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. 2015 Jul 31;9:3989–4104. doi: 10.2147/DDDT.S85426

Table 3.

The top enriched clusters (enrichment score >3) by the DAVID database for the target list of UA derived from molecular docking calculations

Category Term Count % P-value Genes Fold enrichment Benjamini FDR
Annotation cluster 1 Enrichment score: 31.55
UP_SEQ_FEATURE ATP binding site 85 18.20 1.71E-43 SPG7, TTK, AURKA, BTK, CSNK2A2, AKT1, PDPK1, CSNK2A1, MAT1A, MAP3K9, PAK4, PRKACA, PAK1, INSR, AKT2, SYK, PRKCA, EGFR, RET, SGK1, LYN, BRAF, ROCK1, PIM1, PRKCI, CDK6, ALK, CDK5, WEE1, CDK2, PRKCB, TYK2, MAPK1, PRKCQ, NME2, NME1, MAPK3, LCK, MAPK9, MAPK8, FGFR2, CHKA, FGFR1, ERBB4, NEK2, CHKB, ERBB2, MAPKAPK3, ADRBK1, CHEK1, MAPKAPK2, KIT, CHEK2, EPHB4, SRC, IRAK4, IGF1R, PTK2, PTK2B, TEK, ZAP70, CSF1R, PDK1, ITK, MAP2K1, HCK, PDK3, TGFBR1, PDK4, MET, RAF1, MAPK10, KDR, KHK, RPS6KA1, PLK1, FYN, MAPK14, GSK3B, DYRK1A, GRK6, JAK1, JAK3, TNK2, MERTK, ABL1 6.42 9.33E-41 2.87E-40
SP_PIR_KEYWORDS Kinase 89 19.06 5.29E-39 TTK, AURKA, BTK, CSNK2A2, AKT1, PDPK1, CSNK2A1, MAP3K9, PAK4, PRKACA, PAK1, INSR, AKT2, SYK, PIK3CG, PRKCA, EGFR, RET, SGK1, LYN, BRAF, ROCK1, PIM1, PRKCI, CDK6, ALK, CDK5, WEE1, CDK2, PRKCB, TYK2, MAPK1, PRKCQ, PNKP, NME2, NME1, ADK, MAPK3, LCK, MAPK9, MAPK8, FGFR2, FGFR1, CHKA, CDK5R1, ERBB4, NEK2, CHKB, ERBB2, DCK, MAPKAPK3, ADRBK1, CHEK1, MAPKAPK2, KIT, CHEK2, EPHB4, SRC, IRAK4, IGF1R, PTK2, PTK2B, TEK, ZAP70, CSF1R, PDK1, ITK, MAP2K1, HCK, PDK3, TGFBR1, PDK4, MET, RAF1, MAPK10, KDR, KHK, RPS6KA1, PLK1, FYN, MAPK14, GSK3B, DYRK1A, GRK6, JAK1, JAK3, TNK2, MERTK, ABL1, PLAU 5.33 1.40E-36 7.68E-36
INTERPRO Protein kinase, ATP binding site 77 16.49 1.08E-37 TTK, AURKA, BTK, CSNK2A2, AKT1, PDPK1, CSNK2A1, MAP3K9, PAK4, PRKACA, PAK1, INSR, AKT2, SYK, PRKCA, EGFR, SGK1, RET, LYN, BRAF, ROCK1, PIM1, PRKCI, CDK6, ALK, CDK5, WEE1, CDK2, PRKCB, TYK2, MAPK1, PRKCQ, MAPK3, LCK, MAPK9, MAPK8, FGFR2, FGFR1, ERBB4, NEK2, ERBB2, MAPKAPK3, ADRBK1, CHEK1, MAPKAPK2, KIT, CHEK2, EPHB4, SRC, IRAK4, IGF1R, PTK2, PTK2B, TEK, ZAP70, CSF1R, ITK, MAP2K1, HCK, TGFBR1, MET, RAF1, MAPK10, KDR, RPS6KA1, FYN, PLK1, MAPK14, GSK3B, DYRK1A, GRK6, JAK1, ABCC1, JAK3, TNK2, MERTK, ABL1 6.05 9.68E-35 1.68E-34
UP_SEQ_FEATURE Protein kinase 72 15.42 5.38E-36 TTK, AURKA, BTK, CSNK2A2, AKT1, PDPK1, CSNK2A1, MAP3K9, PAK4, PRKACA, PAK1, INSR, AKT2, SYK, PRKCA, EGFR, SGK1, RET, LYN, BRAF, ROCK1, PIM1, PRKCI, CDK6, ALK, CDK5, WEE1, CDK2, PRKCB, MAPK1, PRKCQ, MAPK3, LCK, MAPK9, MAPK8, FGFR2, FGFR1, ERBB4, NEK2, ERBB2, MAPKAPK3, ADRBK1, CHEK1, MAPKAPK2, KIT, CHEK2, EPHB4, SRC, IRAK4, IGF1R, PTK2, PTK2B, TEK, ZAP70, CSF1R, ITK, MAP2K1, TGFBR1, HCK, MET, RAF1, MAPK10, KDR, FYN, PLK1, MAPK14, GSK3B, DYRK1A, GRK6, TNK2, MERTK, ABL1 6.28 2.20E-33 9.04E-33
INTERPRO Protein kinase 76 16.27 2.09E-35 TTK, AURKA, BTK, CSNK2A2, AKT1, PDPK1, CSNK2A1, MAP3K9, PAK4, PRKACA, PAK1, INSR, AKT2, SYK, PRKCA, EGFR, SGK1, RET, LYN, BRAF, ROCK1, PIM1, PRKCI, CDK6, ALK, CDK5, WEE1, CDK2, PRKCB, TYK2, MAPK1, PRKCQ, MAPK3, LCK, MAPK9, MAPK8, FGFR2, FGFR1, ERBB4, NEK2, ERBB2, MAPKAPK3, ADRBK1, CHEK1, MAPKAPK2, KIT, CHEK2, EPHB4, SRC, IRAK4, IGF1R, PTK2, PTK2B, TEK, ZAP70, CSF1R, ITK, MAP2K1, HCK, TGFBR1, MET, RAF1, MAPK10, KDR, RPS6KA1, FYN, PLK1, MAPK14, GSK3B, DYRK1A, GRK6, JAK1, JAK3, TNK2, MERTK, ABL1 5.71 9.38E-33 3.26E-32
UP_SEQ_FEATURE Nucleotide phosphate-binding region 96 20.56 1.27E-32 SPG7, TTK, AURKA, BTK, CSNK2A2, AKT1, PDPK1, CSNK2A1, MAT1A, MAP3K9, PAK4, ABCB10, PRKACA, PAK1, INSR, AKT2, SYK, PRKCA, EGFR, RET, SGK1, KIF11, LYN, BRAF, ROCK1, PIM1, PRKCI, CDK6, ALK, CDK5, WEE1, CDK2, PRKCB, TYK2, MAPK1, PNKP, PRKCQ, LCK, MAPK3, MAPK9, MAPK8, FGFR2, FGFR1, CHKA, ERBB4, NEK2, CHKB, ERBB2, MAPKAPK3, DCK, ADRBK1, CHEK1, MAPKAPK2, KIT, CHEK2, EPHB4, SRC, IRAK4, IGF1R, PTK2, PTK2B, TEK, TAP1, ZAP70, CSF1R, PDK1, ITK, DHX9, MAP2K1, HCK, PDK3, TGFBR1, PDK4, MET, RAF1, ACACB, MAPK10, ABCB6, KDR, GART, KHK, RPS6KA1, VCP, PLK1, FYN, MAPK14, GSK3B, DYRK1A, UBA3, GRK6, JAK1, TNK2, JAK3, MERTK, ABL1, CLCN5 4.08 4.17E-30 2.14E-29
GOTERM_BP_FAT Protein amino acid phosphorylation 88 18.84 1.18E-29 TTK, AURKA, BTK, CSNK2A2, AKT1, PDPK1, APP, CSNK2A1, CXCR4, MAP3K9, PAK4, PRKACA, PAK1, BRD4, INSR, AKT2, SYK, PIK3CG, PRKCA, EGFR, RET, SGK1, LYN, BRAF, ROCK1, PIM1, PRKCI, CDK6, ALK, CDK5, WEE1, CDK2, PRKCB, TYK2, MAPK1, PRKCQ, LCK, F2, MAPK3, MAPK9, MAPK8, FGFR2, FGFR1, CDK5R1, ERBB4, NEK2, ERBB2, MAPKAPK3, ADRBK1, CHEK1, MAPKAPK2, KIT, CHEK2, EPHB4, SRC, IRAK4, IGF1R, PTK2, PTK2B, BCL2, TEK, ZAP70, CSF1R, PDK1, ITK, MAP2K1, HCK, PDK3, TGFBR1, PDK4, MET, BIRC7, RAF1, MAPK10, KDR, PTPN11, RPS6KA1, PLK1, FYN, MAPK14, GSK3B, DYRK1A, GRK6, JAK1, JAK3, TNK2, MERTK, ABL1 4.00 3.79E-26 2.13E-26
