CHKB, ERBB2, DCK, MAPKAPK3, ADRBK1, CHEK1, MAPKAPK2, KIT, CHEK2, EPHB4, SRC, IRAK4, IGF1R, PTK2, PTK2B, TEK, ZAP70, CSF1R, PDK1, ITK, MAP2K1, HCK, PDK3, TGFBR1, PDK4, MET, RAF1, MAPK10, KDR, KHK, RPS6KA1, PLK1, FYN, MAPK14, GSK3B, DYRK1A, GRK6, JAK1, JAK3, TNK2, MERTK, ABL1, PLAU | 5.33 | 1.40E-36 | 7.68E-36 |
INTERPRO | Protein kinase, ATP binding site | 77 | 16.49 | 1.08E-37 | TTK, AURKA, BTK, CSNK2A2, AKT1, PDPK1, CSNK2A1, MAP3K9, PAK4, PRKACA, PAK1, INSR, AKT2, SYK, PRKCA, EGFR, SGK1, RET, LYN, BRAF, ROCK1, PIM1, PRKCI, CDK6, ALK, CDK5, WEE1, CDK2, PRKCB, TYK2, MAPK1, PRKCQ, MAPK3, LCK, MAPK9, MAPK8, FGFR2, FGFR1, ERBB4, NEK2, ERBB2, MAPKAPK3, ADRBK1, CHEK1, MAPKAPK2, KIT, CHEK2, EPHB4, SRC, IRAK4, IGF1R, PTK2, PTK2B, TEK, ZAP70, CSF1R, ITK, MAP2K1, HCK, TGFBR1, MET, RAF1, MAPK10, KDR, RPS6KA1, FYN, PLK1, MAPK14, GSK3B, DYRK1A, GRK6, JAK1, ABCC1, JAK3, TNK2, MERTK, ABL1 | 6.05 | 9.68E-35 | 1.68E-34 |
UP_SEQ_FEATURE | Protein kinase | 72 | 15.42 | 5.38E-36 | TTK, AURKA, BTK, CSNK2A2, AKT1, PDPK1, CSNK2A1, MAP3K9, PAK4, PRKACA, PAK1, INSR, AKT2, SYK, PRKCA, EGFR, SGK1, RET, LYN, BRAF, ROCK1, PIM1, PRKCI, CDK6, ALK, CDK5, WEE1, CDK2, PRKCB, MAPK1, PRKCQ, MAPK3, LCK, MAPK9, MAPK8, FGFR2, FGFR1, ERBB4, NEK2, ERBB2, MAPKAPK3, ADRBK1, CHEK1, MAPKAPK2, KIT, CHEK2, EPHB4, SRC, IRAK4, IGF1R, PTK2, PTK2B, TEK, ZAP70, CSF1R, ITK, MAP2K1, TGFBR1, HCK, MET, RAF1, MAPK10, KDR, FYN, PLK1, MAPK14, GSK3B, DYRK1A, GRK6, TNK2, MERTK, ABL1 | 6.28 | 2.20E-33 | 9.04E-33 |
INTERPRO | Protein kinase | 76 | 16.27 | 2.09E-35 | TTK, AURKA, BTK, CSNK2A2, AKT1, PDPK1, CSNK2A1, MAP3K9, PAK4, PRKACA, PAK1, INSR, AKT2, SYK, PRKCA, EGFR, SGK1, RET, LYN, BRAF, ROCK1, PIM1, PRKCI, CDK6, ALK, CDK5, WEE1, CDK2, PRKCB, TYK2, MAPK1, PRKCQ, MAPK3, LCK, MAPK9, MAPK8, FGFR2, FGFR1, ERBB4, NEK2, ERBB2, MAPKAPK3, ADRBK1, CHEK1, MAPKAPK2, KIT, CHEK2, EPHB4, SRC, IRAK4, IGF1R, PTK2, PTK2B, TEK, ZAP70, CSF1R, ITK, MAP2K1, HCK, TGFBR1, MET, RAF1, MAPK10, KDR, RPS6KA1, FYN, PLK1, MAPK14, GSK3B, DYRK1A, GRK6, JAK1, JAK3, TNK2, MERTK, ABL1 | 5.71 | 9.38E-33 | 3.26E-32 |
UP_SEQ_FEATURE | Nucleotide phosphate-binding region | 96 | 20.56 | 1.27E-32 | SPG7, TTK, AURKA, BTK, CSNK2A2, AKT1, PDPK1, CSNK2A1, MAT1A, MAP3K9, PAK4, ABCB10, PRKACA, PAK1, INSR, AKT2, SYK, PRKCA, EGFR, RET, SGK1, KIF11, LYN, BRAF, ROCK1, PIM1, PRKCI, CDK6, ALK, CDK5, WEE1, CDK2, PRKCB, TYK2, MAPK1, PNKP, PRKCQ, LCK, MAPK3, MAPK9, MAPK8, FGFR2, FGFR1, CHKA, ERBB4, NEK2, CHKB, ERBB2, MAPKAPK3, DCK, ADRBK1, CHEK1, MAPKAPK2, KIT, CHEK2, EPHB4, SRC, IRAK4, IGF1R, PTK2, PTK2B, TEK, TAP1, ZAP70, CSF1R, PDK1, ITK, DHX9, MAP2K1, HCK, PDK3, TGFBR1, PDK4, MET, RAF1, ACACB, MAPK10, ABCB6, KDR, GART, KHK, RPS6KA1, VCP, PLK1, FYN, MAPK14, GSK3B, DYRK1A, UBA3, GRK6, JAK1, TNK2, JAK3, MERTK, ABL1, CLCN5 | 4.08 | 4.17E-30 | 2.14E-29 |
GOTERM_BP_FAT | Protein amino acid phosphorylation | 88 | 18.84 | 1.18E-29 | TTK, AURKA, BTK, CSNK2A2, AKT1, PDPK1, APP, CSNK2A1, CXCR4, MAP3K9, PAK4, PRKACA, PAK1, BRD4, INSR, AKT2, SYK, PIK3CG, PRKCA, EGFR, RET, SGK1, LYN, BRAF, ROCK1, PIM1, PRKCI, CDK6, ALK, CDK5, WEE1, CDK2, PRKCB, TYK2, MAPK1, PRKCQ, LCK, F2, MAPK3, MAPK9, MAPK8, FGFR2, FGFR1, CDK5R1, ERBB4, NEK2, ERBB2, MAPKAPK3, ADRBK1, CHEK1, MAPKAPK2, KIT, CHEK2, EPHB4, SRC, IRAK4, IGF1R, PTK2, PTK2B, BCL2, TEK, ZAP70, CSF1R, PDK1, ITK, MAP2K1, HCK, PDK3, TGFBR1, PDK4, MET, BIRC7, RAF1, MAPK10, KDR, PTPN11, RPS6KA1, PLK1, FYN, MAPK14, GSK3B, DYRK1A, GRK6, JAK1, JAK3, TNK2, MERTK, ABL1 | 4.00 | 3.79E-26 | 2.13E-26 |
GOTERM_MF_FAT | Protein kinase activity | 82 | 17.56 | 7.32E-27 | NRP1, TTK, AURKA, BTK, CSNK2A2, AKT1, PDPK1, CSNK2A1, MAP3K9, PAK4, PRKACA, PAK1, INSR, AKT2, SYK, PRKCA, EGFR, RET, SGK1, LYN, BRAF, ROCK1, PIM1, PRKCI, CDK6, ALK, CDK5, WEE1, CDK2, PRKCB, TYK2, MAPK1, PRKCQ, MAPK3, LCK, MAPK9, MAPK8, FGFR2, FGFR1, CDK5R1, ERBB4, NEK2, ERBB2, MAPKAPK3, FKBP1A, ADRBK1, CHEK1, MAPKAPK2, KIT, CHEK2, EPHB4, SRC, IRAK4, IGF1R, PTK2, PTK2B, TEK, ZAP70, CSF1R, PDK1, ITK, MAP2K1, HCK, PDK3, TGFBR1, PDK4, MET, RAF1, MAPK10, KDR, RPS6KA1, FYN, PLK1, MAPK14, GSK3B, DYRK1A, GRK6, JAK1, JAK3, TNK2, MERTK, ABL1 | 3.90 | 6.19E-24 | 1.13E-23 |
GOTERM_BP_FAT | Phosphorylation | 90 | 19.27 | 2.98E-25 | TTK, AURKA, BTK, CSNK2A2, AKT1, PDPK1, APP, CSNK2A1, CXCR4, MAP3K9, PAK4, PRKACA, PAK1, BRD4, INSR, AKT2, SYK, PIK3CG, PRKCA, EGFR, RET, SGK1, LYN, BRAF, ROCK1, PIM1, PRKCI, CDK6, ALK, CDK5, WEE1, CDK2, PRKCB, TYK2, MAPK1, PRKCQ, PNKP, NME2, NME1, LCK, F2, MAPK3, MAPK9, MAPK8, FGFR2, FGFR1, CDK5R1, ERBB4, NEK2, ERBB2, MAPKAPK3, ADRBK1, CHEK1, MAPKAPK2, KIT, CHEK2, EPHB4, SRC, IRAK4, IGF1R, PTK2, PTK2B, BCL2, TEK, ZAP70, CSF1R, PDK1, ITK, MAP2K1, HCK, PDK3, TGFBR1, PDK4, MET, BIRC7, RAF1, MAPK10, KDR, PTPN11, RPS6KA1, PLK1, FYN, MAPK14, GSK3B, DYRK1A, GRK6, JAK1, TNK2, JAK3, MERTK, ABL1 | 3.41 | 3.20E-22 | 5.41E-22 |
GOTERM_BP_FAT | Phosphate metabolic process | 99 | 21.20 | 1.53E-24 | TTK, AURKA, BTK, CSNK2A2, APP, CSNK2A1, MAP3K9, PRKACA, INSR, SYK, PIK3CG, EGFR, RET, BRAF, ROCK1, PIM1, PPP1CC, WEE1, MAPK1, PNKP, PPP1CA, NME2, NME1, F2, MAPK3, MAPK9, MAPK8, FGFR2, FGFR1, CDK5R1, ERBB4, NEK2, ERBB2, MAPKAPK3, CHEK1, ADRBK1, MAPKAPK2, CHEK2, EPHB4, SRC, IRAK4, PTK2, TEK, ZAP70, CSF1R, ITK, MAP2K1, TGFBR1, MET, KDR, PTPN11, PLK1, DYRK1A, GRK6, TNK2, PTPN1, MERTK, ABL1, PTEN, AKT1, PDPK1, CXCR4, PAK4, PAK1, BRD4, AKT2, PRKCA, PPP2R1A, SGK1, LYN, PRKCI, CDK6, ALK, CDK5, CDK2, PRKCB, TYK2, PRKCQ, LCK, KIT, IGF1R, DAPP1, PTK2B, BCL2, PPP2CA, PTPRB, PDK1, HCK, PDK3, PDK4, BIRC7, RAF1, MAPK10, DUSP3, RPS6KA1, FYN, MAPK14, GSK3B, JAK1, JAK3 | 3.09 | 1.23E-21 | 2.78E-21 |
GOTERM_BP_FAT | Phosphorus metabolic process | 99 | 21.20 | 1.53E-24 | TTK, AURKA, BTK, CSNK2A2, APP, CSNK2A1, MAP3K9, PRKACA, INSR, SYK, PIK3CG, EGFR, RET, BRAF, ROCK1, PIM1, PPP1CC, WEE1, MAPK1, PNKP, PPP1CA, NME2, NME1, F2, MAPK3, MAPK9, MAPK8, FGFR2, FGFR1, CDK5R1, ERBB4, NEK2, ERBB2, MAPKAPK3, CHEK1, ADRBK1, MAPKAPK2, CHEK2, EPHB4, SRC, IRAK4, PTK2, TEK, ZAP70, CSF1R, ITK, MAP2K1, TGFBR1, MET, KDR, PTPN11, PLK1, DYRK1A, GRK6, TNK2, PTPN1, MERTK, ABL1, PTEN, AKT1, PDPK1, CXCR4, PAK4, PAK1, BRD4, AKT2, PRKCA, PPP2R1A, SGK1, LYN, PRKCI, CDK6, ALK, CDK5, CDK2, PRKCB, TYK2, PRKCQ, LCK, KIT, IGF1R, DAPP1, PTK2B, BCL2, PPP2CA, PTPRB, PDK1, HCK, PDK3, PDK4, BIRC7, RAF1, MAPK10, DUSP3, RPS6KA1, FYN, MAPK14, GSK3B, JAK1, JAK3 | 3.09 | 1.23E-21 | 2.78E-21 |
Annotation cluster 2 | Enrichment score: 23.53 | |||||||
SP_PIR_KEYWORDS | Tyrosine protein kinase | 36 | 7.71 | 1.26E-29 | FGFR2, FGFR1, ERBB4, ERBB2, TTK, KIT, EPHB4, SRC, BTK, IGF1R, PTK2, PTK2B, TEK, ZAP70, INSR, SYK, CSF1R, EGFR, ITK, RET, MAP2K1, LYN, HCK, MET, ALK, WEE1, KDR, TYK2, FYN, DYRK1A, LCK, JAK1, JAK3, TNK2, MERTK, ABL1 | 13.36 | 1.33E-27 | 1.83E-26 |
INTERPRO | Tyrosine protein kinase, active site | 32 | 6.85 | 9.13E-25 | FGFR2, FGFR1, ERBB4, ERBB2, KIT, EPHB4, SRC, BTK, IGF1R, PTK2, PTK2B, TEK, ZAP70, INSR, SYK, CSF1R, EGFR, ITK, RET, LYN, HCK, MET, ALK, KDR, TYK2, FYN, LCK, JAK1, JAK3, TNK2, MERTK, ABL1 | 11.79 | 2.73E-22 | 1.42E-21 |
INTERPRO | Tyrosine protein kinase | 34 | 7.28 | 3.37E-24 | FGFR2, FGFR1, ERBB4, ERBB2, KIT, EPHB4, SRC, BTK, IRAK4, IGF1R, PTK2, PTK2B, MAP3K9, TEK, ZAP70, INSR, SYK, CSF1R, EGFR, ITK, RET, LYN, HCK, MET, ALK, KDR, TYK2, FYN, LCK, JAK1, JAK3, TNK2, MERTK, ABL1 | 10.30 | 7.57E-22 | 5.26E-21 |
SMART | TyrKc | 34 | 7.28 | 1.43E-22 | FGFR2, FGFR1, ERBB4, ERBB2, KIT, EPHB4, SRC, BTK, IRAK4, IGF1R, PTK2, PTK2B, MAP3K9, TEK, ZAP70, INSR, SYK, CSF1R, EGFR, ITK, RET, LYN, HCK, MET, ALK, KDR, TYK2, FYN, LCK, JAK1, JAK3, TNK2, MERTK, ABL1 | 8.93 | 2.41E-20 | 1.74E-19 |
GOTERM_MF_FAT | Protein tyrosine kinase activity | 38 | 8.14 | 3.94E-20 | FGFR2, FGFR1, NRP1, ERBB4, ERBB2, TTK, KIT, EPHB4, SRC, BTK, IRAK4, IGF1R, PTK2, PTK2B, TEK, ZAP70, INSR, SYK, CSF1R, EGFR, ITK, RET, MAP2K1, LYN, HCK, MET, ALK, WEE1, KDR, TYK2, FYN, DYRK1A, LCK, JAK1, JAK3, TNK2, MERTK, ABL1 | 6.60 | 1.67E-17 | 6.10E-17 |
Annotation cluster 3 | Enrichment score: 16.58 | |||||||
UP_SEQ_FEATURE | Nucleotide phosphate- binding region: ATP | 96 | 20.56 | 1.27E-32 | SPG7, TTK, AURKA, BTK, CSNK2A2, AKT1, PDPK1, CSNK2A1, MAT1A, MAP3K9, PAK4, ABCB10, PRKACA, PAK1, INSR, AKT2, SYK, PRKCA, EGFR, RET, SGK1, KIF11, LYN, BRAF, ROCK1, PIM1, PRKCI, CDK6, ALK, CDK5, WEE1, CDK2, PRKCB, TYK2, MAPK1, PNKP, PRKCQ, LCK, MAPK3, MAPK9, MAPK8, FGFR2, FGFR1, CHKA, ERBB4, NEK2, CHKB, ERBB2, MAPKAPK3, DCK, ADRBK1, CHEK1, MAPKAPK2, KIT, CHEK2, EPHB4, SRC, IRAK4, IGF1R, PTK2, PTK2B, TEK, TAP1, ZAP70, CSF1R, PDK1, ITK, DHX9, MAP2K1, HCK, PDK3, TGFBR1, PDK4, MET, RAF1, ACACB, MAPK10, ABCB6, KDR, GART, KHK, RPS6KA1, VCP, PLK1, FYN, MAPK14, GSK3B, DYRK1A, UBA3, GRK6, JAK1, TNK2, JAK3, MERTK, ABL1, CLCN5 | 4.08 | 4.17E-30 | 2.14E-29 |
SP_PIR_KEYWORDS | ATP binding | 107 | 22.91 | 7.66E-29 | IDE, TTK, AURKA, BTK, CSNK2A2, CSNK2A1, MAT1A, MAP3K9, ABCB10, PRKACA, INSR, SYK, PIK3CG, EGFR, RET, BRAF, ROCK1, PIM1, WEE1, MAPK1, PNKP, NME2, NME1, MAPK3, MAPK9, MAPK8, FGFR2, FGFR1, CHKA, ERBB4, NEK2, CHKB, ERBB2, FARS2, MAPKAPK3, CHEK1, ADRBK1, CHEK2, MAPKAPK2, EPHB4, SRC, IRAK4, PTK2, TEK, ZAP70, CSF1R, DHX9, ITK, MAP2K1, TGFBR1, MET, ACACB, ABCB6, KDR, GART, ATP7A, VCP, PLK1, UBA3, DYRK1A, GRK6, TNK2, MERTK, ABL1, CLCN5, UBE2E1, HSP90AB1, SPG7, AKT1, PDPK1, PAK4, PAK1, AKT2, PRKCA, SGK1, HSP90AA1, KIF11, LYN, PRKCI, CDK6, CFTR, ALK, CDK5, CDK2, PRKCB, TYK2, PRKCQ, ADK, LCK, DCK, KIT, IGF1R, PTK2B, TAP1, PDK1, HCK, PDK3, PDK4, RAF1, MAPK10, KHK, RPS6KA1, FYN, MAPK14, GSK3B, JAK1, ABCC1, JAK3 | 3.32 | 6.74E-27 | 1.11E-25 |
SP_PIR_KEYWORDS | Nucleotide binding | 118 | 25.27 | 1.72E-26 | HRAS, IDE, TTK, AURKA, BTK, CSNK2A2, CSNK2A1, MAT1A, MAP3K9, ABCB10, PRKACA, INSR, SYK, PIK3CG, EGFR, NUDT2, RET, BRAF, ROCK1, PIM1, WEE1, PNKP, MAPK1, NME2, NME1, PDE5A, MAPK3, MAPK9, MAPK8, FGFR2, FGFR1, CHKA, ERBB4, GNAI1, NEK2, CHKB, ERBB2, FARS2, MAPKAPK3, CHEK1, ADRBK1, CHEK2, MAPKAPK2, EPHB4, SRC, IRAK4, PTK2, TEK, RAC1, ZAP70, CSF1R, ITK, DHX9, MAP2K1, TGFBR1, MET, ACACB, ABCB6, KDR, GART, ATP7A, VCP, PLK1, UBA3, DYRK1A, GRK6, TNK2, MERTK, ABL1, CLCN5, UBE2E1, HSP90AB1, SPG7, AKT1, CDC42, PDPK1, NT5M, PAK4, PAK1, AKT2, PRKCA, SGK1, HSP90AA1, KIF11, LYN, PRKCI, CDK6, CFTR, ALK, CDK5, CDK2, PRKCB, TYK2, PRKCQ, ADK, LCK, DCK, KIT, IGF1R, PTK2B, TAP1, GIMAP2, PDK1, HCK, PDK3, PDK4, RAF1, MAPK10, PCK1, KHK, PDE2A, RPS6KA1, PYGL, FYN, MAPK14, GSK3B, JAK1, ABCC1, JAK3 | 2.88 | 1.14E-24 | 2.50E-23 |