GOTERM_MF_FAT Protein kinase activity 82 17.56 7.32E-27 NRP1, TTK, AURKA, BTK, CSNK2A2, AKT1, PDPK1, CSNK2A1, MAP3K9, PAK4, PRKACA, PAK1, INSR, AKT2, SYK, PRKCA, EGFR, RET, SGK1, LYN, BRAF, ROCK1, PIM1, PRKCI, CDK6, ALK, CDK5, WEE1, CDK2, PRKCB, TYK2, MAPK1, PRKCQ, MAPK3, LCK, MAPK9, MAPK8, FGFR2, FGFR1, CDK5R1, ERBB4, NEK2, ERBB2, MAPKAPK3, FKBP1A, ADRBK1, CHEK1, MAPKAPK2, KIT, CHEK2, EPHB4, SRC, IRAK4, IGF1R, PTK2, PTK2B, TEK, ZAP70, CSF1R, PDK1, ITK, MAP2K1, HCK, PDK3, TGFBR1, PDK4, MET, RAF1, MAPK10, KDR, RPS6KA1, FYN, PLK1, MAPK14, GSK3B, DYRK1A, GRK6, JAK1, JAK3, TNK2, MERTK, ABL1 3.90 6.19E-24 1.13E-23
GOTERM_BP_FAT Phosphorylation 90 19.27 2.98E-25 TTK, AURKA, BTK, CSNK2A2, AKT1, PDPK1, APP, CSNK2A1, CXCR4, MAP3K9, PAK4, PRKACA, PAK1, BRD4, INSR, AKT2, SYK, PIK3CG, PRKCA, EGFR, RET, SGK1, LYN, BRAF, ROCK1, PIM1, PRKCI, CDK6, ALK, CDK5, WEE1, CDK2, PRKCB, TYK2, MAPK1, PRKCQ, PNKP, NME2, NME1, LCK, F2, MAPK3, MAPK9, MAPK8, FGFR2, FGFR1, CDK5R1, ERBB4, NEK2, ERBB2, MAPKAPK3, ADRBK1, CHEK1, MAPKAPK2, KIT, CHEK2, EPHB4, SRC, IRAK4, IGF1R, PTK2, PTK2B, BCL2, TEK, ZAP70, CSF1R, PDK1, ITK, MAP2K1, HCK, PDK3, TGFBR1, PDK4, MET, BIRC7, RAF1, MAPK10, KDR, PTPN11, RPS6KA1, PLK1, FYN, MAPK14, GSK3B, DYRK1A, GRK6, JAK1, TNK2, JAK3, MERTK, ABL1 3.41 3.20E-22 5.41E-22
GOTERM_BP_FAT Phosphate metabolic process 99 21.20 1.53E-24 TTK, AURKA, BTK, CSNK2A2, APP, CSNK2A1, MAP3K9, PRKACA, INSR, SYK, PIK3CG, EGFR, RET, BRAF, ROCK1, PIM1, PPP1CC, WEE1, MAPK1, PNKP, PPP1CA, NME2, NME1, F2, MAPK3, MAPK9, MAPK8, FGFR2, FGFR1, CDK5R1, ERBB4, NEK2, ERBB2, MAPKAPK3, CHEK1, ADRBK1, MAPKAPK2, CHEK2, EPHB4, SRC, IRAK4, PTK2, TEK, ZAP70, CSF1R, ITK, MAP2K1, TGFBR1, MET, KDR, PTPN11, PLK1, DYRK1A, GRK6, TNK2, PTPN1, MERTK, ABL1, PTEN, AKT1, PDPK1, CXCR4, PAK4, PAK1, BRD4, AKT2, PRKCA, PPP2R1A, SGK1, LYN, PRKCI, CDK6, ALK, CDK5, CDK2, PRKCB, TYK2, PRKCQ, LCK, KIT, IGF1R, DAPP1, PTK2B, BCL2, PPP2CA, PTPRB, PDK1, HCK, PDK3, PDK4, BIRC7, RAF1, MAPK10, DUSP3, RPS6KA1, FYN, MAPK14, GSK3B, JAK1, JAK3 3.09 1.23E-21 2.78E-21
GOTERM_BP_FAT Phosphorus metabolic process 99 21.20 1.53E-24 TTK, AURKA, BTK, CSNK2A2, APP, CSNK2A1, MAP3K9, PRKACA, INSR, SYK, PIK3CG, EGFR, RET, BRAF, ROCK1, PIM1, PPP1CC, WEE1, MAPK1, PNKP, PPP1CA, NME2, NME1, F2, MAPK3, MAPK9, MAPK8, FGFR2, FGFR1, CDK5R1, ERBB4, NEK2, ERBB2, MAPKAPK3, CHEK1, ADRBK1, MAPKAPK2, CHEK2, EPHB4, SRC, IRAK4, PTK2, TEK, ZAP70, CSF1R, ITK, MAP2K1, TGFBR1, MET, KDR, PTPN11, PLK1, DYRK1A, GRK6, TNK2, PTPN1, MERTK, ABL1, PTEN, AKT1, PDPK1, CXCR4, PAK4, PAK1, BRD4, AKT2, PRKCA, PPP2R1A, SGK1, LYN, PRKCI, CDK6, ALK, CDK5, CDK2, PRKCB, TYK2, PRKCQ, LCK, KIT, IGF1R, DAPP1, PTK2B, BCL2, PPP2CA, PTPRB, PDK1, HCK, PDK3, PDK4, BIRC7, RAF1, MAPK10, DUSP3, RPS6KA1, FYN, MAPK14, GSK3B, JAK1, JAK3 3.09 1.23E-21 2.78E-21
Annotation cluster 2 Enrichment score: 23.53
SP_PIR_KEYWORDS Tyrosine protein kinase 36 7.71 1.26E-29 FGFR2, FGFR1, ERBB4, ERBB2, TTK, KIT, EPHB4, SRC, BTK, IGF1R, PTK2, PTK2B, TEK, ZAP70, INSR, SYK, CSF1R, EGFR, ITK, RET, MAP2K1, LYN, HCK, MET, ALK, WEE1, KDR, TYK2, FYN, DYRK1A, LCK, JAK1, JAK3, TNK2, MERTK, ABL1 13.36 1.33E-27 1.83E-26
INTERPRO Tyrosine protein kinase, active site 32 6.85 9.13E-25 FGFR2, FGFR1, ERBB4, ERBB2, KIT, EPHB4, SRC, BTK, IGF1R, PTK2, PTK2B, TEK, ZAP70, INSR, SYK, CSF1R, EGFR, ITK, RET, LYN, HCK, MET, ALK, KDR, TYK2, FYN, LCK, JAK1, JAK3, TNK2, MERTK, ABL1 11.79 2.73E-22 1.42E-21
INTERPRO Tyrosine protein kinase 34 7.28 3.37E-24 FGFR2, FGFR1, ERBB4, ERBB2, KIT, EPHB4, SRC, BTK, IRAK4, IGF1R, PTK2, PTK2B, MAP3K9, TEK, ZAP70, INSR, SYK, CSF1R, EGFR, ITK, RET, LYN, HCK, MET, ALK, KDR, TYK2, FYN, LCK, JAK1, JAK3, TNK2, MERTK, ABL1 10.30 7.57E-22 5.26E-21
SMART TyrKc 34 7.28 1.43E-22 FGFR2, FGFR1, ERBB4, ERBB2, KIT, EPHB4, SRC, BTK, IRAK4, IGF1R, PTK2, PTK2B, MAP3K9, TEK, ZAP70, INSR, SYK, CSF1R, EGFR, ITK, RET, LYN, HCK, MET, ALK, KDR, TYK2, FYN, LCK, JAK1, JAK3, TNK2, MERTK, ABL1 8.93 2.41E-20 1.74E-19
GOTERM_MF_FAT Protein tyrosine kinase activity 38 8.14 3.94E-20 FGFR2, FGFR1, NRP1, ERBB4, ERBB2, TTK, KIT, EPHB4, SRC, BTK, IRAK4, IGF1R, PTK2, PTK2B, TEK, ZAP70, INSR, SYK, CSF1R, EGFR, ITK, RET, MAP2K1, LYN, HCK, MET, ALK, WEE1, KDR, TYK2, FYN, DYRK1A, LCK, JAK1, JAK3, TNK2, MERTK, ABL1 6.60 1.67E-17 6.10E-17
Annotation cluster 3 Enrichment score: 16.58
UP_SEQ_FEATURE Nucleotide phosphate- binding region: ATP 96 20.56 1.27E-32 SPG7, TTK, AURKA, BTK, CSNK2A2, AKT1, PDPK1, CSNK2A1, MAT1A, MAP3K9, PAK4, ABCB10, PRKACA, PAK1, INSR, AKT2, SYK, PRKCA, EGFR, RET, SGK1, KIF11, LYN, BRAF, ROCK1, PIM1, PRKCI, CDK6, ALK, CDK5, WEE1, CDK2, PRKCB, TYK2, MAPK1, PNKP, PRKCQ, LCK, MAPK3, MAPK9, MAPK8, FGFR2, FGFR1, CHKA, ERBB4, NEK2, CHKB, ERBB2, MAPKAPK3, DCK, ADRBK1, CHEK1, MAPKAPK2, KIT, CHEK2, EPHB4, SRC, IRAK4, IGF1R, PTK2, PTK2B, TEK, TAP1, ZAP70, CSF1R, PDK1, ITK, DHX9, MAP2K1, HCK, PDK3, TGFBR1, PDK4, MET, RAF1, ACACB, MAPK10, ABCB6, KDR, GART, KHK, RPS6KA1, VCP, PLK1, FYN, MAPK14, GSK3B, DYRK1A, UBA3, GRK6, JAK1, TNK2, JAK3, MERTK, ABL1, CLCN5 4.08 4.17E-30 2.14E-29
SP_PIR_KEYWORDS ATP binding 107 22.91 7.66E-29 IDE, TTK, AURKA, BTK, CSNK2A2, CSNK2A1, MAT1A, MAP3K9, ABCB10, PRKACA, INSR, SYK, PIK3CG, EGFR, RET, BRAF, ROCK1, PIM1, WEE1, MAPK1, PNKP, NME2, NME1, MAPK3, MAPK9, MAPK8, FGFR2, FGFR1, CHKA, ERBB4, NEK2, CHKB, ERBB2, FARS2, MAPKAPK3, CHEK1, ADRBK1, CHEK2, MAPKAPK2, EPHB4, SRC, IRAK4, PTK2, TEK, ZAP70, CSF1R, DHX9, ITK, MAP2K1, TGFBR1, MET, ACACB, ABCB6, KDR, GART, ATP7A, VCP, PLK1, UBA3, DYRK1A, GRK6, TNK2, MERTK, ABL1, CLCN5, UBE2E1, HSP90AB1, SPG7, AKT1, PDPK1, PAK4, PAK1, AKT2, PRKCA, SGK1, HSP90AA1, KIF11, LYN, PRKCI, CDK6, CFTR, ALK, CDK5, CDK2, PRKCB, TYK2, PRKCQ, ADK, LCK, DCK, KIT, IGF1R, PTK2B, TAP1, PDK1, HCK, PDK3, PDK4, RAF1, MAPK10, KHK, RPS6KA1, FYN, MAPK14, GSK3B, JAK1, ABCC1, JAK3 3.32 6.74E-27 1.11E-25
SP_PIR_KEYWORDS Nucleotide binding 118 25.27 1.72E-26 HRAS, IDE, TTK, AURKA, BTK, CSNK2A2, CSNK2A1, MAT1A, MAP3K9, ABCB10, PRKACA, INSR, SYK, PIK3CG, EGFR, NUDT2, RET, BRAF, ROCK1, PIM1, WEE1, PNKP, MAPK1, NME2, NME1, PDE5A, MAPK3, MAPK9, MAPK8, FGFR2, FGFR1, CHKA, ERBB4, GNAI1, NEK2, CHKB, ERBB2, FARS2, MAPKAPK3, CHEK1, ADRBK1, CHEK2, MAPKAPK2, EPHB4, SRC, IRAK4, PTK2, TEK, RAC1, ZAP70, CSF1R, ITK, DHX9, MAP2K1, TGFBR1, MET, ACACB, ABCB6, KDR, GART, ATP7A, VCP, PLK1, UBA3, DYRK1A, GRK6, TNK2, MERTK, ABL1, CLCN5, UBE2E1, HSP90AB1, SPG7, AKT1, CDC42, PDPK1, NT5M, PAK4, PAK1, AKT2, PRKCA, SGK1, HSP90AA1, KIF11, LYN, PRKCI, CDK6, CFTR, ALK, CDK5, CDK2, PRKCB, TYK2, PRKCQ, ADK, LCK, DCK, KIT, IGF1R, PTK2B, TAP1, GIMAP2, PDK1, HCK, PDK3, PDK4, RAF1, MAPK10, PCK1, KHK, PDE2A, RPS6KA1, PYGL, FYN, MAPK14, GSK3B, JAK1, ABCC1, JAK3 2.88 1.14E-24 2.50E-23
GOTERM_MF_FAT ATP binding 110 23.56 4.31E-15 IDE, TTK, AURKA, BTK, CSNK2A2, CSNK2A1, MAT1A, MAP3K9, ABCB10, PRKACA, INSR, SYK, PIK3CG, EGFR, RET, BRAF, ROCK1, PIM1, WEE1, PNKP, MAPK1, NME2, NME1, MAPK3, MAPK9, MAPK8, FGFR2, FGFR1, CHKA, ERBB4, NEK2, CHKB, ERBB2, FARS2, MAPKAPK3, CHEK1, ADRBK1, CHEK2, MAPKAPK2, EPHB4, SRC, IRAK4, PTK2, TEK, ZAP70, CSF1R, ITK, DHX9, MAP2K1, TGFBR1, MET, ACACB, ABCB6, KDR, GART, ATP7A, VCP, PLK1, UBA3, DYRK1A, GRK6, TNK2, MERTK, ABL1, CLCN5, UBE2E1, HSP90AB1, SPG7, AKT1, PDPK1, PAK4, PAK1, AKT2, PRKCA, SGK1, HSP90AA1, KIF11, LYN, TP53, PRKCI, CDK6, CFTR, ALK, CDK5, CDK2, PRKCB, TYK2, PRKCQ, ADK, LCK, DCK, KIT, IGF1R, PTK2B, TAP1, TGM2, PDK1, HCK, PDK3, PDK4, RAF1, MAPK10, KHK, RPS6KA1, FYN, PYGL, MAPK14, GSK3B, JAK1, ABCC1, JAK3 2.15 5.23E-13 6.69E-12
GOTERM_MF_FAT Nucleoside binding 116 24.84 6.62E-15 IDE, TTK, AURKA, PNP, BTK, CSNK2A2, KDM1A, CSNK2A1, MAT1A, MAP3K9, ABCB10, PRKACA, INSR, SYK, PIK3CG, EGFR, RET, BRAF, ROCK1, PIM1, WEE1, PNKP, MAPK1, NME2, NME1, PDE5A, MAPK3, MAPK9, MAPK8, FGFR2, XDH, FGFR1, CHKA, ERBB4, NEK2, CHKB, ERBB2, FARS2, MAPKAPK3, CHEK1, ADRBK1, CHEK2, MAPKAPK2, EPHB4, SRC, IRAK4, PTK2, TEK, ZAP70, CDA, CSF1R, ITK, DHX9, MAP2K1, TGFBR1, MET, ACACB, ABCB6, KDR, GART, ATP7A, VCP, PLK1, UBA3, DYRK1A, GRK6, TNK2, MERTK, ABL1, CLCN5, UBE2E1, HSP90AB1, SPG7, AKT1, PDPK1, PAK4, PAK1, AKT2, PRKCA, SGK1, HSP90AA1, KIF11, LYN, TP53, PRKCI, CDK6, CFTR, ALK, CDK5, CDK2, PRKCB, TYK2, PRKCQ, ADK, LCK, DCK, KIT, IGF1R, PTK2B, TAP1, TGM2, PDK1, HCK, PDK3, PDK4, RAF1, MAPK10, PCK1, KHK, RPS6KA1, PYGL, FYN, MAPK14, GSK3B, JAK1, ABCC1, JAK3 2.08 6.26E-13 1.03E-11