GOTERM_MF_FAT | ATP binding | 110 | 23.56 | 4.31E-15 | IDE, TTK, AURKA, BTK, CSNK2A2, CSNK2A1, MAT1A, MAP3K9, ABCB10, PRKACA, INSR, SYK, PIK3CG, EGFR, RET, BRAF, ROCK1, PIM1, WEE1, PNKP, MAPK1, NME2, NME1, MAPK3, MAPK9, MAPK8, FGFR2, FGFR1, CHKA, ERBB4, NEK2, CHKB, ERBB2, FARS2, MAPKAPK3, CHEK1, ADRBK1, CHEK2, MAPKAPK2, EPHB4, SRC, IRAK4, PTK2, TEK, ZAP70, CSF1R, ITK, DHX9, MAP2K1, TGFBR1, MET, ACACB, ABCB6, KDR, GART, ATP7A, VCP, PLK1, UBA3, DYRK1A, GRK6, TNK2, MERTK, ABL1, CLCN5, UBE2E1, HSP90AB1, SPG7, AKT1, PDPK1, PAK4, PAK1, AKT2, PRKCA, SGK1, HSP90AA1, KIF11, LYN, TP53, PRKCI, CDK6, CFTR, ALK, CDK5, CDK2, PRKCB, TYK2, PRKCQ, ADK, LCK, DCK, KIT, IGF1R, PTK2B, TAP1, TGM2, PDK1, HCK, PDK3, PDK4, RAF1, MAPK10, KHK, RPS6KA1, FYN, PYGL, MAPK14, GSK3B, JAK1, ABCC1, JAK3 | 2.15 | 5.23E-13 | 6.69E-12 |
GOTERM_MF_FAT | Nucleoside binding | 116 | 24.84 | 6.62E-15 | IDE, TTK, AURKA, PNP, BTK, CSNK2A2, KDM1A, CSNK2A1, MAT1A, MAP3K9, ABCB10, PRKACA, INSR, SYK, PIK3CG, EGFR, RET, BRAF, ROCK1, PIM1, WEE1, PNKP, MAPK1, NME2, NME1, PDE5A, MAPK3, MAPK9, MAPK8, FGFR2, XDH, FGFR1, CHKA, ERBB4, NEK2, CHKB, ERBB2, FARS2, MAPKAPK3, CHEK1, ADRBK1, CHEK2, MAPKAPK2, EPHB4, SRC, IRAK4, PTK2, TEK, ZAP70, CDA, CSF1R, ITK, DHX9, MAP2K1, TGFBR1, MET, ACACB, ABCB6, KDR, GART, ATP7A, VCP, PLK1, UBA3, DYRK1A, GRK6, TNK2, MERTK, ABL1, CLCN5, UBE2E1, HSP90AB1, SPG7, AKT1, PDPK1, PAK4, PAK1, AKT2, PRKCA, SGK1, HSP90AA1, KIF11, LYN, TP53, PRKCI, CDK6, CFTR, ALK, CDK5, CDK2, PRKCB, TYK2, PRKCQ, ADK, LCK, DCK, KIT, IGF1R, PTK2B, TAP1, TGM2, PDK1, HCK, PDK3, PDK4, RAF1, MAPK10, PCK1, KHK, RPS6KA1, PYGL, FYN, MAPK14, GSK3B, JAK1, ABCC1, JAK3 | 2.08 | 6.26E-13 | 1.03E-11 |
GOTERM_MF_FAT | Adenyl ribonucleotide binding | 110 | 23.56 | 1.07E-14 | IDE, TTK, AURKA, BTK, CSNK2A2, CSNK2A1, MAT1A, MAP3K9, ABCB10, PRKACA, INSR, SYK, PIK3CG, EGFR, RET, BRAF, ROCK1, PIM1, WEE1, PNKP, MAPK1, NME2, NME1, MAPK3, MAPK9, MAPK8, FGFR2, FGFR1, CHKA, ERBB4, NEK2, CHKB, ERBB2, FARS2, MAPKAPK3, CHEK1, ADRBK1, CHEK2, MAPKAPK2, EPHB4, SRC, IRAK4, PTK2, TEK, ZAP70, CSF1R, ITK, DHX9, MAP2K1, TGFBR1, MET, ACACB, ABCB6, KDR, GART, ATP7A, VCP, PLK1, UBA3, DYRK1A, GRK6, TNK2, MERTK, ABL1, CLCN5, UBE2E1, HSP90AB1, SPG7, AKT1, PDPK1, PAK4, PAK1, AKT2, PRKCA, SGK1, HSP90AA1, KIF11, LYN, TP53, PRKCI, CDK6, CFTR, ALK, CDK5, CDK2, PRKCB, TYK2, PRKCQ, ADK, LCK, DCK, KIT, IGF1R, PTK2B, TAP1, TGM2, PDK1, HCK, PDK3, PDK4, RAF1, MAPK10, KHK, RPS6KA1, FYN, PYGL, MAPK14, GSK3B, JAK1, ABCC1, JAK3 | 2.12 | 9.11E-13 | 1.67E-11 |
GOTERM_MF_FAT | Purine nucleoside binding | 114 | 24.41 | 2.63E-14 | IDE, TTK, AURKA, BTK, CSNK2A2, KDM1A, CSNK2A1, MAT1A, MAP3K9, ABCB10, PRKACA, INSR, SYK, PIK3CG, EGFR, RET, BRAF, ROCK1, PIM1, WEE1, PNKP, MAPK1, NME2, NME1, PDE5A, MAPK3, MAPK9, MAPK8, FGFR2, XDH, FGFR1, CHKA, ERBB4, NEK2, CHKB, ERBB2, FARS2, MAPKAPK3, CHEK1, ADRBK1, CHEK2, MAPKAPK2, EPHB4, SRC, IRAK4, PTK2, TEK, ZAP70, CSF1R, ITK, DHX9, MAP2K1, TGFBR1, MET, ACACB, ABCB6, KDR, GART, ATP7A, VCP, PLK1, UBA3, DYRK1A, GRK6, TNK2, MERTK, ABL1, CLCN5, UBE2E1, HSP90AB1, SPG7, AKT1, PDPK1, PAK4, PAK1, AKT2, PRKCA, SGK1, HSP90AA1, KIF11, LYN, TP53, PRKCI, CDK6, CFTR, ALK, CDK5, CDK2, PRKCB, TYK2, PRKCQ, ADK, LCK, DCK, KIT, IGF1R, PTK2B, TAP1, TGM2, PDK1, HCK, PDK3, PDK4, RAF1, MAPK10, PCK1, KHK, RPS6KA1, PYGL, FYN, MAPK14, GSK3B, JAK1, ABCC1, JAK3 | 2.05 | 2.02E-12 | 4.07E-11 |
GOTERM_MF_FAT | Adenyl nucleotide binding | 112 | 23.98 | 5.87E-14 | IDE, TTK, AURKA, BTK, CSNK2A2, KDM1A, CSNK2A1, MAT1A, MAP3K9, ABCB10, PRKACA, INSR, SYK, PIK3CG, EGFR, RET, BRAF, ROCK1, PIM1, WEE1, PNKP, MAPK1, NME2, NME1, MAPK3, MAPK9, MAPK8, FGFR2, XDH, FGFR1, CHKA, ERBB4, NEK2, CHKB, ERBB2, FARS2, MAPKAPK3, CHEK1, ADRBK1, CHEK2, MAPKAPK2, EPHB4, SRC, IRAK4, PTK2, TEK, ZAP70, CSF1R, ITK, DHX9, MAP2K1, TGFBR1, MET, ACACB, ABCB6, KDR, GART, ATP7A, VCP, PLK1, UBA3, DYRK1A, GRK6, TNK2, MERTK, ABL1, CLCN5, UBE2E1, HSP90AB1, SPG7, AKT1, PDPK1, PAK4, PAK1, AKT2, PRKCA, SGK1, HSP90AA1, KIF11, LYN, TP53, PRKCI, CDK6, CFTR, ALK, CDK5, CDK2, PRKCB, TYK2, PRKCQ, ADK, LCK, DCK, KIT, IGF1R, PTK2B, TAP1, TGM2, PDK1, HCK, PDK3, PDK4, RAF1, MAPK10, KHK, RPS6KA1, FYN, PYGL, MAPK14, GSK3B, JAK1, ABCC1, JAK3 | 2.05 | 3.82E-12 | 9.08E-11 |
GOTERM_MF_FAT | Nucleotide binding | 137 | 29.34 | 4.05E-12 | NCBP2, HRAS, HMGCR, IDE, TTK, AURKA, BTK, CSNK2A2, KDM1A, CSNK2A1, MAT1A, MAP3K9, ABCB10, PRKACA, INSR, SYK, PIK3CG, EGFR, RET, NUDT2, ROCK1, BRAF, PIM1, PPARGC1A, WEE1, POR, PNKP, MAPK1, NME2, NME1, PDE5A, MAPK3, MAPK9, MAPK8, XDH, FGFR2, FGFR1, CHKA, HSD17B10, ME2, ERBB4, GNAI1, NEK2, FARS2, CHKB, ERBB2, MAPKAPK3, CHEK1, ADRBK1, CHEK2, MAPKAPK2, EPHB4, SRC, IRAK4, PTK2, TEK, RAC1, ZAP70, CSF1R, ITK, DHX9, MAP2K1, TGFBR1, MET, NXF1, ACACB, ABCB6, KDR, GART, ATP7A, DHFR, VCP, PLK1, UBA3, DYRK1A, GRK6, TNK2, MERTK, ABL1, PARP1, UBE2E1, CLCN5, HSP90AB1, SPG7, AKT1, CDC42, PDPK1, PARN, NT5M, PAK4, PAK1, AKT2, PRKCA, SGK1, HSP90AA1, KIF11, LYN, PRKCI, TP53, CFTR, CDK6, CBR3, ALK, CDK5, CDK2, PRKCB, TYK2, PRKCQ, G6PD, ADK, LCK, DCK, ADH5, KIT, TYMS, IGF1R, PTK2B, ADH4, TAP1, TGM2, GIMAP2, PDK1, HCK, PDK3, PDK4, SIRT5, RAF1, MAPK10, PCK1, KHK, RPS6KA1, PYGL, FYN, MAPK14, GSK3B, JAK1, ABCC1, JAK3 | 1.76 | 2.28E-10 | 6.26E-09 |
GOTERM_MF_FAT | Ribonucleotide binding | 118 | 25.27 | 9.49E-12 | HRAS, IDE, TTK, AURKA, BTK, CSNK2A2, CSNK2A1, MAT1A, MAP3K9, ABCB10, PRKACA, INSR, SYK, PIK3CG, EGFR, RET, NUDT2, BRAF, ROCK1, PIM1, WEE1, PNKP, MAPK1, NME2, NME1, PDE5A, MAPK3, MAPK9, MAPK8, FGFR2, FGFR1, CHKA, ERBB4, GNAI1, NEK2, CHKB, ERBB2, FARS2, MAPKAPK3, CHEK1, ADRBK1, CHEK2, MAPKAPK2, EPHB4, SRC, IRAK4, PTK2, TEK, RAC1, ZAP70, CSF1R, ITK, DHX9, MAP2K1, TGFBR1, MET, ACACB, ABCB6, KDR, GART, ATP7A, VCP, PLK1, UBA3, DYRK1A, GRK6, TNK2, MERTK, ABL1, CLCN5, UBE2E1, HSP90AB1, SPG7, AKT1, CDC42, PDPK1, PAK4, PAK1, AKT2, PRKCA, SGK1, HSP90AA1, KIF11, LYN, TP53, PRKCI, CDK6, CFTR, ALK, CDK5, CDK2, PRKCB, TYK2, PRKCQ, ADK, LCK, DCK, KIT, IGF1R, PTK2B, TAP1, TGM2, GIMAP2, PDK1, HCK, PDK3, PDK4, RAF1, MAPK10, PCK1, KHK, RPS6KA1, PYGL, FYN, MAPK14, GSK3B, JAK1, ABCC1, JAK3 | 1.85 | 4.72E-10 | 1.47E-08 |
GOTERM_MF_FAT | Purine ribonucleotide binding | 118 | 25.27 | 9.49E-12 | HRAS, IDE, TTK, AURKA, BTK, CSNK2A2, CSNK2A1, MAT1A, MAP3K9, ABCB10, PRKACA, INSR, SYK, PIK3CG, EGFR, RET, NUDT2, BRAF, ROCK1, PIM1, WEE1, PNKP, MAPK1, NME2, NME1, PDE5A, MAPK3, MAPK9, MAPK8, FGFR2, FGFR1, CHKA, ERBB4, GNAI1, NEK2, CHKB, ERBB2, FARS2, MAPKAPK3, CHEK1, ADRBK1, CHEK2, MAPKAPK2, EPHB4, SRC, IRAK4, PTK2, TEK, RAC1, ZAP70, CSF1R, ITK, DHX9, MAP2K1, TGFBR1, MET, ACACB, ABCB6, KDR, GART, ATP7A, VCP, PLK1, UBA3, DYRK1A, GRK6, TNK2, MERTK, ABL1, CLCN5, UBE2E1, HSP90AB1, SPG7, AKT1, CDC42, PDPK1, PAK4, PAK1, AKT2, PRKCA, SGK1, HSP90AA1, KIF11, LYN, TP53, PRKCI, CDK6, CFTR, ALK, CDK5, CDK2, PRKCB, TYK2, PRKCQ, ADK, LCK, DCK, KIT, IGF1R, PTK2B, TAP1, TGM2, GIMAP2, PDK1, HCK, PDK3, PDK4, RAF1, MAPK10, PCK1, KHK, RPS6KA1, PYGL, FYN, MAPK14, GSK3B, JAK1, ABCC1, JAK3 | 1.85 | 4.72E-10 | 1.47E-08 |
GOTERM_MF_FAT | Purine nucleotide binding | 120 | 25.70 | 3.44E-11 | HRAS, IDE, TTK, AURKA, BTK, CSNK2A2, KDM1A, CSNK2A1, MAT1A, MAP3K9, ABCB10, PRKACA, INSR, SYK, PIK3CG, EGFR, RET, NUDT2, BRAF, ROCK1, PIM1, WEE1, PNKP, MAPK1, NME2, NME1, PDE5A, MAPK3, MAPK9, MAPK8, FGFR2, XDH, FGFR1, CHKA, ERBB4, GNAI1, NEK2, CHKB, ERBB2, FARS2, MAPKAPK3, CHEK1, ADRBK1, CHEK2, MAPKAPK2, EPHB4, SRC, IRAK4, PTK2, TEK, RAC1, ZAP70, CSF1R, ITK, DHX9, MAP2K1, TGFBR1, MET, ACACB, ABCB6, KDR, GART, ATP7A, VCP, PLK1, UBA3, DYRK1A, GRK6, TNK2, MERTK, ABL1, CLCN5, UBE2E1, HSP90AB1, SPG7, AKT1, CDC42, PDPK1, PAK4, PAK1, AKT2, PRKCA, SGK1, HSP90AA1, KIF11, LYN, TP53, PRKCI, CDK6, CFTR, ALK, CDK5, CDK2, PRKCB, TYK2, PRKCQ, ADK, LCK, DCK, KIT, IGF1R, PTK2B, TAP1, TGM2, GIMAP2, PDK1, HCK, PDK3, PDK4, RAF1, MAPK10, PCK1, KHK, RPS6KA1, PYGL, FYN, MAPK14, GSK3B, JAK1, ABCC1, JAK3 | 1.81 | 1.45E-09 | 5.32E-08 |
Annotation cluster 4 | Enrichment score: 16.40 | |||||||
UP_SEQ_FEATURE | DNA-binding region: nuclear receptor | 20 | 4.28 | 2.07E-19 | PPARA, PPARD, AR, RARG, THRA, THRB, RXRA, PPARG, ESRRG, ESR1, NR3C1, ESR2, NR1H2, PGR, VDR, NR1I3, NR1I2, RARB, NR1H4, NR1H3 | 18.19 | 5.65E-17 | 3.48E-16 |
UP_SEQ_FEATURE | Zinc finger region: NR C4 type | 20 | 4.28 | 2.07E-19 | PPARA, PPARD, AR, RARG, THRA, THRB, RXRA, PPARG, ESRRG, ESR1, NR3C1, ESR2, NR1H2, PGR, VDR, NR1I3, NR1I2, RARB, NR1H4, NR1H3 | 18.19 | 5.65E-17 | 3.48E-16 |
INTERPRO | Zinc finger, nuclear hormone receptor type | 20 | 4.28 | 4.10E-18 | PPARA, PPARD, AR, RARG, THRA, THRB, RXRA, PPARG, ESRRG, ESR1, NR3C1, ESR2, NR1H2, PGR, VDR, NR1I3, NR1I2, RARB, NR1H4, NR1H3 | 15.54 | 7.36E-16 | 6.39E-15 |
INTERPRO | Nuclear hormone receptor, ligand binding, core | 20 | 4.28 | 1.08E-17 | PPARA, PPARD, AR, RARG, THRA, THRB, RXRA, PPARG, ESRRG, ESR1, NR3C1, ESR2, NR1H2, PGR, VDR, NR1I3, NR1I2, RARB, NR1H4, NR1H3 | 14.90 | 1.61E-15 | 1.68E-14 |
INTERPRO | Nuclear hormone receptor, ligand binding | 20 | 4.28 | 1.08E-17 | PPARA, PPARD, AR, RARG, THRA, THRB, RXRA, PPARG, ESRRG, ESR1, NR3C1, ESR2, NR1H2, PGR, VDR, NR1I3, NR1I2, RARB, NR1H4, NR1H3 | 14.90 | 1.61E-15 | 1.68E-14 |
SMART | ZnF_C4 | 20 | 4.28 | 4.44E-17 | PPARA, PPARD, AR, RARG, THRA, THRB, RXRA, PPARG, ESRRG, ESR1, NR3C1, ESR2, NR1H2, PGR, VDR, NR1I3, NR1I2, RARB, NR1H4, NR1H3 | 13.47 | 3.73E-15 | 5.40E-14 |
SMART | HOLI | 20 | 4.28 | 1.16E-16 | PPARA, PPARD, AR, RARG, THRA, THRB, RXRA, PPARG, ESRRG, ESR1, NR3C1, ESR2, NR1H2, PGR, VDR, NR1I3, NR1I2, RARB, NR1H4, NR1H3 | 12.91 | 6.22E-15 | 1.33E-13 |
INTERPRO | Steroid hormone receptor | 19 | 4.07 | 1.59E-16 | PPARA, PPARD, RARG, THRA, THRB, RXRA, PPARG, ESRRG, ESR1, NR3C1, ESR2, NR1H2, PGR, VDR, NR1I3, NR1I2, RARB, NR1H4, NR1H3 | 14.45 | 1.42E-14 | 1.78E-13 |
GOTERM_MF_FAT | Steroid hormone receptor activity | 20 | 4.28 | 8.16E-16 | PPARA, PPARD, AR, RARG, THRA, THRB, RXRA, PPARG, ESRRG, ESR1, NR3C1, ESR2, NR1H2, PGR, VDR, NR1I3, NR1I2, RARB, NR1H4, NR1H3 | 11.78 | 1.31E-13 | 1.20E-12 |
INTERPRO | Zinc finger, NHR/GATA- type | 19 | 4.07 | 8.68E-16 | PPARA, PPARD, AR, RARG, THRA, THRB, PPARG, ESRRG, ESR1, NR3C1, ESR2, NR1H2, PGR, VDR, NR1I3, NR1I2, RARB, NR1H4, NR1H3 | 13.32 | 7.25E-14 | 1.39E-12 |
GOTERM_MF_FAT | Ligand-dependent nuclear receptor activity | 20 | 4.28 | 3.24E-14 | PPARA, PPARD, AR, RARG, THRA, THRB, RXRA, PPARG, ESRRG, ESR1, NR3C1, ESR2, NR1H2, PGR, VDR, NR1I3, NR1I2, RARB, NR1H4, NR1H3 | 9.95 | 2.29E-12 | 5.01E-11 |
Annotation cluster 5 | Enrichment score: 15.83 | |||||||
SP_PIR_KEYWORDS | Protease | 60 | 12.85 | 5.06E-25 | SPG7, METAP1, METAP2, MMP-9, IDE, MMP-8, MMP-7, MMP-3, MMP-1, MMP-20, APP, CASP3, LPA, HTRA1, CASP7, CASP8, CPA1, CFD, CASP1, TPSB2, DPP4, F11, F10, GZMA, ELANE, F9, GZMB, MMP-16, CTSS, F7, MMP-13, MMP-12, NAALAD2, CTSK, FOLH1, BACE2, ST14, BACE1, F2, CTSD, ADAM17, CTSB, ADAMTS5, CTSG, ADAMTS4, PREP, MME, ACE, ECE1, REN, PRSS3, PLAT, CPA4, HPN, KLK5, PLG, LTA4H, CMA1, CPB2, PLAU | 5.11 | 2.43E-23 | 7.34E-22 |
GOTERM_MF_FAT | Endopeptidase activity | 51 | 10.92 | 1.01E-16 | SPG7, MMP-9, IDE, MMP-8, MMP-7, MMP-3, MMP-1, CASP3, MMP-20, LPA, HTRA1, CASP7, CASP8, SERPINE1, CFD, CASP1, TPSB2, DPP4, F11, F10, GZMA, ELANE, F9, GZMB, MMP-16, CTSS, F7, MMP-13, MMP-12, CTSK, BACE2, ST14, F2, BACE1, CTSD, ADAM17, CTSB, ADAMTS5, CTSG, ADAMTS4, PREP, MME, ECE1, REN, PRSS3, PLAT, HPN, KLK5, PLG, CMA1, PLAU | 3.92 | 3.13E-14 | 1.67E-13 |
GOTERM_MF_FAT | Peptidase activity | 62 | 13.28 | 2.65E-15 | SPG7, METAP1, METAP2, MMP-9, IDE, MMP-8, MMP-7, MMP-3, MMP-1, MMP-20, APP, CASP3, LPA, HTRA1, CASP7, CASP8, SERPINE1, CPA1, CFD, CASP1, TPSB2, DPP4, F11, F10, GZMA, ELANE, F9, GZMB, MMP-16, CTSS, F7, MMP-13, MMP-12, NAALAD2, CTSK, FOLH1, BACE2, ST14, BACE1, F2, CTSD, ADAM17, CTSB, CTSG, ADAMTS5, ADAMTS4, PREP, MME, ACE, ECE1, REN, PRSS3, PLAT, CPA4, HPN, KLK5, PLG, QPCT, LTA4H, CMA1, CPB2, PLAU | 3.12 | 3.76E-13 | 4.12E-12 |
GOTERM_MF_FAT | Peptidase activity, acting on L-amino acid peptides | 60 | 12.85 | 4.84E-15 | SPG7, METAP1, METAP2, MMP-9, IDE, MMP-8, MMP-7, MMP-3, MMP-1, MMP-20, CASP3, LPA, HTRA1, CASP7, CASP8, SERPINE1, CPA1, CFD, CASP1, TPSB2, DPP4, F11, F10, GZMA, ELANE, F9, GZMB, MMP-16, CTSS, F7, MMP-13, MMP-12, NAALAD2, CTSK, FOLH1, BACE2, ST14, BACE1, F2, CTSD, ADAM17, CTSB, ADAMTS5, CTSG, ADAMTS4, PREP, MME, ACE, ECE1, REN, PRSS3, PLAT, CPA4, HPN, KLK5, PLG, LTA4H, CMA1, CPB2, PLAU | 3.15 | 5.17E-13 | 7.55E-12 |
GOTERM_BP_FAT | Proteolysis | 76 | 16.27 | 1.10E-10 | METAP1, SPG7, METAP2, TSG101, MMP-9, IDE, MMP-8, MMP-7, MMP-3, C1QC, MMP-1, MMP-20, CASP3, LPA, HTRA1, CASP7, CASP8, CPA1, CASP1, CFD, TPSB2, DPP4, F11, F10, GZMA, ELANE, F9, MMP- 16, UBR2, GZMB, CTSS, F7, MMP-13, MMP-12, C1QA, PRKCQ, C1QB, NAALAD2, CTSK, FOLH1, BACE2, ST14, BACE1, F2, CTSD, ADAM17, MDM2, CTSB, CTSG, ADAMTS5, ADAMTS4, PREP, XIAP, MME, NEDD8, ACE, ECE1, REN, PRSS3, TRAF6, SPOP, PLAT, CPA4, HPN, KLK5, PLG, BRCA1, NAE1, QPCT, VCP, UBA3, CMA1, LTA4H, CPB2, PLAU, UBE2E1 | 2.19 | 1.32E-08 | 2.00E-07 |
Annotation cluster 6 | Enrichment score: 14.64 | |||||||
SP_PIR_KEYWORDS | Serine/threonine protein kinase | 44 | 9.42 | 3.20E-17 | NEK2, MAPKAPK3, TTK, CHEK1, ADRBK1, AURKA, MAPKAPK2, CHEK2, CSNK2A2, IRAK4, AKT1, PDPK1, CSNK2A1, MAP3K9, PAK4, PRKACA, PAK1, AKT2, PRKCA, SGK1, MAP2K1, ROCK1, BRAF, TGFBR1, PIM1, PRKCI, RAF1, CDK6, MAPK10, CDK5, WEE1, CDK2, PRKCB, MAPK1, PRKCQ, RPS6KA1, PLK1, MAPK14, GSK3B, DYRK1A, MAPK3, GRK6, MAPK9, MAPK8 | 4.76 | 1.20E-15 | 4.64E-14 |
INTERPRO | Serine/threonine protein kinase | 38 | 8.14 | 2.09E-16 | NEK2, MAPKAPK3, TTK, CHEK1, ADRBK1, AURKA, MAPKAPK2, CHEK2, CSNK2A2, AKT1, PDPK1, CSNK2A1, PAK4, PRKACA, PAK1, AKT2, PRKCA, SGK1, MAP2K1, ROCK1, PIM1, PRKCI, CDK6, MAPK10, CDK5, CDK2, PRKCB, MAPK1, PRKCQ, RPS6KA1, PLK1, MAPK14, GSK3B, DYRK1A, MAPK3, GRK6, MAPK9, MAPK8 | 5.25 | 2.49E-14 | 3.44E-13 |
INTERPRO | Serine/threonine protein kinase, active site | 44 | 9.42 | 4.17E-16 | NEK2, MAPKAPK3, TTK, CHEK1, ADRBK1, AURKA, MAPKAPK2, CHEK2, CSNK2A2, IRAK4, AKT1, PDPK1, CSNK2A1, MAP3K9, PAK4, PRKACA, PAK1, AKT2, PRKCA, SGK1, MAP2K1, ROCK1, BRAF, TGFBR1, PIM1, PRKCI, RAF1, CDK6, MAPK10, CDK5, WEE1, CDK2, PRKCB, MAPK1, PRKCQ, RPS6KA1, PLK1, MAPK14, GSK3B, DYRK1A, MAPK3, GRK6, MAPK9, MAPK8 | 4.44 | 4.43E-14 | 6.88E-13 |
INTERPRO | Serine/threonine protein kinase related | 44 | 9.42 | 6.21E-16 | NEK2, MAPKAPK3, TTK, CHEK1, ADRBK1, AURKA, MAPKAPK2, CHEK2, CSNK2A2, IRAK4, AKT1, PDPK1, CSNK2A1, MAP3K9, PAK4, PRKACA, PAK1, AKT2, PRKCA, SGK1, MAP2K1, ROCK1, BRAF, TGFBR1, PIM1, PRKCI, RAF1, CDK6, MAPK10, CDK5, WEE1, CDK2, PRKCB, MAPK1, PRKCQ, RPS6KA1, PLK1, MAPK14, GSK3B, DYRK1A, MAPK3, GRK6, MAPK9, MAPK8 | 4.38 | 5.98E-14 | 1.03E-12 |
SMART | S_TKc | 38 | 8.14 | 1.09E-14 | NEK2, MAPKAPK3, TTK, CHEK1, ADRBK1, AURKA, MAPKAPK2, CHEK2, CSNK2A2, AKT1, PDPK1, CSNK2A1, PAK4, PRKACA, PAK1, AKT2, PRKCA, SGK1, MAP2K1, ROCK1, PIM1, PRKCI, CDK6, MAPK10, CDK5, CDK2, PRKCB, MAPK1, PRKCQ, RPS6KA1, PLK1, MAPK14, GSK3B, DYRK1A, MAPK3, GRK6, MAPK9, MAPK8 | 4.55 | 4.57E-13 | 1.32E-11 |
GOTERM_MF_FAT | Protein serine/threonine kinase activity | 47 | 10.06 | 7.51E-12 | CDK5R1, NEK2, MAPKAPK3, TTK, CHEK1, FKBP1A, ADRBK1, AURKA, MAPKAPK2, CHEK2, CSNK2A2, IRAK4, AKT1, PDPK1, CSNK2A1, MAP3K9, PAK4, PRKACA, PAK1, AKT2, EGFR, PRKCA, SGK1, MAP2K1, ROCK1, BRAF, TGFBR1, PIM1, PRKCI, RAF1, CDK6, MAPK10, CDK5, WEE1, CDK2, PRKCB, MAPK1, PRKCQ, RPS6KA1, PLK1, MAPK14, GSK3B, DYRK1A, MAPK3, GRK6, MAPK9, MAPK8 | 3.15 | 3.97E-10 | 1.16E-08 |
Annotation cluster 7 | Enrichment score: 14.56 | |||||||
GOTERM_BP_FAT | Regulation of programmed cell death | 74 | 15.85 | 2.10E-15 | HRAS, MMP-9, PTEN, BTK, AKT1, CASP3, APP, FNTA, TIAM1, CASP8, RARB, CASP1, NQO1, PIK3CG, EGFR, PRKCA, PPP2R1A, NUDT2, RARG, BRAF, ROCK1, RXRA, PIM1, ESR1, TP53, PRKCI, ESR2, F7, CDK5, MAPK1, CD38, NME2, NME1, LCK, F2, MAPK9, ADAM17, MAPK8, CTSB, GSTP1, TRAF2, CDK5R1, YWHAZ, XIAP, ADORA2A, ERBB2, BCL2L1, KIT, NR3C1, SFN, CHEK2, SRC, MIF, VDR, IGF1R, ALB, BCL2, PPP2CA, RAC1, TGM2, BCL6, GLO1, TRAF6, LGALS1, TGFBR1, BIRC7, IGF1, PLG, BRCA1, NAE1, ATP7A, VCP, GSK3B, ABL1, IL2 | 2.76 | 7.55E-13 | 3.83E-12 |
GOTERM_BP_FAT | Regulation of cell death | 74 | 15.85 | 2.52E-15 | HRAS, MMP-9, PTEN, BTK, AKT1, CASP3, APP, FNTA, TIAM1, CASP8, RARB, CASP1, NQO1, PIK3CG, EGFR, PRKCA, PPP2R1A, NUDT2, RARG, BRAF, ROCK1, RXRA, PIM1, ESR1, TP53, PRKCI, ESR2, F7, CDK5, MAPK1, CD38, NME2, NME1, LCK, F2, MAPK9, ADAM17, MAPK8, CTSB, GSTP1, TRAF2, CDK5R1, YWHAZ, XIAP, ADORA2A, ERBB2, BCL2L1, KIT, NR3C1, SFN, CHEK2, SRC, MIF, VDR, IGF1R, ALB, BCL2, PPP2CA, RAC1, TGM2, BCL6, GLO1, TRAF6, LGALS1, TGFBR1, BIRC7, IGF1, PLG, BRCA1, NAE1, ATP7A, VCP, GSK3B, ABL1, IL2 | 2.75 | 8.23E-13 | 4.63E-12 |
GOTERM_BP_FAT | Regulation of apoptosis | 73 | 15.63 | 4.05E-15 | HRAS, MMP-9, PTEN, BTK, AKT1, CASP3, APP, FNTA, TIAM1, CASP8, RARB, CASP1, NQO1, PIK3CG, PRKCA, EGFR, PPP2R1A, NUDT2, RARG, BRAF, ROCK1, RXRA, PIM1, ESR1, TP53, PRKCI, ESR2, F7, CDK5, MAPK1, CD38, NME2, NME1, LCK, F2, MAPK9, ADAM17, MAPK8, CTSB, GSTP1, TRAF2, CDK5R1, YWHAZ, XIAP, ADORA2A, ERBB2, BCL2L1, NR3C1, SFN, CHEK2, SRC, MIF, VDR, IGF1R, ALB, BCL2, PPP2CA, RAC1, TGM2, BCL6, GLO1, TRAF6, LGALS1, TGFBR1, BIRC7, IGF1, PLG, BRCA1, NAE1, ATP7A, VCP, GSK3B, ABL1, IL2 | 2.75 | 1.17E-12 | 7.25E-12 |
Annotation cluster 8 | Enrichment score: 10.94 | |||||||
GOTERM_BP_FAT | Regulation of phosphorylation | 49 | 10.49 | 1.72E-12 | HMGCR, TTK, PTEN, AKT1, CDC42, APP, CASP3, PDPK1, CXCR4, MAP3K9, PRKACA, PAK1, INSR, SYK, PRKCA, EGFR, PPP2R1A, LYN, ELANE, PIM1, RB1, CDK5, NCK2, F2, ADAM17, TRAF2, CDK5R1, ADORA2A, ERBB2, CHEK1, FKBP1A, SFN, KIT, PIN1, PTK2B, PPP2CA, BCL2, RAC1, TRAF6, MAP2K1, TGFBR1, MET, BIRC7, IGF1, PTPN11, ATP7A, FABP4, TNK2, IL2 | 3.19 | 3.25E-10 | 3.12E-09 |
GOTERM_BP_FAT | Regulation of phosphorus metabolic process | 50 | 10.71 | 2.04E-12 | HMGCR, TTK, PTEN, AKT1, CDC42, APP, CASP3, PDPK1, CXCR4, MAP3K9, PRKACA, PAK1, INSR, SYK, PRKCA, EGFR, PPP2R1A, LYN, ELANE, PIM1, RB1, CDK5, NCK2, F2, ADAM17, TRAF2, CDK5R1, ADORA2A, ERBB2, CHEK1, FKBP1A, SFN, KIT, PIN1, PTK2B, PPP2CA, BCL2, RAC1, TRAF6, MAP2K1, PLEK, TGFBR1, MET, BIRC7, IGF1, PTPN11, ATP7A, FABP4, TNK2, IL2 | 3.13 | 3.65E-10 | 3.70E-09 |
GOTERM_BP_FAT | Regulation of phosphate metabolic process | 50 | 10.71 | 2.04E-12 | HMGCR, TTK, PTEN, AKT1, CDC42, APP, CASP3, PDPK1, CXCR4, MAP3K9, PRKACA, PAK1, INSR, SYK, PRKCA, EGFR, PPP2R1A, LYN, ELANE, PIM1, RB1, CDK5, NCK2, F2, ADAM17, TRAF2, CDK5R1, ADORA2A, ERBB2, CHEK1, FKBP1A, SFN, KIT, PIN1, PTK2B, PPP2CA, BCL2, RAC1, TRAF6, MAP2K1, PLEK, TGFBR1, MET, BIRC7, IGF1, PTPN11, ATP7A, FABP4, TNK2, IL2 | 3.13 | 3.65E-10 | 3.70E-09 |
GOTERM_BP_FAT | Regulation of transferase activity | 41 | 8.78 | 3.67E-11 | TRAF2, CDK5R1, HMGCR, ADORA2A, ERBB2, PPARG, CHEK1, SFN, KIT, PTEN, AKT1, CDC42, PDPK1, CASP3, APP, CXCR4, PTK2B, MAP3K9, PPP2CA, RAC1, PRKACA, PAK1, TRAF6, INSR, SYK, EGFR, PRKCA, PPP2R1A, MAP2K1, TGFBR1, ELANE, MET, PIM1, BIRC7, RB1, CDK5, PTPN11, NCK2, FABP4, ADAM17, IL2 | 3.34 | 4.93E-09 | 6.67E-08 |
GOTERM_BP_FAT | Regulation of kinase activity | 40 | 8.56531 | 4.06E-11 | TRAF2, CDK5R1, HMGCR, ADORA2A, ERBB2, CHEK1, SFN, KIT, PTEN, AKT1, CDC42, CASP3, APP, PDPK1, CXCR4, PTK2B, MAP3K9, PPP2CA, RAC1, PRKACA, PAK1, TRAF6, INSR, SYK, EGFR, PRKCA, PPP2R1A, MAP2K1, TGFBR1, ELANE, MET, PIM1, BIRC7, RB1, CDK5, PTPN11, NCK2, FABP4, ADAM17, IL2 | 3.40 | 5.24E-09 | 7.37E-08 |
GOTERM_BP_FAT | Regulation of protein kinase activity | 38 | 8.145 | 2.24E-10 | TRAF2, CDK5R1, HMGCR, ADORA2A, ERBB2, CHEK1, SFN, KIT, PTEN, AKT1, CASP3, APP, PDPK1, CXCR4, PTK2B, MAP3K9, PPP2CA, PRKACA, PAK1, TRAF6, INSR, SYK, EGFR, PRKCA, PPP2R1A, MAP2K1, TGFBR1, ELANE, MET, PIM1, BIRC7, RB1, CDK5, PTPN11, NCK2, FABP4, ADAM17, IL2 | 3.34 | 2.33E-08 | 4.07E-07 |