GOTERM_MF_FAT Adenyl ribonucleotide binding 110 23.56 1.07E-14 IDE, TTK, AURKA, BTK, CSNK2A2, CSNK2A1, MAT1A, MAP3K9, ABCB10, PRKACA, INSR, SYK, PIK3CG, EGFR, RET, BRAF, ROCK1, PIM1, WEE1, PNKP, MAPK1, NME2, NME1, MAPK3, MAPK9, MAPK8, FGFR2, FGFR1, CHKA, ERBB4, NEK2, CHKB, ERBB2, FARS2, MAPKAPK3, CHEK1, ADRBK1, CHEK2, MAPKAPK2, EPHB4, SRC, IRAK4, PTK2, TEK, ZAP70, CSF1R, ITK, DHX9, MAP2K1, TGFBR1, MET, ACACB, ABCB6, KDR, GART, ATP7A, VCP, PLK1, UBA3, DYRK1A, GRK6, TNK2, MERTK, ABL1, CLCN5, UBE2E1, HSP90AB1, SPG7, AKT1, PDPK1, PAK4, PAK1, AKT2, PRKCA, SGK1, HSP90AA1, KIF11, LYN, TP53, PRKCI, CDK6, CFTR, ALK, CDK5, CDK2, PRKCB, TYK2, PRKCQ, ADK, LCK, DCK, KIT, IGF1R, PTK2B, TAP1, TGM2, PDK1, HCK, PDK3, PDK4, RAF1, MAPK10, KHK, RPS6KA1, FYN, PYGL, MAPK14, GSK3B, JAK1, ABCC1, JAK3 2.12 9.11E-13 1.67E-11
GOTERM_MF_FAT Purine nucleoside binding 114 24.41 2.63E-14 IDE, TTK, AURKA, BTK, CSNK2A2, KDM1A, CSNK2A1, MAT1A, MAP3K9, ABCB10, PRKACA, INSR, SYK, PIK3CG, EGFR, RET, BRAF, ROCK1, PIM1, WEE1, PNKP, MAPK1, NME2, NME1, PDE5A, MAPK3, MAPK9, MAPK8, FGFR2, XDH, FGFR1, CHKA, ERBB4, NEK2, CHKB, ERBB2, FARS2, MAPKAPK3, CHEK1, ADRBK1, CHEK2, MAPKAPK2, EPHB4, SRC, IRAK4, PTK2, TEK, ZAP70, CSF1R, ITK, DHX9, MAP2K1, TGFBR1, MET, ACACB, ABCB6, KDR, GART, ATP7A, VCP, PLK1, UBA3, DYRK1A, GRK6, TNK2, MERTK, ABL1, CLCN5, UBE2E1, HSP90AB1, SPG7, AKT1, PDPK1, PAK4, PAK1, AKT2, PRKCA, SGK1, HSP90AA1, KIF11, LYN, TP53, PRKCI, CDK6, CFTR, ALK, CDK5, CDK2, PRKCB, TYK2, PRKCQ, ADK, LCK, DCK, KIT, IGF1R, PTK2B, TAP1, TGM2, PDK1, HCK, PDK3, PDK4, RAF1, MAPK10, PCK1, KHK, RPS6KA1, PYGL, FYN, MAPK14, GSK3B, JAK1, ABCC1, JAK3 2.05 2.02E-12 4.07E-11
GOTERM_MF_FAT Adenyl nucleotide binding 112 23.98 5.87E-14 IDE, TTK, AURKA, BTK, CSNK2A2, KDM1A, CSNK2A1, MAT1A, MAP3K9, ABCB10, PRKACA, INSR, SYK, PIK3CG, EGFR, RET, BRAF, ROCK1, PIM1, WEE1, PNKP, MAPK1, NME2, NME1, MAPK3, MAPK9, MAPK8, FGFR2, XDH, FGFR1, CHKA, ERBB4, NEK2, CHKB, ERBB2, FARS2, MAPKAPK3, CHEK1, ADRBK1, CHEK2, MAPKAPK2, EPHB4, SRC, IRAK4, PTK2, TEK, ZAP70, CSF1R, ITK, DHX9, MAP2K1, TGFBR1, MET, ACACB, ABCB6, KDR, GART, ATP7A, VCP, PLK1, UBA3, DYRK1A, GRK6, TNK2, MERTK, ABL1, CLCN5, UBE2E1, HSP90AB1, SPG7, AKT1, PDPK1, PAK4, PAK1, AKT2, PRKCA, SGK1, HSP90AA1, KIF11, LYN, TP53, PRKCI, CDK6, CFTR, ALK, CDK5, CDK2, PRKCB, TYK2, PRKCQ, ADK, LCK, DCK, KIT, IGF1R, PTK2B, TAP1, TGM2, PDK1, HCK, PDK3, PDK4, RAF1, MAPK10, KHK, RPS6KA1, FYN, PYGL, MAPK14, GSK3B, JAK1, ABCC1, JAK3 2.05 3.82E-12 9.08E-11
GOTERM_MF_FAT Nucleotide binding 137 29.34 4.05E-12 NCBP2, HRAS, HMGCR, IDE, TTK, AURKA, BTK, CSNK2A2, KDM1A, CSNK2A1, MAT1A, MAP3K9, ABCB10, PRKACA, INSR, SYK, PIK3CG, EGFR, RET, NUDT2, ROCK1, BRAF, PIM1, PPARGC1A, WEE1, POR, PNKP, MAPK1, NME2, NME1, PDE5A, MAPK3, MAPK9, MAPK8, XDH, FGFR2, FGFR1, CHKA, HSD17B10, ME2, ERBB4, GNAI1, NEK2, FARS2, CHKB, ERBB2, MAPKAPK3, CHEK1, ADRBK1, CHEK2, MAPKAPK2, EPHB4, SRC, IRAK4, PTK2, TEK, RAC1, ZAP70, CSF1R, ITK, DHX9, MAP2K1, TGFBR1, MET, NXF1, ACACB, ABCB6, KDR, GART, ATP7A, DHFR, VCP, PLK1, UBA3, DYRK1A, GRK6, TNK2, MERTK, ABL1, PARP1, UBE2E1, CLCN5, HSP90AB1, SPG7, AKT1, CDC42, PDPK1, PARN, NT5M, PAK4, PAK1, AKT2, PRKCA, SGK1, HSP90AA1, KIF11, LYN, PRKCI, TP53, CFTR, CDK6, CBR3, ALK, CDK5, CDK2, PRKCB, TYK2, PRKCQ, G6PD, ADK, LCK, DCK, ADH5, KIT, TYMS, IGF1R, PTK2B, ADH4, TAP1, TGM2, GIMAP2, PDK1, HCK, PDK3, PDK4, SIRT5, RAF1, MAPK10, PCK1, KHK, RPS6KA1, PYGL, FYN, MAPK14, GSK3B, JAK1, ABCC1, JAK3 1.76 2.28E-10 6.26E-09
GOTERM_MF_FAT Ribonucleotide binding 118 25.27 9.49E-12 HRAS, IDE, TTK, AURKA, BTK, CSNK2A2, CSNK2A1, MAT1A, MAP3K9, ABCB10, PRKACA, INSR, SYK, PIK3CG, EGFR, RET, NUDT2, BRAF, ROCK1, PIM1, WEE1, PNKP, MAPK1, NME2, NME1, PDE5A, MAPK3, MAPK9, MAPK8, FGFR2, FGFR1, CHKA, ERBB4, GNAI1, NEK2, CHKB, ERBB2, FARS2, MAPKAPK3, CHEK1, ADRBK1, CHEK2, MAPKAPK2, EPHB4, SRC, IRAK4, PTK2, TEK, RAC1, ZAP70, CSF1R, ITK, DHX9, MAP2K1, TGFBR1, MET, ACACB, ABCB6, KDR, GART, ATP7A, VCP, PLK1, UBA3, DYRK1A, GRK6, TNK2, MERTK, ABL1, CLCN5, UBE2E1, HSP90AB1, SPG7, AKT1, CDC42, PDPK1, PAK4, PAK1, AKT2, PRKCA, SGK1, HSP90AA1, KIF11, LYN, TP53, PRKCI, CDK6, CFTR, ALK, CDK5, CDK2, PRKCB, TYK2, PRKCQ, ADK, LCK, DCK, KIT, IGF1R, PTK2B, TAP1, TGM2, GIMAP2, PDK1, HCK, PDK3, PDK4, RAF1, MAPK10, PCK1, KHK, RPS6KA1, PYGL, FYN, MAPK14, GSK3B, JAK1, ABCC1, JAK3 1.85 4.72E-10 1.47E-08