Annotation cluster 9 | Enrichment score: 10.39 | |||||||
SP_PIR_KEYWORDS | Serine proteinase | 17 | 3.64 | 9.89E-14 | PLAT, F11, PREP, HPN, F10, GZMA, F9, GZMB, F7, PLG, LPA, PRSS3, F2, CMA1, TPSB2, CTSG, PLAU | 12.97 | 2.18E-12 | 1.44E-10 |
UP_SEQ_FEATURE | Charge relay system | 28 | 6.00 | 3.26E-13 | PREP, HMGCR, LPA, HTRA1, BCHE, PRSS3, CFD, TPSB2, DPP4, F11, PLAT, HPN, F10, CES1, GZMA, KLK5, ELANE, F9, GZMB, F7, PLG, NAALAD2, FOLH1, ST14, F2, CMA1, CTSG, PLAU | 5.85 | 4.45E-11 | 5.48E-10 |
SP_PIR_KEYWORDS | Serine protease | 23 | 4.93 | 1.74E-12 | PLAT, F11, PREP, HPN, F10, GZMA, KLK5, ELANE, F9, GZMB, F7, PLG, LPA, HTRA1, ST14, F2, PRSS3, CMA1, TPSB2, CFD, DPP4, CTSG, PLAU | 6.97 | 3.68E-11 | 2.53E-09 |
UP_SEQ_FEATURE | Peptidase S1 | 20 | 4.28 | 9.94E-12 | PLAT, F11, HPN, F10, GZMA, KLK5, ELANE, F9, GZMB, F7, PLG, LPA, ST14, F2, PRSS3, CMA1, TPSB2, CFD, CTSG, PLAU | 7.72 | 1.08E-09 | 1.67E-08 |
INTERPRO | Peptidase S1 and S6, chymotrypsin/Hap | 21 | 4.50 | 6.51E-11 | PLAT, F11, HPN, F10, GZMA, KLK5, ELANE, F9, GZMB, F7, PLG, LPA, HTRA1, ST14, F2, PRSS3, CMA1, TPSB2, CFD, CTSG, PLAU | 6.47 | 4.50E-09 | 1.01E-07 |
INTERPRO | Peptidase S1A, chymotrypsin | 20 | 4.28 | 6.91E-11 | PLAT, F11, HPN, F10, GZMA, KLK5, ELANE, F9, GZMB, F7, PLG, LPA, ST14, F2, PRSS3, CMA1, TPSB2, CFD, CTSG, PLAU | 6.87 | 4.43E-09 | 1.08E-07 |
INTERPRO | Peptidase S1/S6, chymotrypsin/Hap, active site | 20 | 4.28 | 8.22E-11 | PLAT, F11, HPN, F10, GZMA, KLK5, ELANE, F9, GZMB, F7, PLG, LPA, ST14, F2, PRSS3, CMA1, TPSB2, CFD, CTSG, PLAU | 6.81 | 4.92E-09 | 1.28E-07 |
GOTERM_MF_FAT | Serine-type endopeptidase activity | 25 | 5.35 | 5.61E-10 | PREP, MMP-8, LPA, HTRA1, PRSS3, SERPINE1, CFD, TPSB2, DPP4, F11, PLAT, HPN, F10, GZMA, KLK5, ELANE, F9, GZMB, F7, PLG, F2, ST14, CMA1, CTSG, PLAU | 4.68 | 2.26E-08 | 8.67E-07 |
SMART | Tryp_SPc | 21 | 4.50 | 6.36E-10 | PLAT, F11, HPN, F10, GZMA, KLK5, ELANE, F9, GZMB, F7, PLG, LPA, HTRA1, ST14, F2, PRSS3, CMA1, TPSB2, CFD, CTSG, PLAU | 5.61 | 2.14E-08 | 7.74E-07 |
GOTERM_MF_FAT | Serine-type peptidase activity | 26 | 5.57 | 2.29E-09 | PREP, MMP-8, LPA, HTRA1, PRSS3, SERPINE1, CFD, TPSB2, DPP4, F11, PLAT, HPN, F10, GZMA, KLK5, ELANE, F9, GZMB, F7, PLG, NAALAD2, ST14, F2, CMA1, CTSG, PLAU | 4.21 | 8.44E-08 | 3.55E-06 |
GOTERM_MF_FAT | Serine hydrolase activity | 26 | 5.57 | 2.90E-09 | PREP, MMP-8, LPA, HTRA1, PRSS3, SERPINE1, CFD, TPSB2, DPP4, F11, PLAT, HPN, F10, GZMA, KLK5, ELANE, F9, GZMB, F7, PLG, NAALAD2, ST14, F2, CMA1, CTSG, PLAU | 4.17 | 1.02E-07 | 4.49E-06 |
Annotation cluster 10 | Enrichment score: 9.02 | |||||||
GOTERM_BP_FAT | Negative regulation of programmed cell death | 38 | 8.4 | 6.92E-10 | YWHAZ, HRAS, XIAP, ADORA2A, ERBB2, BCL2L1, KIT, PTEN, MIF, AKT1, IGF1R, CASP3, FNTA, ALB, BCL2, TGM2, GLO1, BCL6, TRAF6, PIK3CG, EGFR, ROCK1, BRAF, TGFBR1, PIM1, BIRC7, PRKCI, TP53, ESR1, IGF1, F7, ESR2, NME2, NME1, GSK3B, ADAM17, MAPK8, GSTP1, IL2 | 3.21 | 6.76E-08 | 1.26E-06 |
GOTERM_BP_FAT | Negative regulation of cell death | 38 | 8.14 | 7.49E-10 | YWHAZ, HRAS, XIAP, ADORA2A, ERBB2, BCL2L1, KIT, PTEN, MIF, AKT1, IGF1R, CASP3, FNTA, ALB, BCL2, TGM2, GLO1, BCL6, TRAF6, PIK3CG, EGFR, ROCK1, BRAF, TGFBR1, PIM1, BIRC7, PRKCI, TP53, ESR1, IGF1, F7, ESR2, NME2, NME1, GSK3B, ADAM17, MAPK8, GSTP1, IL2 | 3.20 | 7.10E-08 | 1.36E-06 |
GOTERM_BP_FAT | Negative regulation of apoptosis | 37 | 7.92 | 1.71E-09 | YWHAZ, HRAS, XIAP, ADORA2A, ERBB2, BCL2L1, PTEN, MIF, AKT1, IGF1R, CASP3, FNTA, ALB, BCL2, TGM2, GLO1, BCL6, TRAF6, EGFR, PIK3CG, ROCK1, BRAF, TGFBR1, PIM1, BIRC7, PRKCI, TP53, ESR1, IGF1, F7, ESR2, NME2, NME1, GSK3B, ADAM17, MAPK8, GSTP1, IL2 | 3.17 | 1.31E-07 | 3.11E-06 |
Annotation cluster 11 | Enrichment score: 8.99 | |||||||
GOTERM_BP_FAT | Positive regulation of apoptosis | 42 | 8.99 | 8.49E-10 | TRAF2, CDK5R1, ADORA2A, MMP-9, BCL2L1, CHEK2, SFN, NR3C1, PTEN, SRC, BTK, AKT1, VDR, APP, CASP3, TIAM1, PPP2CA, BCL2, CASP8, RAC1, TGM2, BCL6, RARB, CASP1, TRAF6, NQO1, PRKCA, PPP2R1A, NUDT2, RARG, TGFBR1, RXRA, TP53, CDK5, BRCA1, PLG, MAPK1, CD38, LCK, MAPK9, MAPK8, ABL1 | 2.96 | 7.82E-08 | 1.54E-06 |
GOTERM_BP_FAT | Positive regulation of programmed cell death | 42 | 8.99 | 1.05E-09 | TRAF2, CDK5R1, ADORA2A, MMP-9, BCL2L1, CHEK2, SFN, NR3C1, PTEN, SRC, BTK, AKT1, VDR, APP, CASP3, TIAM1, PPP2CA, BCL2, CASP8, RAC1, TGM2, BCL6, RARB, CASP1, TRAF6, NQO1, PRKCA, PPP2R1A, NUDT2, RARG, TGFBR1, RXRA, TP53, CDK5, BRCA1, PLG, MAPK1, CD38, LCK, MAPK9, MAPK8, ABL1 | 2.94 | 8.87E-08 | 1.90E-06 |
GOTERM_BP_FAT | Positive regulation of cell death | 42 | 8.99 | 1.20E-09 | TRAF2, CDK5R1, ADORA2A, MMP-9, BCL2L1, CHEK2, SFN, NR3C1, PTEN, SRC, BTK, AKT1, VDR, APP, CASP3, TIAM1, PPP2CA, BCL2, CASP8, RAC1, TGM2, BCL6, RARB, CASP1, TRAF6, NQO1, PRKCA, PPP2R1A, NUDT2, RARG, TGFBR1, RXRA, TP53, CDK5, BRCA1, PLG, MAPK1, CD38, LCK, MAPK9, MAPK8, ABL1 | 2.93 | 9.91E-08 | 2.18E-06 |
Annotation cluster 12 | Enrichment score: 8.97 | |||||||
GOTERM_BP_FAT | Regulation of cell motion | 28 | 6.00 | 1.90E-10 | NRP1, ERBB4, MMP-9, KIT, PTEN, AKT1, IGF1R, ACE, PTK2B, CXCR4, BCL2, TEK, RAC1, BCL6, INSR, EGFR, F10, LYN, MAP2K1, TGFBR1, IGF1, F7, CDK5, PLG, KDR, MAPK1, ADAM17, HDAC7 | 4.40 | 2.04E-08 | 3.45E-07 |
GOTERM_BP_FAT | Regulation of locomotion | 27 | 5.78 | 8.53E-10 | ERBB4, ADORA2A, MMP-9, KIT, PTEN, AKT1, IGF1R, ACE, PTK2B, CXCR4, BCL2, TEK, RAC1, INSR, PRKCA, EGFR, F10, MAP2K1, ELANE, IGF1, F7, CDK5, PLG, KDR, MAPK1, ADAM17, HDAC7 | 4.27 | 7.64E-08 | 1.55E-06 |
GOTERM_BP_FAT | Regulation of cell migration | 24 | 5.14 | 7.40E-09 | EGFR, F10, ERBB4, MAP2K1, MMP-9, IGF1, KIT, F7, CDK5, PTEN, PLG, KDR, AKT1, MAPK1, IGF1R, ACE, CXCR4, PTK2B, BCL2, TEK, RAC1, ADAM17, INSR, HDAC7 | 4.31 | 5.08E-07 | 1.34E-05 |
Annotation cluster 13 | Enrichment score: 8.68 | |||||||
UP_SEQ_FEATURE | GST N-terminal | 12 | 2.57 | 4.56E-13 | GSTM1, GSTA1, GSTM2, GSTA2, GSTA3, GSTA4, GSTZ1, GSTT1, GSTO2, GSTO1, HPGDS, GSTP1 | 23.39 | 5.74E-11 | 7.65E-10 |
INTERPRO | Glutathione S-transferase, N-terminal | 12 | 2.57 | 3.81E-12 | GSTM1, GSTA1, GSTM2, GSTA2, GSTA3, GSTA4, GSTZ1, GSTT1, GSTO2, GSTO1, HPGDS, GSTP1 | 19.50 | 2.85E-10 | 5.94E-09 |
GOTERM_MF_FAT | Glutathione transferase activity | 12 | 2.57 | 9.51E-12 | GSTM1, GSTA1, GSTM2, GSTA2, GSTA3, GSTA4, GSTK1, GSTZ1, GSTT1, GSTO2, GSTO1, GSTP1 | 17.31 | 4.47E-10 | 1.47E-08 |
UP_SEQ_FEATURE | GST C-terminal | 12 | 2.57 | 1.92E-10 | GSTM1, GSTA1, GSTM2, GSTA2, GSTA3, GSTA4, GSTZ1, GSTT1, GSTO2, GSTO1, HPGDS, GSTP1 | 14.88 | 1.96E-08 | 3.22E-07 |
INTERPRO | Glutathione S-transferase, C-terminal | 10 | 2.14 | 2.08E-09 | GSTM1, GSTA1, GSTM2, GSTA2, GSTA3, GSTA4, GSTZ1, GSTT1, GSTO1, GSTP1 | 17.02 | 1.17E-07 | 3.24E-06 |
INTERPRO | Glutathione S-transferase, C-terminal-like | 11 | 2.36 | 3.25E-09 | GSTM1, GSTA1, GSTM2, GSTA2, GSTA3, GSTA4, GSTZ1, GSTT1, GSTO2, GSTO1, GSTP1 | 13.56 | 1.71E-07 | 5.06E-06 |
INTERPRO | Glutathione S-transferase/chloride channel, C-terminal | 11 | 2.36 | 4.75E-09 | GSTM1, GSTA1, GSTM2, GSTA2, GSTA3, GSTA4, GSTZ1, GSTT1, GSTO2, GSTO1, GSTP1 | 13.11 | 2.37E-07 | 7.40E-06 |
KEGG_PATHWAY | Glutathione metabolism | 14 | 3.00 | 1.57E-05 | GSTA1, GSTA2, ODC1, GSTA3, GSTA4, GSTT1, GSTM1, GSTM2, G6PD, GSTK1, GSTZ1, GSTO2, GSTO1, GSTP1 | 4.18 | 9.77E-05 | 0.018816 |
INTERPRO | Thioredoxin fold | 11 | 2.356 | 5.18E-04 | GSTM1, GSTA1, GSTM2, GSTA2, GSTA3, GSTA4, GSTZ1, GSTT1, GSTO2, GSTO1, GSTP1 | 3.90 | 0.01217529 | 0.804529 |
Annotation cluster 14 | Enrichment score: 7.42 | |||||||
GOTERM_BP_FAT | Positive regulation of cell motion | 19 | 4.07 | 2.63E-09 | EGFR, F10, ERBB4, LYN, MAP2K1, MMP-9, TGFBR1, IGF1, KIT, F7, KDR, IGF1R, MAPK1, PTK2B, BCL2, ADAM17, BCL6, INSR, HDAC7 | 5.88 | 1.97E-07 | 4.77E-06 |
GOTERM_BP_FAT | Positive regulation of locomotion | 17 | 3.64 | 1.14E-07 | PRKCA, EGFR, F10, ERBB4, MAP2K1, MMP-9, IGF1, F7, KIT, KDR, IGF1R, MAPK1, PTK2B, BCL2, ADAM17, INSR, HDAC7 | 5.26 | 5.58E-06 | 2.07E-04 |
GOTERM_BP_FAT | Positive regulation of cell migration | 16 | 3.43 | 1.85E-07 | EGFR, F10, ERBB4, MAP2K1, MMP-9, IGF1, F7, KIT, KDR, IGF1R, MAPK1, PTK2B, BCL2, ADAM17, INSR, HDAC7 | 5.45 | 8.90E-06 | 3.36E-04 |
Annotation cluster 15 | Enrichment score: 7.15 | |||||||
SP_PIR_KEYWORDS | SH2 domain | 17 | 3.64 | 1.08E-08 | ITK, LYN, GRB2, HCK, SRC, PTPN11, BTK, TYK2, NCK2, DAPP1, FYN, LCK, ZAP70, JAK1, JAK3, ABL1, SYK | 6.31 | 1.89E-07 | 1.56E-05 |
INTERPRO | SH2 domain | 17 | 3.64 | 7.50E-08 | ITK, LYN, GRB2, HCK, SRC, PTPN11, BTK, TYK2, NCK2, DAPP1, FYN, LCK, ZAP70, JAK1, JAK3, ABL1, SYK | 5.48 | 3.06E-06 | 1.17E-04 |
SMART | SH2 domain | 17 | 3.64 | 4.51E-07 | ITK, LYN, GRB2, HCK, SRC, PTPN11, BTK, TYK2, NCK2, DAPP1, FYN, LCK, ZAP70, JAK1, JAK3, ABL1, SYK | 4.75 | 1.26E-05 | 5.49E-04 |
Annotation cluster 16 | Enrichment score: 7.12 | |||||||
GOTERM_BP_FAT | Cell migration | 31 | 6.64 | 8.87E-09 | PPARD, CDK5R1, NRP1, HMGCR, PEX5, KIT, PTEN, SRC, PTK2, GAB2, CXCR4, PTK2B, PRSS3, RAC1, SFTPD, SYK, PRKCA, PLAT, RET, ROCK1, TGFBR1, MET, ELANE, ESR2, CDK5, KDR, NCK2, FYN, ADAM17, SDCBP, PLAU | 3.41 | 5.84E-07 | 1.61E-05 |
GOTERM_BP_FAT | Cell motility | 31 | 6.64 | 9.98E-08 | PPARD, CDK5R1, NRP1, HMGCR, PEX5, KIT, PTEN, SRC, PTK2, GAB2, CXCR4, PTK2B, PRSS3, RAC1, SFTPD, SYK, PRKCA, PLAT, RET, ROCK1, TGFBR1, MET, ELANE, ESR2, CDK5, KDR, NCK2, FYN, ADAM17, SDCBP, PLAU | 3.06 | 4.95E-06 | 1.81E-04 |
GOTERM_BP_FAT | Localization of cell | 31 | 6.64 | 9.98E-08 | PPARD, CDK5R1, NRP1, HMGCR, PEX5, KIT, PTEN, SRC, PTK2, GAB2, CXCR4, PTK2B, PRSS3, RAC1, SFTPD, SYK, PRKCA, PLAT, RET, ROCK1, TGFBR1, MET, ELANE, ESR2, CDK5, KDR, NCK2, FYN, ADAM17, SDCBP, PLAU | 3.06 | 4.95E-06 | 1.81E-04 |
GOTERM_BP_FAT | Cell motion | 39 | 8.35 | 3.80E-07 | ITGAL, PPARD, CDK5R1, NRP1, HMGCR, ERBB2, PEX5, KIT, PTEN, SRC, APP, PTK2, GAB2, CXCR4, PTK2B, PAK4, PRSS3, RAC1, SFTPD, SYK, PLAT, PRKCA, RET, MAP2K1, ROCK1, TGFBR1, ELANE, MET, IGF1, ESR2, CDK5, KDR, NCK2, FYN, MAPK14, ADAM17, SDCBP, MAPK8, PLAU | 2.49 | 1.68E-05 | 6.90E-04 |