GOTERM_MF_FAT Purine ribonucleotide binding 118 25.27 9.49E-12 HRAS, IDE, TTK, AURKA, BTK, CSNK2A2, CSNK2A1, MAT1A, MAP3K9, ABCB10, PRKACA, INSR, SYK, PIK3CG, EGFR, RET, NUDT2, BRAF, ROCK1, PIM1, WEE1, PNKP, MAPK1, NME2, NME1, PDE5A, MAPK3, MAPK9, MAPK8, FGFR2, FGFR1, CHKA, ERBB4, GNAI1, NEK2, CHKB, ERBB2, FARS2, MAPKAPK3, CHEK1, ADRBK1, CHEK2, MAPKAPK2, EPHB4, SRC, IRAK4, PTK2, TEK, RAC1, ZAP70, CSF1R, ITK, DHX9, MAP2K1, TGFBR1, MET, ACACB, ABCB6, KDR, GART, ATP7A, VCP, PLK1, UBA3, DYRK1A, GRK6, TNK2, MERTK, ABL1, CLCN5, UBE2E1, HSP90AB1, SPG7, AKT1, CDC42, PDPK1, PAK4, PAK1, AKT2, PRKCA, SGK1, HSP90AA1, KIF11, LYN, TP53, PRKCI, CDK6, CFTR, ALK, CDK5, CDK2, PRKCB, TYK2, PRKCQ, ADK, LCK, DCK, KIT, IGF1R, PTK2B, TAP1, TGM2, GIMAP2, PDK1, HCK, PDK3, PDK4, RAF1, MAPK10, PCK1, KHK, RPS6KA1, PYGL, FYN, MAPK14, GSK3B, JAK1, ABCC1, JAK3 1.85 4.72E-10 1.47E-08
GOTERM_MF_FAT Purine nucleotide binding 120 25.70 3.44E-11 HRAS, IDE, TTK, AURKA, BTK, CSNK2A2, KDM1A, CSNK2A1, MAT1A, MAP3K9, ABCB10, PRKACA, INSR, SYK, PIK3CG, EGFR, RET, NUDT2, BRAF, ROCK1, PIM1, WEE1, PNKP, MAPK1, NME2, NME1, PDE5A, MAPK3, MAPK9, MAPK8, FGFR2, XDH, FGFR1, CHKA, ERBB4, GNAI1, NEK2, CHKB, ERBB2, FARS2, MAPKAPK3, CHEK1, ADRBK1, CHEK2, MAPKAPK2, EPHB4, SRC, IRAK4, PTK2, TEK, RAC1, ZAP70, CSF1R, ITK, DHX9, MAP2K1, TGFBR1, MET, ACACB, ABCB6, KDR, GART, ATP7A, VCP, PLK1, UBA3, DYRK1A, GRK6, TNK2, MERTK, ABL1, CLCN5, UBE2E1, HSP90AB1, SPG7, AKT1, CDC42, PDPK1, PAK4, PAK1, AKT2, PRKCA, SGK1, HSP90AA1, KIF11, LYN, TP53, PRKCI, CDK6, CFTR, ALK, CDK5, CDK2, PRKCB, TYK2, PRKCQ, ADK, LCK, DCK, KIT, IGF1R, PTK2B, TAP1, TGM2, GIMAP2, PDK1, HCK, PDK3, PDK4, RAF1, MAPK10, PCK1, KHK, RPS6KA1, PYGL, FYN, MAPK14, GSK3B, JAK1, ABCC1, JAK3 1.81 1.45E-09 5.32E-08
Annotation cluster 4 Enrichment score: 16.40
UP_SEQ_FEATURE DNA-binding region: nuclear receptor 20 4.28 2.07E-19 PPARA, PPARD, AR, RARG, THRA, THRB, RXRA, PPARG, ESRRG, ESR1, NR3C1, ESR2, NR1H2, PGR, VDR, NR1I3, NR1I2, RARB, NR1H4, NR1H3 18.19 5.65E-17 3.48E-16
UP_SEQ_FEATURE Zinc finger region: NR C4 type 20 4.28 2.07E-19 PPARA, PPARD, AR, RARG, THRA, THRB, RXRA, PPARG, ESRRG, ESR1, NR3C1, ESR2, NR1H2, PGR, VDR, NR1I3, NR1I2, RARB, NR1H4, NR1H3 18.19 5.65E-17 3.48E-16
INTERPRO Zinc finger, nuclear hormone receptor type 20 4.28 4.10E-18 PPARA, PPARD, AR, RARG, THRA, THRB, RXRA, PPARG, ESRRG, ESR1, NR3C1, ESR2, NR1H2, PGR, VDR, NR1I3, NR1I2, RARB, NR1H4, NR1H3 15.54 7.36E-16 6.39E-15
INTERPRO Nuclear hormone receptor, ligand binding, core 20 4.28 1.08E-17 PPARA, PPARD, AR, RARG, THRA, THRB, RXRA, PPARG, ESRRG, ESR1, NR3C1, ESR2, NR1H2, PGR, VDR, NR1I3, NR1I2, RARB, NR1H4, NR1H3 14.90 1.61E-15 1.68E-14
INTERPRO Nuclear hormone receptor, ligand binding 20 4.28 1.08E-17 PPARA, PPARD, AR, RARG, THRA, THRB, RXRA, PPARG, ESRRG, ESR1, NR3C1, ESR2, NR1H2, PGR, VDR, NR1I3, NR1I2, RARB, NR1H4, NR1H3 14.90 1.61E-15 1.68E-14
SMART ZnF_C4 20 4.28 4.44E-17 PPARA, PPARD, AR, RARG, THRA, THRB, RXRA, PPARG, ESRRG, ESR1, NR3C1, ESR2, NR1H2, PGR, VDR, NR1I3, NR1I2, RARB, NR1H4, NR1H3 13.47 3.73E-15 5.40E-14
SMART HOLI 20 4.28 1.16E-16 PPARA, PPARD, AR, RARG, THRA, THRB, RXRA, PPARG, ESRRG, ESR1, NR3C1, ESR2, NR1H2, PGR, VDR, NR1I3, NR1I2, RARB, NR1H4, NR1H3 12.91 6.22E-15 1.33E-13
INTERPRO Steroid hormone receptor 19 4.07 1.59E-16 PPARA, PPARD, RARG, THRA, THRB, RXRA, PPARG, ESRRG, ESR1, NR3C1, ESR2, NR1H2, PGR, VDR, NR1I3, NR1I2, RARB, NR1H4, NR1H3 14.45 1.42E-14 1.78E-13
GOTERM_MF_FAT Steroid hormone receptor activity 20 4.28 8.16E-16 PPARA, PPARD, AR, RARG, THRA, THRB, RXRA, PPARG, ESRRG, ESR1, NR3C1, ESR2, NR1H2, PGR, VDR, NR1I3, NR1I2, RARB, NR1H4, NR1H3 11.78 1.31E-13 1.20E-12
INTERPRO Zinc finger, NHR/GATA- type 19 4.07 8.68E-16 PPARA, PPARD, AR, RARG, THRA, THRB, PPARG, ESRRG, ESR1, NR3C1, ESR2, NR1H2, PGR, VDR, NR1I3, NR1I2, RARB, NR1H4, NR1H3 13.32 7.25E-14 1.39E-12
GOTERM_MF_FAT Ligand-dependent nuclear receptor activity 20 4.28 3.24E-14 PPARA, PPARD, AR, RARG, THRA, THRB, RXRA, PPARG, ESRRG, ESR1, NR3C1, ESR2, NR1H2, PGR, VDR, NR1I3, NR1I2, RARB, NR1H4, NR1H3 9.95 2.29E-12 5.01E-11
Annotation cluster 5 Enrichment score: 15.83
SP_PIR_KEYWORDS Protease 60 12.85 5.06E-25 SPG7, METAP1, METAP2, MMP-9, IDE, MMP-8, MMP-7, MMP-3, MMP-1, MMP-20, APP, CASP3, LPA, HTRA1, CASP7, CASP8, CPA1, CFD, CASP1, TPSB2, DPP4, F11, F10, GZMA, ELANE, F9, GZMB, MMP-16, CTSS, F7, MMP-13, MMP-12, NAALAD2, CTSK, FOLH1, BACE2, ST14, BACE1, F2, CTSD, ADAM17, CTSB, ADAMTS5, CTSG, ADAMTS4, PREP, MME, ACE, ECE1, REN, PRSS3, PLAT, CPA4, HPN, KLK5, PLG, LTA4H, CMA1, CPB2, PLAU 5.11 2.43E-23 7.34E-22
GOTERM_MF_FAT Endopeptidase activity 51 10.92 1.01E-16 SPG7, MMP-9, IDE, MMP-8, MMP-7, MMP-3, MMP-1, CASP3, MMP-20, LPA, HTRA1, CASP7, CASP8, SERPINE1, CFD, CASP1, TPSB2, DPP4, F11, F10, GZMA, ELANE, F9, GZMB, MMP-16, CTSS, F7, MMP-13, MMP-12, CTSK, BACE2, ST14, F2, BACE1, CTSD, ADAM17, CTSB, ADAMTS5, CTSG, ADAMTS4, PREP, MME, ECE1, REN, PRSS3, PLAT, HPN, KLK5, PLG, CMA1, PLAU 3.92 3.13E-14 1.67E-13
GOTERM_MF_FAT Peptidase activity 62 13.28 2.65E-15 SPG7, METAP1, METAP2, MMP-9, IDE, MMP-8, MMP-7, MMP-3, MMP-1, MMP-20, APP, CASP3, LPA, HTRA1, CASP7, CASP8, SERPINE1, CPA1, CFD, CASP1, TPSB2, DPP4, F11, F10, GZMA, ELANE, F9, GZMB, MMP-16, CTSS, F7, MMP-13, MMP-12, NAALAD2, CTSK, FOLH1, BACE2, ST14, BACE1, F2, CTSD, ADAM17, CTSB, CTSG, ADAMTS5, ADAMTS4, PREP, MME, ACE, ECE1, REN, PRSS3, PLAT, CPA4, HPN, KLK5, PLG, QPCT, LTA4H, CMA1, CPB2, PLAU 3.12 3.76E-13 4.12E-12
GOTERM_MF_FAT Peptidase activity, acting on L-amino acid peptides 60 12.85 4.84E-15 SPG7, METAP1, METAP2, MMP-9, IDE, MMP-8, MMP-7, MMP-3, MMP-1, MMP-20, CASP3, LPA, HTRA1, CASP7, CASP8, SERPINE1, CPA1, CFD, CASP1, TPSB2, DPP4, F11, F10, GZMA, ELANE, F9, GZMB, MMP-16, CTSS, F7, MMP-13, MMP-12, NAALAD2, CTSK, FOLH1, BACE2, ST14, BACE1, F2, CTSD, ADAM17, CTSB, ADAMTS5, CTSG, ADAMTS4, PREP, MME, ACE, ECE1, REN, PRSS3, PLAT, CPA4, HPN, KLK5, PLG, LTA4H, CMA1, CPB2, PLAU 3.15 5.17E-13 7.55E-12
GOTERM_BP_FAT Proteolysis 76 16.27 1.10E-10 METAP1, SPG7, METAP2, TSG101, MMP-9, IDE, MMP-8, MMP-7, MMP-3, C1QC, MMP-1, MMP-20, CASP3, LPA, HTRA1, CASP7, CASP8, CPA1, CASP1, CFD, TPSB2, DPP4, F11, F10, GZMA, ELANE, F9, MMP- 16, UBR2, GZMB, CTSS, F7, MMP-13, MMP-12, C1QA, PRKCQ, C1QB, NAALAD2, CTSK, FOLH1, BACE2, ST14, BACE1, F2, CTSD, ADAM17, MDM2, CTSB, CTSG, ADAMTS5, ADAMTS4, PREP, XIAP, MME, NEDD8, ACE, ECE1, REN, PRSS3, TRAF6, SPOP, PLAT, CPA4, HPN, KLK5, PLG, BRCA1, NAE1, QPCT, VCP, UBA3, CMA1, LTA4H, CPB2, PLAU, UBE2E1 2.19 1.32E-08 2.00E-07
Annotation cluster 6 Enrichment score: 14.64
SP_PIR_KEYWORDS Serine/threonine protein kinase 44 9.42 3.20E-17 NEK2, MAPKAPK3, TTK, CHEK1, ADRBK1, AURKA, MAPKAPK2, CHEK2, CSNK2A2, IRAK4, AKT1, PDPK1, CSNK2A1, MAP3K9, PAK4, PRKACA, PAK1, AKT2, PRKCA, SGK1, MAP2K1, ROCK1, BRAF, TGFBR1, PIM1, PRKCI, RAF1, CDK6, MAPK10, CDK5, WEE1, CDK2, PRKCB, MAPK1, PRKCQ, RPS6KA1, PLK1, MAPK14, GSK3B, DYRK1A, MAPK3, GRK6, MAPK9, MAPK8 4.76 1.20E-15 4.64E-14
INTERPRO Serine/threonine protein kinase 38 8.14 2.09E-16 NEK2, MAPKAPK3, TTK, CHEK1, ADRBK1, AURKA, MAPKAPK2, CHEK2, CSNK2A2, AKT1, PDPK1, CSNK2A1, PAK4, PRKACA, PAK1, AKT2, PRKCA, SGK1, MAP2K1, ROCK1, PIM1, PRKCI, CDK6, MAPK10, CDK5, CDK2, PRKCB, MAPK1, PRKCQ, RPS6KA1, PLK1, MAPK14, GSK3B, DYRK1A, MAPK3, GRK6, MAPK9, MAPK8 5.25 2.49E-14 3.44E-13
INTERPRO Serine/threonine protein kinase, active site 44 9.42 4.17E-16 NEK2, MAPKAPK3, TTK, CHEK1, ADRBK1, AURKA, MAPKAPK2, CHEK2, CSNK2A2, IRAK4, AKT1, PDPK1, CSNK2A1, MAP3K9, PAK4, PRKACA, PAK1, AKT2, PRKCA, SGK1, MAP2K1, ROCK1, BRAF, TGFBR1, PIM1, PRKCI, RAF1, CDK6, MAPK10, CDK5, WEE1, CDK2, PRKCB, MAPK1, PRKCQ, RPS6KA1, PLK1, MAPK14, GSK3B, DYRK1A, MAPK3, GRK6, MAPK9, MAPK8 4.44 4.43E-14 6.88E-13
INTERPRO Serine/threonine protein kinase related 44 9.42 6.21E-16 NEK2, MAPKAPK3, TTK, CHEK1, ADRBK1, AURKA, MAPKAPK2, CHEK2, CSNK2A2, IRAK4, AKT1, PDPK1, CSNK2A1, MAP3K9, PAK4, PRKACA, PAK1, AKT2, PRKCA, SGK1, MAP2K1, ROCK1, BRAF, TGFBR1, PIM1, PRKCI, RAF1, CDK6, MAPK10, CDK5, WEE1, CDK2, PRKCB, MAPK1, PRKCQ, RPS6KA1, PLK1, MAPK14, GSK3B, DYRK1A, MAPK3, GRK6, MAPK9, MAPK8 4.38 5.98E-14 1.03E-12
SMART S_TKc 38 8.14 1.09E-14 NEK2, MAPKAPK3, TTK, CHEK1, ADRBK1, AURKA, MAPKAPK2, CHEK2, CSNK2A2, AKT1, PDPK1, CSNK2A1, PAK4, PRKACA, PAK1, AKT2, PRKCA, SGK1, MAP2K1, ROCK1, PIM1, PRKCI, CDK6, MAPK10, CDK5, CDK2, PRKCB, MAPK1, PRKCQ, RPS6KA1, PLK1, MAPK14, GSK3B, DYRK1A, MAPK3, GRK6, MAPK9, MAPK8 4.55 4.57E-13 1.32E-11
GOTERM_MF_FAT Protein serine/threonine kinase activity 47 10.06 7.51E-12 CDK5R1, NEK2, MAPKAPK3, TTK, CHEK1, FKBP1A, ADRBK1, AURKA, MAPKAPK2, CHEK2, CSNK2A2, IRAK4, AKT1, PDPK1, CSNK2A1, MAP3K9, PAK4, PRKACA, PAK1, AKT2, EGFR, PRKCA, SGK1, MAP2K1, ROCK1, BRAF, TGFBR1, PIM1, PRKCI, RAF1, CDK6, MAPK10, CDK5, WEE1, CDK2, PRKCB, MAPK1, PRKCQ, RPS6KA1, PLK1, MAPK14, GSK3B, DYRK1A, MAPK3, GRK6, MAPK9, MAPK8 3.15 3.97E-10 1.16E-08
Annotation cluster 7 Enrichment score: 14.56
GOTERM_BP_FAT Regulation of programmed cell death 74 15.85 2.10E-15 HRAS, MMP-9, PTEN, BTK, AKT1, CASP3, APP, FNTA, TIAM1, CASP8, RARB, CASP1, NQO1, PIK3CG, EGFR, PRKCA, PPP2R1A, NUDT2, RARG, BRAF, ROCK1, RXRA, PIM1, ESR1, TP53, PRKCI, ESR2, F7, CDK5, MAPK1, CD38, NME2, NME1, LCK, F2, MAPK9, ADAM17, MAPK8, CTSB, GSTP1, TRAF2, CDK5R1, YWHAZ, XIAP, ADORA2A, ERBB2, BCL2L1, KIT, NR3C1, SFN, CHEK2, SRC, MIF, VDR, IGF1R, ALB, BCL2, PPP2CA, RAC1, TGM2, BCL6, GLO1, TRAF6, LGALS1, TGFBR1, BIRC7, IGF1, PLG, BRCA1, NAE1, ATP7A, VCP, GSK3B, ABL1, IL2 2.76 7.55E-13 3.83E-12