Annotation cluster 17 | Enrichment score: 7.03 | |||||||
UP_SEQ_FEATURE | Short sequence motif: cysteine switch | 12 | 2.57 | 4.58E-09 | MMP-20, MMP-9, MMP-8, MMP-7, ADAM17, MMP-16, MMP-3, MMP-13, ADAMTS5, MMP-12, MMP-1, ADAMTS4 | 11.42 | 4.41E-07 | 7.69E-06 |
INTERPRO | Peptidase M, neutral zinc metallopeptidases, zinc- binding site | 16 | 3.43 | 6.40E-08 | MMP-9, MMP-8, MMP-7, MME, MMP-16, MMP-3, MMP-13, MMP-1, MMP-12, ACE, MMP-20, ECE1, ADAM17, LTA4H, ADAMTS5, ADAMTS4 | 5.96 | 2.74E-06 | 9.97E-05 |
GOTERM_MF_FAT | Metalloendopeptidase activity | 16 | 3.43 | 2.72E-06 | SPG7, MMP-9, IDE, MMP-8, MMP-7, MME, MMP-16, MMP-3, MMP-13, MMP-1, MMP-12, MMP-20, ECE1, ADAM17, ADAMTS5, ADAMTS4 | 4.44 | 7.42E-05 | 0.004202 |
Annotation cluster 18 | Enrichment score: 6.95 | |||||||
GOTERM_BP_FAT | Positive regulation of kinase activity | 27 | 5.78 | 4.35E-08 | TRAF2, ADORA2A, ERBB2, KIT, AKT1, CDC42, PDPK1, PTK2B, CXCR4, MAP3K9, RAC1, PRKACA, PAK1, TRAF6, INSR, SYK, EGFR, MAP2K1, TGFBR1, MET, ELANE, BIRC7, PIM1, CDK5, PTPN11, ADAM17, IL2 | 3.55 | 2.46E-06 | 7.90E-05 |
GOTERM_BP_FAT | Positive regulation of transferase activity | 27 | 5.78 | 9.47E-08 | TRAF2, ADORA2A, ERBB2, KIT, AKT1, CDC42, PDPK1, PTK2B, CXCR4, MAP3K9, RAC1, PRKACA, PAK1, TRAF6, INSR, SYK, EGFR, MAP2K1, TGFBR1, MET, ELANE, BIRC7, PIM1, CDK5, PTPN11, ADAM17, IL2 | 3.41 | 4.77E-06 | 1.72E-04 |
GOTERM_BP_FAT | Positive regulation of protein kinase activity | 25 | 5.35 | 3.34E-07 | TRAF2, ADORA2A, ERBB2, KIT, AKT1, PDPK1, PTK2B, CXCR4, MAP3K9, PRKACA, PAK1, TRAF6, INSR, SYK, EGFR, MAP2K1, TGFBR1, MET, ELANE, BIRC7, PIM1, CDK5, PTPN11, ADAM17, IL2 | 3.40 | 1.49E-05 | 6.05E-04 |
Annotation cluster 19 | Enrichment score: 6.74 | |||||||
GOTERM_BP_FAT | Positive regulation of biosynthetic process | 52 | 11.13 | 5.71E-08 | HSP90AB1, PPARA, HRAS, THRA, THRB, PPARG, AKT1, APP, FNTA, RARB, KDM5A, DDAH1, INSR, AKT2, SYK, EGFR, AR, RARG, HSP90AA1, RXRA, ELANE, TP53, RB1, ESR2, PPARGC1A, CDK2, TNKS2, PRKCQ, MAPK1, NCOA1, NCOA2, F2, ADORA2A, ARNT, NR1H2, IGF1R, TNFRSF1A, PTK2B, TRAF6, NR1H4, NR1H3, BCKDHA, EPAS1, TGFBR1, ESRRG, IGF1, BRCA1, HDAC4, HDAC2, MAPK14, JAK3, IL2 | 2.27 | 3.07E-06 | 1.04E-04 |
GOTERM_BP_FAT | Positive regulation of nitrogen compound metabolic process | 49 | 10.49 | 9.00E-08 | HSP90AB1, PPARA, NCBP1, HRAS, THRA, THRB, PPARG, AKT1, APP, RARB, KDM5A, DDAH1, INSR, EGFR, AR, RARG, HSP90AA1, RXRA, TP53, CD40, ESR2, RB1, PPARGC1A, CDK2, TNKS2, MAPK1, NCOA1, NCOA2, ADORA2A, COMT, HPRT1, ARNT, NR1H2, IGF1R, TNFRSF1A, NR1H4, NR1H3, BCKDHA, MAP2K1, EPAS1, TGFBR1, ESRRG, IGF1, BRCA1, HDAC4, HDAC2, MAPK14, JAK3, IL2 | 2.31 | 4.61E-06 | 1.63E-04 |
GOTERM_BP_FAT | Positive regulation of cellular biosynthetic process | 50 | 10.71 | 2.34E-07 | HSP90AB1, PPARA, HRAS, THRA, THRB, PPARG, AKT1, APP, RARB, KDM5A, DDAH1, INSR, AKT2, SYK, EGFR, AR, RARG, HSP90AA1, RXRA, ELANE, TP53, RB1, ESR2, PPARGC1A, CDK2, TNKS2, PRKCQ, MAPK1, NCOA1, NCOA2, ADORA2A, ARNT, NR1H2, IGF1R, TNFRSF1A, PTK2B, TRAF6, NR1H4, NR1H3, BCKDHA, EPAS1, TGFBR1, ESRRG, IGF1, BRCA1, HDAC4, HDAC2, MAPK14, JAK3, IL2 | 2.21 | 1.11E-05 | 4.24E-04 |
GOTERM_BP_FAT | Positive regulation of macromolecule biosynthetic process | 47 | 10.06 | 9.04E-07 | PPARA, HRAS, THRA, THRB, PPARG, ARNT, AKT1, NR1H2, IGF1R, TNFRSF1A, APP, FNTA, PTK2B, RARB, KDM5A, TRAF6, INSR, NR1H4, AKT2, SYK, NR1H3, BCKDHA, AR, RARG, EPAS1, TGFBR1, RXRA, ELANE, ESRRG, TP53, IGF1, RB1, ESR2, PPARGC1A, BRCA1, CDK2, TNKS2, HDAC4, MAPK1, PRKCQ, NCOA1, HDAC2, NCOA2, MAPK14, F2, JAK3, IL2 | 2.18 | 3.73E-05 | 0.001641 |
Annotation cluster 20 | Enrichment score: 6.14 | |||||||
UP_SEQ_FEATURE | AGC-kinase C-terminal | 12 | 2.57 | 7.32E-08 | PRKCA, AKT1, PRKCQ, SGK1, ROCK1, RPS6KA1, GRK6, PRKCI, PRKACA, ADRBK1, PRKCB, AKT2 | 8.93 | 5.99E-06 | 1.23E-04 |
INTERPRO | AGC-kinase, C-terminal | 12 | 2.57 | 2.81E-07 | PRKCA, AKT1, PRKCQ, SGK1, ROCK1, RPS6KA1, GRK6, PRKCI, PRKACA, ADRBK1, PRKCB, AKT2 | 7.80 | 1.05E-05 | 4.38E-04 |
SMART | S_TK_X | 12 | 2.57 | 1.07E-06 | PRKCA, AKT1, PRKCQ, SGK1, ROCK1, RPS6KA1, GRK6, PRKCI, PRKACA, ADRBK1, PRKCB, AKT2 | 6.76 | 2.25E-05 | 0.001302 |
INTERPRO | Protein kinase, C-terminal | 9 | 1.93 | 1.22E-05 | PRKCA, AKT1, PRKCQ, SGK1, ROCK1, RPS6KA1, PRKCI, PRKCB, AKT2 | 8.04 | 3.31E-04 | 0.018952 |
Annotation cluster 21 | Enrichment score: 5.96 | |||||||
INTERPRO | 3′,5′-Cyclic nucleotide phosphodiesterase | 9 | 1.93 | 5.13E-08 | PDE2A, PDE7A, PDE4A, PDE4B, PDE5A, PDE3B, PDE9A, PDE4D, PDE8A | 15.32 | 2.30E-06 | 8.00E-05 |
INTERPRO | Metal-dependent phosphohydrolase, HD region | 9 | 1.93 | 1.72E-07 | PDE2A, PDE7A, PDE4A, PDE4B, PDE5A, PDE3B, PDE9A, PDE4D, PDE8A | 13.41 | 6.73E-06 | 2.68E-04 |
UP_SEQ_FEATURE | Metal ion-binding site: divalent metal cation 2 | 9 | 1.93 | 2.38E-07 | PDE2A, PDE7A, PDE4A, PDE4B, PDE5A, PDE3B, PDE9A, PDE4D, PDE8A | 13.16 | 1.86E-05 | 4.00E-04 |
UP_SEQ_FEATURE | Metal ion-binding site: divalent metal cation 1 | 9 | 1.93 | 2.38E-07 | PDE2A, PDE7A, PDE4A, PDE4B, PDE5A, PDE3B, PDE9A, PDE4D, PDE8A | 13.16 | 1.86E-05 | 4.00E-04 |
SMART | HDc | 9 | 1.93 | 4.89E-07 | PDE2A, PDE7A, PDE4A, PDE4B, PDE5A, PDE3B, PDE9A, PDE4D, PDE8A | 11.62 | 1.17E-05 | 5.95E-04 |
GOTERM_MF_FAT | 3′,5′-Cyclic-nucleotide phosphodiesterase activity | 9 | 1.93 | 8.68E-07 | PDE2A, PDE7A, PDE4A, PDE4B, PDE5A, PDE3B, PDE9A, PDE4D, PDE8A | 10.82 | 2.53E-05 | 0.001342 |
GOTERM_MF_FAT | Cyclic-nucleotide phosphodiesterase activity | 9 | 1.93 | 1.24E-06 | PDE2A, PDE7A, PDE4A, PDE4B, PDE5A, PDE3B, PDE9A, PDE4D, PDE8A | 10.39 | 3.49E-05 | 0.001915 |
GOTERM_MF_FAT | Phosphoric diester hydrolase activity | 9 | 1.93 | 0.008435 | PDE2A, PDE7A, PDE4A, PDE4B, PDE5A, PDE3B, PDE9A, PDE4D, PDE8A | 3.09 | 0.08777958 | 12.27639 |
Annotation cluster 22 | Enrichment score: 5.80 | |||||||
UP_SEQ_FEATURE | Short sequence motif: cysteine switch | 12 | 2.57 | 4.58E-09 | MMP-20, MMP-9, MMP-8, MMP-7, ADAM17, MMP-16, MMP-3, MMP-13, ADAMTS5, MMP-12, MMP-1, ADAMTS4 | 11.42 | 4.41E-07 | 7.69E-06 |
INTERPRO | Peptidoglycan binding like | 9 | 1.93 | 3.26E-08 | MMP-20, MMP-9, MMP-8, MMP-7, MMP-16, MMP-3, MMP-13, MMP-12, MMP-1 | 16.09 | 1.54E-06 | 5.07E-05 |
UP_SEQ_FEATURE | Hemopexin-like 4 domain | 8 | 1.71 | 6.08E-07 | MMP-20, MMP-9, MMP-8, MMP-16, MMP-3, MMP-13, MMP-12, MMP-1 | 14.88 | 4.15E-05 | 0.001021 |
UP_SEQ_FEATURE | Hemopexin-like 3 domain | 8 | 1.71 | 6.08E-07 | MMP-20, MMP-9, MMP-8, MMP-16, MMP-3, MMP-13, MMP-12, MMP-1 | 14.88 | 4.15E-05 | 0.001021 |
UP_SEQ_FEATURE | Hemopexin-like 1 domain | 8 | 1.71 | 8.56E-07 | MMP-20, MMP-9, MMP-8, MMP-16, MMP-3, MMP-13, MMP-12, MMP-1 | 14.24 | 5.39E-05 | 0.001437 |
UP_SEQ_FEATURE | Hemopexin-like 2 domain | 8 | 1.71 | 8.56E-07 | MMP-20, MMP-9, MMP-8, MMP-16, MMP-3, MMP-13, MMP-12, MMP-1 | 14.24 | 5.39E-05 | 0.001437 |
INTERPRO | Peptidase, metallopeptidases | 9 | 1.93 | 8.89E-07 | MMP-20, MMP-9, MMP-8, MMP-7, MMP-16, MMP-3, MMP-13, MMP-12, MMP-1 | 11.09 | 3.07E-05 | 0.001385 |
INTERPRO | Hemopexin/matrixin, repeat | 8 | 1.71 | 2.10E-06 | MMP-20, MMP-9, MMP-8, MMP-16, MMP-3, MMP-13, MMP-12, MMP-1 | 12.43 | 6.73E-05 | 0.003271 |
INTERPRO | Hemopexin/matrixin, conserved site | 8 | 1.71 | 2.10E-06 | MMP-20, MMP-9, MMP-8, MMP-16, MMP-3, MMP-13, MMP-12, MMP-1 | 12.43 | 6.73E-05 | 0.003271 |
INTERPRO | Hemopexin/matrixin | 8 | 1.71 | 2.10E-06 | MMP-20, MMP-9, MMP-8, MMP-16, MMP-3, MMP-13, MMP-12, MMP-1 | 12.43 | 6.73E-05 | 0.003271 |
INTERPRO | Peptidase M10A and M12B, matrixin and adamalysin | 10 | 2.14 | 2.31E-06 | MMP-20, MMP-9, MMP-8, MMP-7, ADAM17, MMP-16, MMP-3, MMP-13, MMP-12, MMP-1 | 8.31 | 7.15E-05 | 0.003597 |
SMART | ZnMc | 9 | 1.93 | 2.48E-06 | MMP-20, MMP-9, MMP-8, MMP-7, MMP-16, MMP-3, MMP-13, MMP-12, MMP-1 | 9.62 | 4.63E-05 | 0.003017 |
SMART | HX | 8 | 1.71 | 5.21E-06 | MMP-20, MMP-9, MMP-8, MMP-16, MMP-3, MMP-13, MMP-12, MMP-1 | 10.78 | 8.76E-05 | 0.006349 |
INTERPRO | Peptidase M10A, matrix metallopeotidase | 7 | 1.50 | 6.39E-06 | MMP-20, MMP-8, MMP-16, MMP-3, MMP-13, MMP-12, MMP-1 | 13.90 | 1.85E-04 | 0.009958 |
PIR_SUPERFAMILY | Peptidase_M10A_matrix | 7 | 1.50 | 1.06E-04 | MMP-20, MMP-8, MMP-16, MMP-3, MMP-13, MMP-12, MMP-1 | 8.41 | 0.00874563 | 0.144244 |
PIR_SUPERFAMILY | Matrix metalloproteinase, stromelysin type | 6 | 1.28 | 2.87E-04 | MMP-20, MMP-8, MMP-16, MMP-3, MMP-13, MMP-1 | 9.27 | 0.01875986 | 0.388252 |
Annotation cluster 23 | Enrichment score: 5.73 | |||||||
UP_SEQ_FEATURE | Metal ion-binding site: calcium 3; via carbonyl oxygen | 8 | 1.71 | 4.23E-07 | PRKCA, MMP-9, MMP-8, MMP-3, MMP-13, MMP-12, MMP-1, PRKCB | 15.59 | 3.01E-05 | 7.11E-04 |
UP_SEQ_FEATURE | Metal ion-binding site: calcium 1 | 10 | 2.14 | 1.15E-06 | PRKCA, APCS, MMP-9, MMP-8, MMP-7, MMP-3, MMP-13, MMP-12, MMP-1, PRKCB | 9.09 | 6.70E-05 | 0.001923 |
UP_SEQ_FEATURE | Metal ion-binding site: calcium 2; via carbonyl oxygen | 9 | 1.93 | 3.72E-06 | PRKCA, MMP-9, MMP-8, MMP-7, MMP-3, MMP-13, MMP-12, MMP-1, PRKCB | 9.44 | 1.90E-04 | 0.006252 |
UP_SEQ_FEATURE | Metal ion-binding site: calcium 2 | 10 | 2.14 | 6.62E-06 | PRKCA, APCS, MMP-9, MMP-8, MMP-7, MMP-3, MMP-13, MMP-12, MMP-1, PRKCB | 7.44 | 3.19E-04 | 0.011118 |
Annotation cluster 24 | Enrichment score: 5.69 | |||||||
UP_SEQ_FEATURE | Metal ion-binding site: zinc 2; catalytic | 8 | 1.71 | 1.45E-08 | ACE, MMP-9, MMP-8, MMP-7, MMP-3, MMP-13, MMP-12, MMP-1 | 23.39 | 1.32E-06 | 2.43E-05 |
INTERPRO | Peptidoglycan binding like | 9 | 1.93 | 3.26E-08 | MMP-20, MMP-9, MMP-8, MMP-7, MMP-16, MMP-3, MMP-13, MMP-12, MMP-1 | 16.09 | 1.54E-06 | 5.07E-05 |
UP_SEQ_FEATURE | Metal ion-binding site: zinc 2; in inhibited form | 7 | 1.50 | 3.93E-08 | MMP-9, MMP-8, MMP-7, MMP-3, MMP-13, MMP-12, MMP-1 | 28.65 | 3.39E-06 | 6.60E-05 |
SP_PIR_KEYWORDS | Metalloproteinase | 9 | 1.93 | 5.85E-08 | ACE, MMP-9, MMP-8, MMP-7, MME, MMP-3, MMP-13, MMP-12, MMP-1 | 15.45 | 9.65E-07 | 8.48E-05 |
INTERPRO | Peptidase, metallopeptidases | 9 | 1.93 | 8.89E-07 | MMP-20, MMP-9, MMP-8, MMP-7, MMP-16, MMP-3, MMP-13, MMP-12, MMP-1 | 11.09 | 3.07E-05 | 0.001385 |