GOTERM_BP_FAT Regulation of cell death 74 15.85 2.52E-15 HRAS, MMP-9, PTEN, BTK, AKT1, CASP3, APP, FNTA, TIAM1, CASP8, RARB, CASP1, NQO1, PIK3CG, EGFR, PRKCA, PPP2R1A, NUDT2, RARG, BRAF, ROCK1, RXRA, PIM1, ESR1, TP53, PRKCI, ESR2, F7, CDK5, MAPK1, CD38, NME2, NME1, LCK, F2, MAPK9, ADAM17, MAPK8, CTSB, GSTP1, TRAF2, CDK5R1, YWHAZ, XIAP, ADORA2A, ERBB2, BCL2L1, KIT, NR3C1, SFN, CHEK2, SRC, MIF, VDR, IGF1R, ALB, BCL2, PPP2CA, RAC1, TGM2, BCL6, GLO1, TRAF6, LGALS1, TGFBR1, BIRC7, IGF1, PLG, BRCA1, NAE1, ATP7A, VCP, GSK3B, ABL1, IL2 2.75 8.23E-13 4.63E-12
GOTERM_BP_FAT Regulation of apoptosis 73 15.63 4.05E-15 HRAS, MMP-9, PTEN, BTK, AKT1, CASP3, APP, FNTA, TIAM1, CASP8, RARB, CASP1, NQO1, PIK3CG, PRKCA, EGFR, PPP2R1A, NUDT2, RARG, BRAF, ROCK1, RXRA, PIM1, ESR1, TP53, PRKCI, ESR2, F7, CDK5, MAPK1, CD38, NME2, NME1, LCK, F2, MAPK9, ADAM17, MAPK8, CTSB, GSTP1, TRAF2, CDK5R1, YWHAZ, XIAP, ADORA2A, ERBB2, BCL2L1, NR3C1, SFN, CHEK2, SRC, MIF, VDR, IGF1R, ALB, BCL2, PPP2CA, RAC1, TGM2, BCL6, GLO1, TRAF6, LGALS1, TGFBR1, BIRC7, IGF1, PLG, BRCA1, NAE1, ATP7A, VCP, GSK3B, ABL1, IL2 2.75 1.17E-12 7.25E-12
Annotation cluster 8 Enrichment score: 10.94
GOTERM_BP_FAT Regulation of phosphorylation 49 10.49 1.72E-12 HMGCR, TTK, PTEN, AKT1, CDC42, APP, CASP3, PDPK1, CXCR4, MAP3K9, PRKACA, PAK1, INSR, SYK, PRKCA, EGFR, PPP2R1A, LYN, ELANE, PIM1, RB1, CDK5, NCK2, F2, ADAM17, TRAF2, CDK5R1, ADORA2A, ERBB2, CHEK1, FKBP1A, SFN, KIT, PIN1, PTK2B, PPP2CA, BCL2, RAC1, TRAF6, MAP2K1, TGFBR1, MET, BIRC7, IGF1, PTPN11, ATP7A, FABP4, TNK2, IL2 3.19 3.25E-10 3.12E-09
GOTERM_BP_FAT Regulation of phosphorus metabolic process 50 10.71 2.04E-12 HMGCR, TTK, PTEN, AKT1, CDC42, APP, CASP3, PDPK1, CXCR4, MAP3K9, PRKACA, PAK1, INSR, SYK, PRKCA, EGFR, PPP2R1A, LYN, ELANE, PIM1, RB1, CDK5, NCK2, F2, ADAM17, TRAF2, CDK5R1, ADORA2A, ERBB2, CHEK1, FKBP1A, SFN, KIT, PIN1, PTK2B, PPP2CA, BCL2, RAC1, TRAF6, MAP2K1, PLEK, TGFBR1, MET, BIRC7, IGF1, PTPN11, ATP7A, FABP4, TNK2, IL2 3.13 3.65E-10 3.70E-09
GOTERM_BP_FAT Regulation of phosphate metabolic process 50 10.71 2.04E-12 HMGCR, TTK, PTEN, AKT1, CDC42, APP, CASP3, PDPK1, CXCR4, MAP3K9, PRKACA, PAK1, INSR, SYK, PRKCA, EGFR, PPP2R1A, LYN, ELANE, PIM1, RB1, CDK5, NCK2, F2, ADAM17, TRAF2, CDK5R1, ADORA2A, ERBB2, CHEK1, FKBP1A, SFN, KIT, PIN1, PTK2B, PPP2CA, BCL2, RAC1, TRAF6, MAP2K1, PLEK, TGFBR1, MET, BIRC7, IGF1, PTPN11, ATP7A, FABP4, TNK2, IL2 3.13 3.65E-10 3.70E-09
GOTERM_BP_FAT Regulation of transferase activity 41 8.78 3.67E-11 TRAF2, CDK5R1, HMGCR, ADORA2A, ERBB2, PPARG, CHEK1, SFN, KIT, PTEN, AKT1, CDC42, PDPK1, CASP3, APP, CXCR4, PTK2B, MAP3K9, PPP2CA, RAC1, PRKACA, PAK1, TRAF6, INSR, SYK, EGFR, PRKCA, PPP2R1A, MAP2K1, TGFBR1, ELANE, MET, PIM1, BIRC7, RB1, CDK5, PTPN11, NCK2, FABP4, ADAM17, IL2 3.34 4.93E-09 6.67E-08
GOTERM_BP_FAT Regulation of kinase activity 40 8.56531 4.06E-11 TRAF2, CDK5R1, HMGCR, ADORA2A, ERBB2, CHEK1, SFN, KIT, PTEN, AKT1, CDC42, CASP3, APP, PDPK1, CXCR4, PTK2B, MAP3K9, PPP2CA, RAC1, PRKACA, PAK1, TRAF6, INSR, SYK, EGFR, PRKCA, PPP2R1A, MAP2K1, TGFBR1, ELANE, MET, PIM1, BIRC7, RB1, CDK5, PTPN11, NCK2, FABP4, ADAM17, IL2 3.40 5.24E-09 7.37E-08
GOTERM_BP_FAT Regulation of protein kinase activity 38 8.145 2.24E-10 TRAF2, CDK5R1, HMGCR, ADORA2A, ERBB2, CHEK1, SFN, KIT, PTEN, AKT1, CASP3, APP, PDPK1, CXCR4, PTK2B, MAP3K9, PPP2CA, PRKACA, PAK1, TRAF6, INSR, SYK, EGFR, PRKCA, PPP2R1A, MAP2K1, TGFBR1, ELANE, MET, PIM1, BIRC7, RB1, CDK5, PTPN11, NCK2, FABP4, ADAM17, IL2 3.34 2.33E-08 4.07E-07
Annotation cluster 9 Enrichment score: 10.39
SP_PIR_KEYWORDS Serine proteinase 17 3.64 9.89E-14 PLAT, F11, PREP, HPN, F10, GZMA, F9, GZMB, F7, PLG, LPA, PRSS3, F2, CMA1, TPSB2, CTSG, PLAU 12.97 2.18E-12 1.44E-10
UP_SEQ_FEATURE Charge relay system 28 6.00 3.26E-13 PREP, HMGCR, LPA, HTRA1, BCHE, PRSS3, CFD, TPSB2, DPP4, F11, PLAT, HPN, F10, CES1, GZMA, KLK5, ELANE, F9, GZMB, F7, PLG, NAALAD2, FOLH1, ST14, F2, CMA1, CTSG, PLAU 5.85 4.45E-11 5.48E-10
SP_PIR_KEYWORDS Serine protease 23 4.93 1.74E-12 PLAT, F11, PREP, HPN, F10, GZMA, KLK5, ELANE, F9, GZMB, F7, PLG, LPA, HTRA1, ST14, F2, PRSS3, CMA1, TPSB2, CFD, DPP4, CTSG, PLAU 6.97 3.68E-11 2.53E-09