SP_PIR_KEYWORDS | Collagen degradation | 7 | 1.50 | 1.93E-06 | MMP-9, MMP-8, MMP-7, MMP-16, MMP-3, MMP-13, MMP-1 | 16.96 | 2.43E-05 | 0.002803 |
SMART | ZnMc | 9 | 1.93 | 2.48E-06 | MMP-20, MMP-9, MMP-8, MMP-7, MMP-16, MMP-3, MMP-13, MMP-12, MMP-1 | 9.62 | 4.63E-05 | 0.003017 |
GOTERM_BP_FAT | Multicellular organismal catabolic process | 8 | 1.71 | 1.52E-05 | ACE, MMP-9, MMP-8, MMP-7, MMP-16, MMP-3, MMP-13, MMP-1 | 9.33 | 4.29E-04 | 0.027575 |
GOTERM_BP_FAT | Collagen catabolic process | 7 | 1.50 | 3.21E-05 | MMP-9, MMP-8, MMP-7, MMP-16, MMP-3, MMP-13, MMP-1 | 10.62 | 7.95E-04 | 0.058172 |
GOTERM_BP_FAT | Multicellular organismal macromolecule metabolic process | 8 | 1.71 | 5.27E-05 | ACE, MMP-9, MMP-8, MMP-7, MMP-16, MMP-3, MMP-13, MMP-1 | 7.83 | 0.00113118 | 0.095563 |
GOTERM_BP_FAT | Multicellular organismal metabolic process | 8 | 1.71 | 1.74E-04 | ACE, MMP-9, MMP-8, MMP-7, MMP-16, MMP-3, MMP-13, MMP-1 | 6.56 | 0.0030583 | 0.315166 |
GOTERM_BP_FAT | Collagen metabolic process | 7 | 1.50 | 2.49E-04 | MMP-9, MMP-8, MMP-7, MMP-16, MMP-3, MMP-13, MMP-1 | 7.58 | 0.00404851 | 0.451323 |
Annotation cluster 25 | Enrichment score: 5.36 | |||||||
GOTERM_BP_FAT | Hemopoiesis | 24 | 5.14 | 3.31E-06 | LYN, PLEK, EPAS1, MMP-9, PPARG, TP53, CDK6, RB1, KIT, KDR, ATP7A, HDAC4, CDC42, ACE, G6PD, BCL2, LCK, CASP8, ZAP70, ADAM17, BCL6, TRAF6, IL2, SYK | 3.08 | 1.21E-04 | 0.006014 |
GOTERM_BP_FAT | Immune system development | 26 | 5.57 | 4.69E-06 | MMP-9, UNG, PPARG, KIT, CDC42, ACE, BCL2, CASP8, ZAP70, BCL6, TRAF6, SYK, PLEK, LYN, EPAS1, TGFBR1, TP53, CDK6, RB1, KDR, ATP7A, HDAC4, G6PD, LCK, ADAM17, IL2 | 2.86 | 1.59E-04 | 0.00851 |
GOTERM_BP_FAT | Hemopoietic or lymphoid organ development | 25 | 5.35 | 5.23E-06 | MMP-9, PPARG, KIT, CDC42, ACE, BCL2, CASP8, ZAP70, BCL6, TRAF6, SYK, PLEK, LYN, EPAS1, TGFBR1, TP53, CDK6, RB1, KDR, ATP7A, HDAC4, G6PD, LCK, ADAM17, IL2 | 2.92 | 1.74E-04 | 0.009499 |
Annotation cluster 26 | Enrichment score: 5.32 | |||||||
GOTERM_BP_FAT | Programmed cell death | 44 | 9.42 | 2.08E-06 | TRAF2, PPARD, HRAS, XIAP, ADORA2A, GJA1, BCL2L1, SFN, KIT, PTEN, AKT1, TNFRSF1A, APP, CASP3, ECE1, CXCR4, TIAM1, PTK2B, CASP7, BCL2, RAC1, CASP8, TGM2, PAK1, TRAF6, CASP1, SGK1, ROCK1, GZMA, LGALS1, TP53, BIRC7, RAF1, GZMB, CDK5, BRCA1, PLG, NAE1, VCP, F2, LCK, MAPK8, MDM4, PDCD6IP | 2.18 | 7.88E-05 | 0.003772 |
GOTERM_BP_FAT | Cell death | 48 | 10.28 | 5.10E-06 | TRAF2, PPARD, HRAS, SPG7, XIAP, ADORA2A, GJA1, BCL2L1, SFN, KIT, HPRT1, PTEN, AKT1, TNFRSF1A, APP, CASP3, ECE1, CXCR4, TIAM1, PTK2B, CASP7, BCL2, RAC1, CASP8, TGM2, PAK1, TRAF6, CASP1, AR, SGK1, ROCK1, GZMA, LGALS1, TP53, BIRC7, RAF1, GZMB, CDK5, BRCA1, PLG, NAE1, VCP, LCK, F2, CTSD, MAPK8, MDM4, PDCD6IP | 2.02 | 1.71E-04 | 0.009255 |
GOTERM_BP_FAT | Death | 48 | 10.28 | 6.06E-06 | TRAF2, PPARD, HRAS, SPG7, XIAP, ADORA2A, GJA1, BCL2L1, SFN, KIT, HPRT1, PTEN, AKT1, TNFRSF1A, APP, CASP3, ECE1, CXCR4, TIAM1, PTK2B, CASP7, BCL2, RAC1, CASP8, TGM2, PAK1, TRAF6, CASP1, AR, SGK1, ROCK1, GZMA, LGALS1, TP53, BIRC7, RAF1, GZMB, CDK5, BRCA1, PLG, NAE1, VCP, LCK, F2, CTSD, MAPK8, MDM4, PDCD6IP | 2.01 | 1.95E-04 | 0.011004 |
GOTERM_BP_FAT | Apoptosis | 42 | 8.99 | 8.02E-06 | TRAF2, PPARD, HRAS, XIAP, ADORA2A, GJA1, BCL2L1, SFN, PTEN, AKT1, TNFRSF1A, APP, CASP3, ECE1, CXCR4, TIAM1, PTK2B, CASP7, BCL2, RAC1, CASP8, PAK1, CASP1, TRAF6, SGK1, ROCK1, GZMA, LGALS1, TP53, BIRC7, RAF1, GZMB, CDK5, BRCA1, PLG, NAE1, VCP, F2, LCK, MAPK8, MDM4, PDCD6IP | 2.12 | 2.46E-04 | 0.014551 |
Annotation cluster 27 | Enrichment score: 5.27 | |||||||
GOTERM_BP_FAT | Glucose metabolic process | 20 | 4.28 | 6.48E-07 | PDK1, RBP4, PPARD, ALDH5A1, PDK3, PDK4, FBP1, DLAT, PPP1CC, PPARGC1A, PDHB, PCK1, AKT1, PPP1CA, TPI1, G6PD, PYGL, MAPK14, GSK3B, PDHA1 | 3.96 | 2.75E-05 | 0.001176 |
GOTERM_BP_FAT | Hexose metabolic process | 21 | 4.50 | 5.31E-06 | PDK1, RBP4, PPARD, ALDH5A1, PDK3, PDK4, FBP1, DLAT, PPP1CC, PPARGC1A, PDHB, PCK1, AKT1, KHK, PPP1CA, TPI1, G6PD, PYGL, MAPK14, GSK3B, PDHA1 | 3.32 | 1.75E-04 | 0.009641 |
GOTERM_BP_FAT | Monosaccharide metabolic process | 21 | 4.50 | 4.51E-05 | PDK1, RBP4, PPARD, ALDH5A1, PDK3, PDK4, FBP1, DLAT, PPP1CC, PPARGC1A, PDHB, PCK1, AKT1, KHK, PPP1CA, TPI1, G6PD, PYGL, MAPK14, GSK3B, PDHA1 | 2.87 | 9.94E-04 | 0.081769 |
Annotation cluster 28 | Enrichment score: 4.77 | |||||||
UP_SEQ_FEATURE | Short sequence motif: TXY | 6 | 1.28 | 5.80E-06 | MAPK1, MAPK14, MAPK3, MAPK9, MAPK8, MAPK10 | 20.46 | 2.88E-04 | 0.009734 |
INTERPRO | MAP kinase, conserved site | 6 | 1.28 | 1.12E-05 | MAPK1, MAPK14, MAPK3, MAPK9, MAPK8, MAPK10 | 17.87 | 3.13E-04 | 0.017402 |
GOTERM_MF_FAT | MAP kinase activity | 6 | 1.28 | 7.48E-05 | MAPK1, MAPK14, MAPK3, MAPK9, MAPK8, MAPK10 | 12.36 | 0.00154179 | 0.11556 |
Annotation cluster 29 | Enrichment score: 4.76 | |||||||
GOTERM_BP_FAT | Blood coagulation | 15 | 3.21 | 5.98E-06 | PLAT, F11, F10, PLEK, ADORA2A, F8, F9, CD40, F7, PLG, LPA, SERPINE1, F2, SERPINC1, PLAU | 4.46 | 1.95E-04 | 0.01085 |
GOTERM_BP_FAT | Coagulation | 15 | 3.21 | 5.98E-06 | PLAT, F11, F10, PLEK, ADORA2A, F8, F9, CD40, F7, PLG, LPA, SERPINE1, F2, SERPINC1, PLAU | 4.46 | 1.95E-04 | 0.01085 |
GOTERM_BP_FAT | Hemostasis | 15 | 3.21 | 1.17E-05 | PLAT, F11, F10, PLEK, ADORA2A, F8, F9, CD40, F7, PLG, LPA, SERPINE1, F2, SERPINC1, PLAU | 4.21 | 3.47E-04 | 0.021303 |
GOTERM_BP_FAT | Regulation of body fluid levels | 15 | 3.21 | 2.26E-04 | PLAT, F11, F10, PLEK, ADORA2A, F8, F9, CD40, F7, PLG, LPA, SERPINE1, F2, SERPINC1, PLAU | 3.23 | 0.00375601 | 0.410281 |
Annotation cluster 30 | Enrichment score: 4.68 | |||||||
UP_SEQ_FEATURE | Region of interest: S-adenosyl-L-methionine binding | 9 | 1.93 | 1.55E-06 | EHMT1, PNMT, METTL1, SETD8, GAMT, COMT, GNMT, EHMT2, NNMT | 10.52 | 8.76E-05 | 0.002605 |
UP_SEQ_FEATURE | Binding site: S-adenosyl-L- methionine | 10 | 2.14 | 3.45E-06 | EHMT1, HNMT, PNMT, SETD8, GAMT, COMT, GNMT, EHMT2, TPMT, NNMT | 8.02 | 1.82E-04 | 0.005799 |
SP_PIR_KEYWORDS | S-Adenosyl-L-methionine | 12 | 2.57 | 4.03E-05 | EHMT1, HNMT, PNMT, METTL1, SETD8, GAMT, COMT, GNMT, EHMT2, AMD1, TPMT, NNMT | 4.80 | 3.49E-04 | 0.05845 |
SP_PIR_KEYWORDS | Methyltransferase | 12 | 2.57 | 8.74E-04 | TYMS, EHMT1, HNMT, PNMT, METTL1, SETD8, GAMT, COMT, GNMT, EHMT2, TPMT, NNMT | 3.39 | 0.00613378 | 1.260168 |
Annotation cluster 31 | Enrichment score: 4.64 | |||||||
GOTERM_BP_FAT | Regulation of carbohydrate metabolic process | 10 | 2.14 | 3.66E-06 | AKT1, HDAC4, PLEK, IGF1, NR3C1, INSR, PPARGC1A, NR1H4, ARNT, AKT2 | 7.78 | 1.31E-04 | 0.006647 |
GOTERM_BP_FAT | Regulation of cellular carbohydrate metabolic process | 9 | 1.93 | 2.64E-05 | AKT1, HDAC4, PLEK, IGF1, NR3C1, INSR, PPARGC1A, ARNT, AKT2 | 7.18 | 6.86E-04 | 0.047923 |
GOTERM_BP_FAT | Regulation of glucose metabolic process | 8 | 1.71 | 1.20E-04 | AKT1, HDAC4, IGF1, NR3C1, INSR, PPARGC1A, ARNT, AKT2 | 6.93 | 0.00225032 | 0.21798 |
Annotation cluster 32 | Enrichment score: 4.32 | |||||||
SP_PIR_KEYWORDS | Zinc | 98 | 20.99 | 2.10E-09 | THRA, THRB, S100A7, MMP-9, IDE, MMP-8, MMP-7, ADH1C, ADH1B, ADH1A, MMP-3, MMP-1, BTK, PGR, FNTB, HMHA1, APP, ASPA, RARB, CPA1, DDAH1, NQO2, RARG, ROCK1, BRAF, RXRA, UBR2, PPP1CC, PPP1CA, PYGO1, ADAMTS5, ADAMTS4, TRAF2, MME, NR1H2, VDR, ACE, ECE1, ALB, CDA, GLO1, TRAF6, NR1H4, NR1H3, CPA4, ITK, EHMT1, ESRRG, EHMT2, BRCA1, NR1I3, NR1I2, S100B, AIRE, HGS, PARP1, CPB2, PPARA, SPG7, PPARD, PPARG, ZCWPW1, MMP-20, KDM5A, PRKCA, AR, TP53, PRKCI, ESR1, MMP-16, ESR2, MMP-13, MMP-12, PRKCB, PRKCQ, FOLH1, NAALAD2, CA4, ADAM17, MDM2, PDE9A, MDM4, CA2, CA1, XIAP, CA13, ADH5, ADH7, EEA1, NR3C1, ADH4, PPP2CA, BCL6, L3MBTL2, BIRC7, SIRT5, RAF1, QPCT, LTA4H, KDM4A | 1.84 | 4.10E-08 | 3.04E-06 |
GOTERM_MF_FAT | Transition metal ion binding | 123 | 26.34 | 0.00201 | THRA, THRB, S100A7, MMP-9, IDE, MMP-8, ADH1C, MMP-7, ADH1B, ADH1A, MMP-3, MMP-1, BTK, PGR, FNTB, HMHA1, APP, ASPA, FNTA, MAT1A, CPA1, RARB, DDAH1, NQO2, RARG, ROCK1, BRAF, RXRA, PIM1, F8, UBR2, PPP1CC, POR, PPP1CA, PDE5A, PYGO1, ADAMTS5, ADAMTS4, XDH, TRAF2, MME, NR1H2, ARG1, VDR, ACE, ECE1, ALB, ARG2, PIR, CDA, GLO1, TRAF6, NR1H4, NR1H3, ITK, CPA4, EHMT1, TGFBR1, ESRRG, ACACB, EHMT2, BRCA1, GART, ATP7A, HDAC4, NR1I3, NR1I2, S100B, AIRE, HGS, PTPN1, PARP1, ABL1, CPB2, ABO, PPARA, PPARD, SPG7, METAP1, METAP2, PPARG, ZCWPW1, MMP-20, HIF1AN, PDE8A, KDM5A, PRKCA, AR, ESR1, PRKCI, TP53, MMP-16, ESR2, MMP-13, MMP-12, PRKCB, PRKCQ, FOLH1, NAALAD2, ADAM17, CA4, MDM2, PDE9A, CA2, MDM4, CA1, TPH1, XIAP, CA13, ADH5, EEA1, ADH7, NR3C1, ADH4, PPP2CA, BCL6, L3MBTL2, BIRC7, SIRT5, RAF1, PCK1, QPCT, FYN, LTA4H, KDM4A | 1.27 | 0.02584329 | 3.062766 |
GOTERM_MF_FAT | Zinc ion binding | 97 | 20.77 | 0.026629 | THRA, THRB, S100A7, MMP-9, IDE, MMP-8, MMP-7, ADH1C, ADH1B, ADH1A, MMP-3, MMP-1, BTK, PGR, FNTB, HMHA1, APP, ASPA, FNTA, RARB, CPA1, DDAH1, NQO2, RARG, ROCK1, BRAF, RXRA, UBR2, PDE5A, PYGO1, ADAMTS5, ADAMTS4, TRAF2, MME, NR1H2, VDR, ACE, ECE1, CDA, GLO1, TRAF6, NR1H4, NR1H3, CPA4, ITK, EHMT1, ESRRG, EHMT2, BRCA1, HDAC4, NR1I3, NR1I2, S100B, AIRE, HGS, PTPN1, PARP1, CPB2, PPARA, SPG7, PPARD, PPARG, ZCWPW1, MMP- 20, KDM5A, PRKCA, AR, TP53, PRKCI, ESR1, MMP-16, ESR2, MMP-13, MMP-12, PRKCB, PRKCQ, FOLH1, NAALAD2, CA4, ADAM17, MDM2, MDM4, CA2, CA1, XIAP, CA13, ADH5, ADH7, EEA1, NR3C1, ADH4, BCL6, L3MBTL2, BIRC7, SIRT5, RAF1, QPCT, LTA4H, KDM4A | 1.21 | 0.19883278 | 34.1204 |
Annotation cluster 33 | Enrichment score: 4.22 | |||||||
GOTERM_BP_FAT | Phenol metabolic process | 9 | 1.93 | 1.39E-05 | ATP7A, PNMT, EPAS1, SULT1B1, MAOA, SULT1A1, SULT1A2, COMT, HPRT1 | 7.80 | 3.95E-04 | 0.025154 |
GOTERM_BP_FAT | Diol metabolic process | 8 | 1.71 | 9.89E-05 | ATP7A, PNMT, EPAS1, MAOA, SULT1A1, SULT1A2, COMT, HPRT1 | 7.14 | 0.00196673 | 0.179443 |
GOTERM_BP_FAT | Catechol metabolic process | 8 | 1.71 | 9.89E-05 | ATP7A, PNMT, EPAS1, MAOA, SULT1A1, SULT1A2, COMT, HPRT1 | 7.14 | 0.00196673 | 0.179443 |
GOTERM_BP_FAT | Catecholamine metabolic process | 8 | 1.71 | 9.89E-05 | ATP7A, PNMT, EPAS1, MAOA, SULT1A1, SULT1A2, COMT, HPRT1 | 7.14 | 0.00196673 | 0.179443 |
Annotation cluster 34 | Enrichment score: 4.16 | |||||||
PIR_SUPERFAMILY | Alcohol sulfotransferase | 7 | 1.50 | 1.65E-06 | SULT2A1, SULT1B1, SULT1A1, SULT1A2, SULT1C2, SULT1E1, SULT1C3 | 15.14 | 1.82E-04 | 0.002238 |
UP_SEQ_FEATURE | Nucleotide phosphate- binding region: PAPS | 8 | 1.71 | 9.72E-06 | SULT2A1, SULT1B1, SULT1A1, SULT2B1, SULT1A2, SULT1C2, SULT1E1, SULT1C3 | 10.23 | 4.54E-04 | 0.016313 |
INTERPRO | Sulfotransferase | 8 | 1.71 | 1.86E-05 | SULT2A1, SULT1B1, SULT1A1, SULT2B1, SULT1A2, SULT1C2, SULT1E1, SULT1C3 | 9.23 | 4.90E-04 | 0.028912 |
GOTERM_MF_FAT | Sulfotransferase activity | 8 | 1.71 | 0.00138 | SULT2A1, SULT1B1, SULT1A1, SULT2B1, SULT1A2, SULT1C2, SULT1E1, SULT1C3 | 4.71 | 0.01896331 | 2.111955 |
GOTERM_MF_FAT | Transferase activity, transferring sulfur- containing groups | 8 | 1.71 | 0.0037 | SULT2A1, SULT1B1, SULT1A1, SULT2B1, SULT1A2, SULT1C2, SULT1E1, SULT1C3 | 3.98 | 0.04321176 | 5.571159 |
Annotation cluster 35 | Enrichment score: 4.11 | |||||||
GOTERM_BP_FAT | Protein complex assembly | 36 | 7.71 | 2.61E-05 | HSD17B10, TRAF2, HRAS, GRB2, IDE, GJA1, PEX5, FKBP1A, HPRT1, SRC, MIF, TNFRSF1A, IGF1R, PTK2, PTK2B, RAC1, CASP8, TGM2, CDA, GNMT, INSR, SYK, PPP2R1A, HSP90AA1, APCS, MAP2K1, BRAF, ALDH5A1, TP53, CD40, CDK5, PPARGC1A, NCK2, VCP, MDM2, MDM4 | 2.16 | 6.89E-04 | 0.047358 |
GOTERM_BP_FAT | Protein complex biogenesis | 36 | 7.71 | 2.61E-05 | HSD17B10, TRAF2, HRAS, GRB2, IDE, GJA1, PEX5, FKBP1A, HPRT1, SRC, MIF, TNFRSF1A, IGF1R, PTK2, PTK2B, RAC1, CASP8, TGM2, CDA, GNMT, INSR, SYK, PPP2R1A, HSP90AA1, APCS, MAP2K1, BRAF, ALDH5A1, TP53, CD40, CDK5, PPARGC1A, NCK2, VCP, MDM2, MDM4 | 2.16 | 6.89E-04 | 0.047358 |
GOTERM_BP_FAT | Macromolecular complex assembly | 41 | 8.78 | 1.65E-04 | NCBP2, HSD17B10, TRAF2, NCBP1, HRAS, GRB2, IDE, GJA1, PEX5, FKBP1A, HPRT1, SRC, MIF, IGF1R, TNFRSF1A, PTK2, HIST1H4A, PTK2B, RAC1, CASP8, TGM2, CDA, GNMT, INSR, SYK, PPP2R1A, HSP90AA1, APCS, MAP2K1, BRAF, ALDH5A1, SNUPN, TP53, CD40, CDK5, PPARGC1A, NCK2, VCP, HIST1H3A, MDM2, MDM4, HIST1H3G | 1.87 | 0.00291459 | 0.298718 |
GOTERM_BP_FAT | Macromolecular complex subunit organization | 42 | 9.00 | 3.20E-04 | NCBP2, HSD17B10, NCBP1, TRAF2, HRAS, GRB2, IDE, GJA1, PEX5, FKBP1A, HPRT1, SRC, MIF, IGF1R, TNFRSF1A, PTK2, HIST1H4A, PTK2B, RAC1, CASP8, TGM2, CDA, GNMT, INSR, SYK, PPP2R1A, HSP90AA1, APCS, MAP2K1, BRAF, ALDH5A1, SNUPN, TP53, CD40, CDK5, PPARGC1A, NCK2, VCP, HIST1H3A, PLA2G2A, MDM2, MDM4, HIST1H3G | 1.79 | 0.0048243 | 0.578406 |
Annotation cluster 36 | Enrichment score: 4.00 | |||||||
GOTERM_BP_FAT | Regulation of cell activation | 18 | 3.85 | 6.55E-05 | TRAF2, PLEK, ADORA2A, ERBB2, CD40, PNP, MIF, CD38, PRKCQ, NCK2, CASP3, LCK, SFTPD, ZAP70, BCL6, TRAF6, SYK, IL2 | 3.12 | 0.00136967 | 0.118797 |
GOTERM_BP_FAT | Regulation of lymphocyte activation | 16 | 3.43 | 1.08E-04 | TRAF2, ADORA2A, ERBB2, CD40, PNP, PRKCQ, NCK2, CD38, CASP3, LCK, SFTPD, ZAP70, BCL6, TRAF6, SYK, IL2 | 3.28 | 0.00208753 | 0.196338 |
GOTERM_BP_FAT | Regulation of leukocyte activation | 17 | 3.64 | 1.17E-04 | TRAF2, ADORA2A, ERBB2, CD40, PNP, MIF, PRKCQ, NCK2, CD38, CASP3, LCK, SFTPD, ZAP70, BCL6, TRAF6, SYK, IL2 | 3.11 | 0.00220533 | 0.212381 |
GOTERM_BP_FAT | Regulation of T-cell activation | 14 | 3.00 | 1.22E-04 | TRAF2, ADORA2A, ERBB2, PNP, PRKCQ, NCK2, CASP3, LCK, SFTPD, ZAP70, BCL6, TRAF6, SYK, IL2 | 3.63 | 0.0022739 | 0.221543 |
Annotation cluster 37 | Enrichment score: 3.97 | |||||||
GOTERM_BP_FAT | Positive regulation of phosphorylation | 13 | 2.78 | 7.83E-05 | EGFR, PRKCA, LYN, TGFBR1, IGF1, TTK, BCL2, F2, ADAM17, TNK2, INSR, SYK, IL2 | 4.07 | 0.00161717 | 0.142086 |
GOTERM_BP_FAT | Positive regulation of phosphate metabolic process | 13 | 2.78 | 1.06E-04 | EGFR, PRKCA, LYN, TGFBR1, IGF1, TTK, BCL2, F2, ADAM17, TNK2, INSR, SYK, IL2 | 3.94 | 0.00206093 | 0.191517 |
GOTERM_BP_FAT | Positive regulation of phosphorus metabolic process | 13 | 2.78 | 1.06E-04 | EGFR, PRKCA, LYN, TGFBR1, IGF1, TTK, BCL2, F2, ADAM17, TNK2, INSR, SYK, IL2 | 3.94 | 0.00206093 | 0.191517 |
GOTERM_BP_FAT | Positive regulation of protein amino acid phosphorylation | 12 | 2.57 | 1.56E-04 | PRKCA, LYN, BCL2, TGFBR1, F2, ADAM17, IGF1, TTK, TNK2, INSR, IL2, SYK | 4.09 | 0.00277529 | 0.282881 |
Annotation cluster 38 | Enrichment score: 3.85 | |||||||
GOTERM_BP_FAT | Regulation of establishment of protein localization | 15 | 3.21 | 4.31E-05 | RBP4, ADORA2A, TGFBR1, PRKCI, CD40, CDK5, PTPN11, AKT1, PRKCQ, PDPK1, GSK3B, PRKACA, TRAF6, CASP1, IL2 | 3.76 | 9.64E-04 | 0.078194 |
GOTERM_BP_FAT | Regulation of protein localization | 16 | 3.43 | 4.84E-05 | RBP4, ADORA2A, TGFBR1, PRKCI, CD40, CDK5, PTPN11, AKT1, PRKCQ, PDPK1, GSK3B, BCL2, PRKACA, TRAF6, CASP1, IL2 | 3.52 | 0.00105367 | 0.087828 |
GOTERM_BP_FAT | Regulation of protein transport | 12 | 2.57 | 0.00132 | PRKCQ, RBP4, ADORA2A, GSK3B, TGFBR1, PRKACA, CD40, TRAF6, CASP1, CDK5, IL2, PTPN11 | 3.19 | 0.0157027 | 2.369144 |
Annotation cluster 39 | Enrichment score: 3.73 | |||||||
INTERPRO | EGF receptor, L domain | 5 | 1.07 | 1.96E-05 | EGFR, IGF1R, ERBB4, ERBB2, INSR | 25.53 | 5.03E-04 | 0.030568 |
INTERPRO | Furin-like cysteine-rich region | 5 | 1.07 | 1.96E-05 | EGFR, IGF1R, ERBB4, ERBB2, INSR | 25.53 | 5.03E-04 | 0.030568 |
INTERPRO | Furin-like repeat | 5 | 1.07 | 0.001343 | EGFR, IGF1R, ERBB4, ERBB2, INSR | 9.93 | 0.02767984 | 2.072751 |
SMART | FU | 5 | 1.07 | 0.002245 | EGFR, IGF1R, ERBB4, ERBB2, INSR | 8.61 | 0.03373603 | 2.698772 |
Annotation cluster 40 | Enrichment score: 3.73 | |||||||
GOTERM_BP_FAT | Cell projection organization | 30 | 6.42 | 1.26E-05 | FGFR1, CDK5R1, NRP1, ADORA2A, ERBB2, GJA1, HPRT1, PTEN, AKT1, CDC42, IGF1R, APP, PTK2, CXCR4, PTK2B, BCL2, RAC1, CDH23, EGFR, PRKCA, MAP2K1, ROCK1, PLEK, RXRA, CDK5, PTPN11, ATP7A, NCK2, S100B, SDCBP | 2.47 | 3.66E-04 | 0.022889 |
GOTERM_BP_FAT | Neuron projection development | 23 | 4.93 | 3.91E-05 | PRKCA, EGFR, FGFR1, CDK5R1, NRP1, MAP2K1, ADORA2A, RXRA, ERBB2, GJA1, HPRT1, CDK5, PTEN, PTPN11, ATP7A, IGF1R, PTK2, APP, S100B, CXCR4, PTK2B, BCL2, RAC1 | 2.73 | 9.07E-04 | 0.070998 |
GOTERM_BP_FAT | Neuron projection morphogenesis | 20 | 4.28 | 7.95E-05 | PRKCA, EGFR, CDK5R1, NRP1, MAP2K1, ADORA2A, RXRA, ERBB2, GJA1, HPRT1, CDK5, PTPN11, ATP7A, IGF1R, PTK2, APP, S100B, CXCR4, BCL2, RAC1 | 2.85 | 0.00163049 | 0.144174 |
GOTERM_BP_FAT | Neuron development | 26 | 5.57 | 1.45E-04 | FGFR1, CDK5R1, NRP1, ADORA2A, ERBB2, GJA1, HPRT1, PTEN, IGF1R, APP, PTK2, PTK2B, CXCR4, BCL2, RAC1, CDH23, EGFR, PRKCA, RET, MAP2K1, RXRA, PRKCI, CDK5, PTPN11, ATP7A, S100B | 2.33 | 0.00262906 | 0.26354 |
GOTERM_BP_FAT | Neuron differentiation | 30 | 6.42 | 2.81E-04 | FGFR1, CDK5R1, NRP1, ADORA2A, ERBB2, GJA1, PEX5, HPRT1, PTEN, CDC42, IGF1R, APP, PTK2, CXCR4, PTK2B, BCL2, RAC1, CDH23, EGFR, PRKCA, RET, MAP2K1, RXRA, TGFBR1, PRKCI, CDK5, PTPN11, ATP7A, PRKCQ, S100B | 2.08 | 0.00445775 | 0.50945 |
GOTERM_BP_FAT | Cell morphogenesis | 26 | 5.57 | 3.08E-04 | CDK5R1, NRP1, ADORA2A, ERBB2, GJA1, HPRT1, IGF1R, CDC42, APP, PTK2, CXCR4, BCL2, RAC1, BCL6, DLG1, CDH23, EGFR, PRKCA, MAP2K1, RXRA, PRKCI, CDK5, PTPN11, ATP7A, S100B, ERBB2IP | 2.22 | 0.00471944 | 0.557892 |
GOTERM_BP_FAT | Cell projection morphogenesis | 20 | 4.28 | 4.83E-04 | PRKCA, EGFR, CDK5R1, NRP1, MAP2K1, ADORA2A, RXRA, ERBB2, GJA1, HPRT1, CDK5, PTPN11, ATP7A, IGF1R, PTK2, APP, S100B, CXCR4, BCL2, RAC1 | 2.48 | 0.00684232 | 0.873863 |
GOTERM_BP_FAT | Cell part morphogenesis | 20 | 4.28 | 8.26E-04 | PRKCA, EGFR, CDK5R1, NRP1, MAP2K1, ADORA2A, RXRA, ERBB2, GJA1, HPRT1, CDK5, PTPN11, ATP7A, IGF1R, PTK2, APP, S100B, CXCR4, BCL2, RAC1 | 2.37 | 0.01076448 | 1.488171 |
GOTERM_BP_FAT | Cellular component morphogenesis | 26 | 5.57 | 0.001471 | CDK5R1, NRP1, ADORA2A, ERBB2, GJA1, HPRT1, IGF1R, CDC42, APP, PTK2, CXCR4, BCL2, RAC1, BCL6, DLG1, CDH23, EGFR, PRKCA, MAP2K1, RXRA, PRKCI, CDK5, PTPN11, ATP7A, S100B, ERBB2IP | 1.99 | 0.01716579 | 2.636383 |
Annotation cluster 41 | Enrichment score: 3.64 | |||||||
GOTERM_CC_FAT | Membrane-enclosed lumen | 83 | 17.77 | 9.64E-05 | NCBP2, NCBP1, TSG101, IDE, PEX5, XRCC1, AGXT, C1QC, PDHB, AKT1, KDM1A, PARN, APP, CASP3, CSNK2A1, CASP7, CASP8, PDHA1, BRD4, CFD, KDM5A, RARG, LYN, GATM, TP53, F8, TLE1, RB1, PPP1CC, PPARGC1A, WEE1, CDK2, MAPK1, PNKP, PPP1CA, MAPK3, MDM2, MAPK8, ME2, NEK2, FARS2, CHEK1, KIT, NR3C1, CHEK2, HIST1H4A, BCHE, ALB, MDC1, GSTK1, NUDT21, HSD17B4, PDK1, BCKDHA, DHX9, KAT2B, CES1, EPAS1, PDK3, PDK4, BCKDHB, IGF1, SIRT5, DLAT, NXF1, BRCA1, PCK1, HDAC4, DUSP3, HDAC2, RPS6KA1, VCP, PLK1, MAPK14, DYRK1A, ALDH2, KDM4A, ABL1, PARP1, PARP2, HDAC8, HDAC7, UBE2E1 | 1.50 | 0.00321839 | 0.13268 |
GOTERM_CC_FAT | Organelle lumen | 81 | 17.34 | 1.45E-04 | NCBP2, NCBP1, TSG101, IDE, PEX5, XRCC1, AGXT, C1QC, PDHB, AKT1, KDM1A, PARN, APP, CASP3, CSNK2A1, CASP7, CASP8, PDHA1, BRD4, CFD, KDM5A, RARG, TP53, F8, TLE1, RB1, PPP1CC, PPARGC1A, WEE1, CDK2, MAPK1, PNKP, PPP1CA, MAPK3, MDM2, MAPK8, ME2, NEK2, FARS2, CHEK1, KIT, NR3C1, CHEK2, HIST1H4A, BCHE, ALB, MDC1, GSTK1, NUDT21, HSD17B4, PDK1, BCKDHA, DHX9, KAT2B, CES1, EPAS1, PDK3, PDK4, BCKDHB, IGF1, SIRT5, DLAT, NXF1, BRCA1, PCK1, HDAC4, DUSP3, HDAC2, RPS6KA1, VCP, PLK1, MAPK14, DYRK1A, ALDH2, KDM4A, ABL1, PARP1, PARP2, HDAC8, HDAC7, UBE2E1 | 1.50 | 0.00410352 | 0.199949 |
GOTERM_CC_FAT | Intracellular organelle lumen | 76 | 16.27 | 8.68E-04 | NCBP2, NCBP1, TSG101, IDE, PEX5, XRCC1, AGXT, C1QC, PDHB, AKT1, KDM1A, PARN, CASP3, CSNK2A1, CASP7, CASP8, PDHA1, BRD4, KDM5A, RARG, TP53, TLE1, RB1, PPP1CC, PPARGC1A, WEE1, CDK2, MAPK1, PNKP, PPP1CA, MAPK3, MDM2, MAPK8, ME2, NEK2, FARS2, CHEK1, NR3C1, KIT, CHEK2, HIST1H4A, BCHE, MDC1, GSTK1, NUDT21, HSD17B4, PDK1, BCKDHA, DHX9, KAT2B, CES1, EPAS1, PDK3, PDK4, BCKDHB, SIRT5, DLAT, NXF1, BRCA1, PCK1, HDAC4, DUSP3, HDAC2, RPS6KA1, VCP, PLK1, MAPK14, DYRK1A, ALDH2, KDM4A, ABL1, PARP1, PARP2, HDAC8, HDAC7, UBE2E1 | 1.44 | 0.01759311 | 1.189132 |
Annotation cluster 42 | Enrichment score: 3.60 | |||||||
GOTERM_BP_FAT | Negative regulation of macromolecule biosynthetic process | 36 | 7.71 | 1.32E-04 | PPARA, PPARD, THRA, THRB, TSG101, PPARG, NR1H2, KDM1A, VDR, FNTA, EED, SFTPD, BCL6, RARB, NR1H4, PRKCA, RARG, EHMT1, RXRA, ELANE, TP53, SIRT5, TLE1, RB1, BRCA1, HDAC4, NR1I2, NCOA2, HDAC2, BACE2, UBA3, MDM2, FABP4, SETD8, MDM4, HDAC8 | 2.00 | 0.00243752 | 0.238856 |
GOTERM_BP_FAT | Negative regulation of gene expression | 34 | 7.28 | 1.33E-04 | PPARA, PPARD, THRA, THRB, TSG101, PPARG, BCL2L1, NR1H2, KDM1A, VDR, SND1, EED, BCL6, RARB, INSR, NR1H4, RARG, EHMT1, RXRA, TP53, SIRT5, TLE1, RB1, BRCA1, HDAC4, NCOA2, HDAC2, NR1I2, UBA3, MDM2, FABP4, SETD8, MDM4, HDAC8 | 2.05 | 0.00244468 | 0.240933 |
GOTERM_BP_FAT | Negative regulation of biosynthetic process | 37 | 7.92 | 1.53E-04 | PPARA, PPARD, THRA, THRB, TSG101, PPARG, NR1H2, KDM1A, VDR, FNTA, EED, SFTPD, BCL6, RARB, NR1H4, PRKCA, RARG, EHMT1, PLEK, RXRA, ELANE, TP53, SIRT5, TLE1, RB1, BRCA1, HDAC4, NR1I2, NCOA2, HDAC2, BACE2, UBA3, MDM2, FABP4, SETD8, MDM4, HDAC8 | 1.96 | 0.00272817 | 0.276544 |
GOTERM_BP_FAT | Negative regulation of cellular biosynthetic process | 36 | 7.71 | 2.14E-04 | PPARA, PPARD, THRA, THRB, TSG101, PPARG, NR1H2, KDM1A, VDR, EED, SFTPD, BCL6, RARB, NR1H4, PRKCA, RARG, EHMT1, PLEK, RXRA, ELANE, TP53, SIRT5, TLE1, RB1, BRCA1, HDAC4, NR1I2, NCOA2, HDAC2, BACE2, UBA3, MDM2, FABP4, SETD8, MDM4, HDAC8 | 1.95 | 0.00359443 | 0.388594 |
GOTERM_BP_FAT | Negative regulation of transcription | 31 | 6.64 | 2.76E-04 | PPARA, PPARD, THRA, THRB, TSG101, PPARG, NR1H2, KDM1A, VDR, EED, BCL6, RARB, NR1H4, RARG, EHMT1, RXRA, TP53, SIRT5, TLE1, RB1, BRCA1, HDAC4, NCOA2, HDAC2, NR1I2, UBA3, MDM2, FABP4, SETD8, MDM4, HDAC8 | 2.05 | 0.00440251 | 0.500666 |
GOTERM_BP_FAT | Negative regulation of nitrogen compound metabolic process | 33 | 7.07 | 4.87E-04 | PPARA, PPARD, THRA, THRB, TSG101, PPARG, COMT, NR1H2, VDR, KDM1A, EED, CDA, BCL6, RARB, NR1H4, RARG, EHMT1, RXRA, TP53, SIRT5, TLE1, RB1, BRCA1, HDAC4, NCOA2, HDAC2, NR1I2, UBA3, MDM2, FABP4, SETD8, MDM4, HDAC8 | 1.93 | 0.00683604 | 0.88072 |
GOTERM_BP_FAT | Negative regulation of nucleobase, nucleoside, nucleotide, and nucleic acid metabolic process | 32 | 6.85 | 8.13E-04 | PPARA, PPARD, THRA, THRB, TSG101, PPARG, NR1H2, KDM1A, VDR, EED, CDA, BCL6, RARB, NR1H4, RARG, EHMT1, RXRA, TP53, SIRT5, TLE1, RB1, BRCA1, HDAC4, NCOA2, HDAC2, NR1I2, UBA3, MDM2, FABP4, SETD8, MDM4, HDAC8 | 1.90 | 0.0106896 | 1.465914 |
Annotation cluster 43 | Enrichment score: 3.59 | |||||||
GOTERM_BP_FAT | Positive regulation of nucleobase, nucleoside, nucleotide, and nucleic acid metabolic process | 42 | 8.99 | 1.87E-05 | NCBP1, PPARA, HRAS, THRA, THRB, ADORA2A, PPARG, ARNT, NR1H2, IGF1R, TNFRSF1A, APP, RARB, KDM5A, INSR, NR1H4, NR1H3, BCKDHA, AR, RARG, MAP2K1, EPAS1, TGFBR1, RXRA, ESRRG, TP53, IGF1, RB1, ESR2, CD40, PPARGC1A, BRCA1, CDK2, TNKS2, HDAC4, MAPK1, NCOA1, NCOA2, HDAC2, MAPK14, JAK3, IL2 | 2.04 | 5.12E-04 | 0.034005 |
GOTERM_BP_FAT | Positive regulation of gene expression | 37 | 7.92 | 1.99E-04 | PPARA, THRA, THRB, PPARG, KIT, ARNT, NR1H2, TNFRSF1A, APP, RARB, KDM5A, NR1H4, NR1H3, BCKDHA, AR, RARG, EPAS1, TGFBR1, RXRA, ESRRG, TP53, ESR1, IGF1, RB1, ESR2, PPARGC1A, BRCA1, CDK2, HDAC4, MAPK1, NCOA1, NCOA2, HDAC2, MAPK14, MAPK9, JAK3, IL2 | 1.93 | 0.00342307 | 0.360451 |
GOTERM_BP_FAT | Positive regulation of transcription from RNA polymerase II promoter | 27 | 5.78 | 2.41E-04 | PPARA, THRA, THRB, PPARG, ARNT, NR1H2, TNFRSF1A, APP, RARB, NR1H4, NR1H3, AR, RARG, EPAS1, RXRA, TP53, IGF1, RB1, ESR2, PPARGC1A, HDAC4, NCOA1, NCOA2, HDAC2, MAPK14, JAK3, IL2 | 2.21 | 0.00396061 | 0.437076 |
GOTERM_BP_FAT | Positive regulation of RNA metabolic process | 32 | 6.85 | 2.87E-04 | PPARA, NCBP1, THRA, THRB, PPARG, ARNT, NR1H2, TNFRSF1A, APP, RARB, NR1H4, NR1H3, BCKDHA, AR, RARG, MAP2K1, EPAS1, RXRA, ESRRG, TP53, IGF1, RB1, ESR2, PPARGC1A, BRCA1, HDAC4, NCOA1, NCOA2, HDAC2, MAPK14, JAK3, IL2 | 2.02 | 0.00447801 | 0.519307 |
GOTERM_BP_FAT | Positive regulation of transcription | 34 | 7.28 | 9.92E-04 | PPARA, THRA, THRB, PPARG, ARNT, NR1H2, TNFRSF1A, APP, RARB, KDM5A, NR1H4, NR1H3, BCKDHA, AR, RARG, EPAS1, RXRA, TGFBR1, ESRRG, TP53, IGF1, RB1, ESR2, PPARGC1A, BRCA1, CDK2, HDAC4, MAPK1, NCOA1, NCOA2, HDAC2, MAPK14, JAK3, IL2 | 1.83 | 0.01261501 | 1.785517 |
GOTERM_BP_FAT | Positive regulation of transcription, DNA dependent | 30 | 6.42 | 0.001113 | PPARA, THRA, THRB, PPARG, ARNT, NR1H2, TNFRSF1A, APP, RARB, NR1H4, NR1H3, BCKDHA, AR, RARG, EPAS1, RXRA, ESRRG, TP53, IGF1, RB1, ESR2, PPARGC1A, BRCA1, HDAC4, NCOA1, NCOA2, HDAC2, MAPK14, JAK3, IL2 | 1.91 | 0.0137637 | 2.001185 |
Annotation cluster 44 | Enrichment score: 3.57 | |||||||
GOTERM_BP_FAT | Regulation of glucose metabolic process | 8 | 1.71 | 1.20E-04 | AKT1, HDAC4, IGF1, NR3C1, INSR, PPARGC1A, ARNT, AKT2 | 6.93 | 0.00225032 | 0.21798 |
GOTERM_BP_FAT | Positive regulation of glucose metabolic process | 6 | 1.28 | 2.99E-04 | AKT1, IGF1, INSR, PPARGC1A, ARNT, AKT2 | 9.58 | 0.00461973 | 0.540924 |
GOTERM_BP_FAT | Positive regulation of cellular carbohydrate metabolic process | 6 | 1.28 | 3.88E-04 | AKT1, IGF1, INSR, PPARGC1A, ARNT, AKT2 | 9.10 | 0.00566472 | 0.70135 |
GOTERM_BP_FAT | Positive regulation of carbohydrate metabolic process | 6 | 1.28 | 3.88E-04 | AKT1, IGF1, INSR, PPARGC1A, ARNT, AKT2 | 9.10 | 0.00566472 | 0.70135 |
Annotation cluster 45 | Enrichment score: 3.49 | |||||||
GOTERM_BP_FAT | Positive regulation of cyclin-dependent prote in kinase activity during G1/S | 4 | 0.86 | 1.38E-04 | EGFR, AKT1, PIM1, ADAM17 | 30.33 | 0.00252379 | 0.25015 |
GOTERM_BP_FAT | Regulation of cyclin- dependent protein kinase activity during G1/S | 4 | 0.86 | 1.38E-04 | EGFR, AKT1, PIM1, ADAM17 | 30.33 | 0.00252379 | 0.25015 |
GOTERM_BP_FAT | Positive regulation of cyclin-dependent protein kinase activity | 4 | 0.86 | 0.00175 | EGFR, AKT1, PIM1, ADAM17 | 15.17 | 0.01988844 | 3.129 |
Annotation cluster 46 | Enrichment score: 3.44 | |||||||
GOTERM_BP_FAT | Regulation of lymphocyte proliferation | 12 | 2.57 | 8.23E-05 | CD38, PRKCQ, NCK2, CASP3, ERBB2, ZAP70, SFTPD, BCL6, CD40, PNP, IL2, SYK | 4.39 | 0.00166731 | 0.149307 |
GOTERM_BP_FAT | Regulation of mononuclear cell proliferation | 12 | 2.57 | 9.20E-05 | CD38, PRKCQ, NCK2, CASP3, ERBB2, ZAP70, SFTPD, BCL6, CD40, PNP, IL2, SYK | 4.33 | 0.00183952 | 0.1668 |
GOTERM_BP_FAT | Regulation of leukocyte proliferation | 12 | 2.57 | 9.20E-05 | CD38, PRKCQ, NCK2, CASP3, ERBB2, ZAP70, SFTPD, BCL6, CD40, PNP, IL2, SYK | 4.33 | 0.00183952 | 0.1668 |
GOTERM_BP_FAT | Positive regulation of cell activation | 13 | 2.78 | 2.86E-04 | TRAF2, PLEK, CD40, PNP, PRKCQ, NCK2, CD38, LCK, ZAP70, BCL6, TRAF6, SYK, IL2 | 3.55 | 0.00449264 | 0.518482 |
GOTERM_BP_FAT | Positive regulation of lymphocyte activation | 12 | 2.57 | 3.36E-04 | TRAF2, CD38, PRKCQ, NCK2, LCK, ZAP70, BCL6, CD40, TRAF6, PNP, IL2, SYK | 3.75 | 0.00504753 | 0.607989 |
GOTERM_BP_FAT | Positive regulation of lymphocyte proliferation | 9 | 1.93 | 4.03E-04 | CD38, PRKCQ, NCK2, ZAP70, BCL6, CD40, PNP, IL2, SYK | 4.96 | 0.0058375 | 0.729273 |
GOTERM_BP_FAT | Positive regulation of mononuclear cell proliferation | 9 | 1.93 | 4.57E-04 | CD38, PRKCQ, NCK2, ZAP70, BCL6, CD40, PNP, IL2, SYK | 4.87 | 0.00655668 | 0.826394 |
GOTERM_BP_FAT | Positive regulation of leukocyte proliferation | 9 | 1.93 | 4.57E-04 | CD38, PRKCQ, NCK2, ZAP70, BCL6, CD40, PNP, IL2, SYK | 4.87 | 0.00655668 | 0.826394 |
GOTERM_BP_FAT | Positive regulation of leukocyte activation | 12 | 2.57 | 7.21E-04 | TRAF2, CD38, PRKCQ, NCK2, LCK, ZAP70, BCL6, CD40, TRAF6, PNP, IL2, SYK | 3.43 | 0.00971853 | 1.300425 |
GOTERM_BP_FAT | Regulation of T-cell proliferation | 9 | 1.93 | 9.16E-04 | PRKCQ, NCK2, CASP3, ERBB2, ZAP70, SFTPD, PNP, IL2, SYK | 4.40 | 0.01184284 | 1.650107 |
GOTERM_BP_FAT | Positive regulation of T-cell activation | 9 | 1.93 | 0.003429 | TRAF2, PRKCQ, NCK2, LCK, ZAP70, TRAF6, PNP, IL2, SYK | 3.59 | 0.03453311 | 6.043888 |
Annotation cluster 47 | Enrichment score: 3.30 | |||||||
GOTERM_BP_FAT | Negative regulation of transferase activity | 12 | 2.57 | 3.07E-04 | PRKCA, AKT1, PPP2R1A, PDPK1, CASP3, HMGCR, ADORA2A, PPP2CA, PPARG, FABP4, RB1, SFN | 3.79 | 0.00471957 | 0.555258 |
GOTERM_BP_FAT | Negative regulation of protein kinase activity | 11 | 2.36 | 5.57E-04 | PRKCA, AKT1, PPP2R1A, PDPK1, CASP3, HMGCR, ADORA2A, PPP2CA, FABP4, RB1, SFN | 3.84 | 0.00764671 | 1.006445 |
GOTERM_BP_FAT | Negative regulation of kinase activity | 11 | 2.36 | 7.30E-04 | PRKCA, AKT1, PPP2R1A, PDPK1, CASP3, HMGCR, ADORA2A, PPP2CA, FABP4, RB1, SFN | 3.71 | 0.00979929 | 1.316686 |
Annotation cluster 48 | Enrichment score: 3.14 | |||||||
SP_PIR_KEYWORDS | SH3 domain | 16 | 3.43 | 1.94E-04 | ITK, LYN, GRB2, HCK, NCF4, SRC, BTK, NCK2, TJP1, FYN, MAP3K9, LCK, TNK2, ABL1, ARHGAP9, DLG1 | 3.14 | 0.0015486 | 0.280714 |
UP_SEQ_FEATURE | SH3 domain | 14 | 3.00 | 4.16E-04 | ITK, LYN, HCK, NCF4, SRC, BTK, TJP1, FYN, MAP3K9, LCK, TNK2, ABL1, ARHGAP9, DLG1 | 3.24 | 0.0157035 | 0.695681 |
INTERPRO | Src homology-3 domain | 16 | 3.43 | 9.74E-04 | ITK, LYN, GRB2, HCK, NCF4, SRC, BTK, NCK2, TJP1, FYN, MAP3K9, LCK, TNK2, ABL1, ARHGAP9, DLG1 | 2.69 | 0.0206159 | 1.506777 |
SMART | SH3 domain | 16 | 3.43 | 0.003617 | ITK, LYN, GRB2, HCK, NCF4, SRC, BTK, NCK2, TJP1, FYN, MAP3K9, LCK, TNK2, ABL1, ARHGAP9, DLG1 | 2.33 | 0.04574947 | 4.316077 |
Annotation cluster 49 | Enrichment score: 3.06 | |||||||
GOTERM_BP_FAT | Mononuclear cell proliferation | 8 | 1.71 | 5.31E-04 | ACE, CXCR4, FYN, BCL2, TP53, FKBP1A, CD40, HPRT1 | 5.51 | 0.00731779 | 0.959108 |
GOTERM_BP_FAT | Leukocyte proliferation | 8 | 1.71 | 5.31E-04 | ACE, CXCR4, FYN, BCL2, TP53, FKBP1A, CD40, HPRT1 | 5.51 | 0.00731779 | 0.959108 |
GOTERM_BP_FAT | Lymphocyte proliferation | 7 | 1.50 | 0.002353 | CXCR4, FYN, BCL2, TP53, FKBP1A, CD40, HPRT1 | 5.06 | 0.02523826 | 4.185354 |
Abbreviations: DAVID, Database for Annotation, Visualization, and Integrated Discovery; UA, ursolic acid; FDR, false discovery rate.