UP_SEQ_FEATURE Peptidase S1 20 4.28 9.94E-12 PLAT, F11, HPN, F10, GZMA, KLK5, ELANE, F9, GZMB, F7, PLG, LPA, ST14, F2, PRSS3, CMA1, TPSB2, CFD, CTSG, PLAU 7.72 1.08E-09 1.67E-08
INTERPRO Peptidase S1 and S6, chymotrypsin/Hap 21 4.50 6.51E-11 PLAT, F11, HPN, F10, GZMA, KLK5, ELANE, F9, GZMB, F7, PLG, LPA, HTRA1, ST14, F2, PRSS3, CMA1, TPSB2, CFD, CTSG, PLAU 6.47 4.50E-09 1.01E-07
INTERPRO Peptidase S1A, chymotrypsin 20 4.28 6.91E-11 PLAT, F11, HPN, F10, GZMA, KLK5, ELANE, F9, GZMB, F7, PLG, LPA, ST14, F2, PRSS3, CMA1, TPSB2, CFD, CTSG, PLAU 6.87 4.43E-09 1.08E-07
INTERPRO Peptidase S1/S6, chymotrypsin/Hap, active site 20 4.28 8.22E-11 PLAT, F11, HPN, F10, GZMA, KLK5, ELANE, F9, GZMB, F7, PLG, LPA, ST14, F2, PRSS3, CMA1, TPSB2, CFD, CTSG, PLAU 6.81 4.92E-09 1.28E-07
GOTERM_MF_FAT Serine-type endopeptidase activity 25 5.35 5.61E-10 PREP, MMP-8, LPA, HTRA1, PRSS3, SERPINE1, CFD, TPSB2, DPP4, F11, PLAT, HPN, F10, GZMA, KLK5, ELANE, F9, GZMB, F7, PLG, F2, ST14, CMA1, CTSG, PLAU 4.68 2.26E-08 8.67E-07
SMART Tryp_SPc 21 4.50 6.36E-10 PLAT, F11, HPN, F10, GZMA, KLK5, ELANE, F9, GZMB, F7, PLG, LPA, HTRA1, ST14, F2, PRSS3, CMA1, TPSB2, CFD, CTSG, PLAU 5.61 2.14E-08 7.74E-07
GOTERM_MF_FAT Serine-type peptidase activity 26 5.57 2.29E-09 PREP, MMP-8, LPA, HTRA1, PRSS3, SERPINE1, CFD, TPSB2, DPP4, F11, PLAT, HPN, F10, GZMA, KLK5, ELANE, F9, GZMB, F7, PLG, NAALAD2, ST14, F2, CMA1, CTSG, PLAU 4.21 8.44E-08 3.55E-06
GOTERM_MF_FAT Serine hydrolase activity 26 5.57 2.90E-09 PREP, MMP-8, LPA, HTRA1, PRSS3, SERPINE1, CFD, TPSB2, DPP4, F11, PLAT, HPN, F10, GZMA, KLK5, ELANE, F9, GZMB, F7, PLG, NAALAD2, ST14, F2, CMA1, CTSG, PLAU 4.17 1.02E-07 4.49E-06
Annotation cluster 10 Enrichment score: 9.02
GOTERM_BP_FAT Negative regulation of programmed cell death 38 8.4 6.92E-10 YWHAZ, HRAS, XIAP, ADORA2A, ERBB2, BCL2L1, KIT, PTEN, MIF, AKT1, IGF1R, CASP3, FNTA, ALB, BCL2, TGM2, GLO1, BCL6, TRAF6, PIK3CG, EGFR, ROCK1, BRAF, TGFBR1, PIM1, BIRC7, PRKCI, TP53, ESR1, IGF1, F7, ESR2, NME2, NME1, GSK3B, ADAM17, MAPK8, GSTP1, IL2 3.21 6.76E-08 1.26E-06
GOTERM_BP_FAT Negative regulation of cell death 38 8.14 7.49E-10 YWHAZ, HRAS, XIAP, ADORA2A, ERBB2, BCL2L1, KIT, PTEN, MIF, AKT1, IGF1R, CASP3, FNTA, ALB, BCL2, TGM2, GLO1, BCL6, TRAF6, PIK3CG, EGFR, ROCK1, BRAF, TGFBR1, PIM1, BIRC7, PRKCI, TP53, ESR1, IGF1, F7, ESR2, NME2, NME1, GSK3B, ADAM17, MAPK8, GSTP1, IL2 3.20 7.10E-08 1.36E-06
GOTERM_BP_FAT Negative regulation of apoptosis 37 7.92 1.71E-09 YWHAZ, HRAS, XIAP, ADORA2A, ERBB2, BCL2L1, PTEN, MIF, AKT1, IGF1R, CASP3, FNTA, ALB, BCL2, TGM2, GLO1, BCL6, TRAF6, EGFR, PIK3CG, ROCK1, BRAF, TGFBR1, PIM1, BIRC7, PRKCI, TP53, ESR1, IGF1, F7, ESR2, NME2, NME1, GSK3B, ADAM17, MAPK8, GSTP1, IL2 3.17 1.31E-07 3.11E-06
Annotation cluster 11 Enrichment score: 8.99
GOTERM_BP_FAT Positive regulation of apoptosis 42 8.99 8.49E-10 TRAF2, CDK5R1, ADORA2A, MMP-9, BCL2L1, CHEK2, SFN, NR3C1, PTEN, SRC, BTK, AKT1, VDR, APP, CASP3, TIAM1, PPP2CA, BCL2, CASP8, RAC1, TGM2, BCL6, RARB, CASP1, TRAF6, NQO1, PRKCA, PPP2R1A, NUDT2, RARG, TGFBR1, RXRA, TP53, CDK5, BRCA1, PLG, MAPK1, CD38, LCK, MAPK9, MAPK8, ABL1 2.96 7.82E-08 1.54E-06
GOTERM_BP_FAT Positive regulation of programmed cell death 42 8.99 1.05E-09 TRAF2, CDK5R1, ADORA2A, MMP-9, BCL2L1, CHEK2, SFN, NR3C1, PTEN, SRC, BTK, AKT1, VDR, APP, CASP3, TIAM1, PPP2CA, BCL2, CASP8, RAC1, TGM2, BCL6, RARB, CASP1, TRAF6, NQO1, PRKCA, PPP2R1A, NUDT2, RARG, TGFBR1, RXRA, TP53, CDK5, BRCA1, PLG, MAPK1, CD38, LCK, MAPK9, MAPK8, ABL1 2.94 8.87E-08 1.90E-06
GOTERM_BP_FAT Positive regulation of cell death 42 8.99 1.20E-09 TRAF2, CDK5R1, ADORA2A, MMP-9, BCL2L1, CHEK2, SFN, NR3C1, PTEN, SRC, BTK, AKT1, VDR, APP, CASP3, TIAM1, PPP2CA, BCL2, CASP8, RAC1, TGM2, BCL6, RARB, CASP1, TRAF6, NQO1, PRKCA, PPP2R1A, NUDT2, RARG, TGFBR1, RXRA, TP53, CDK5, BRCA1, PLG, MAPK1, CD38, LCK, MAPK9, MAPK8, ABL1 2.93 9.91E-08 2.18E-06
Annotation cluster 12 Enrichment score: 8.97
GOTERM_BP_FAT Regulation of cell motion 28 6.00 1.90E-10 NRP1, ERBB4, MMP-9, KIT, PTEN, AKT1, IGF1R, ACE, PTK2B, CXCR4, BCL2, TEK, RAC1, BCL6, INSR, EGFR, F10, LYN, MAP2K1, TGFBR1, IGF1, F7, CDK5, PLG, KDR, MAPK1, ADAM17, HDAC7 4.40 2.04E-08 3.45E-07
GOTERM_BP_FAT Regulation of locomotion 27 5.78 8.53E-10 ERBB4, ADORA2A, MMP-9, KIT, PTEN, AKT1, IGF1R, ACE, PTK2B, CXCR4, BCL2, TEK, RAC1, INSR, PRKCA, EGFR, F10, MAP2K1, ELANE, IGF1, F7, CDK5, PLG, KDR, MAPK1, ADAM17, HDAC7 4.27 7.64E-08 1.55E-06
GOTERM_BP_FAT Regulation of cell migration 24 5.14 7.40E-09 EGFR, F10, ERBB4, MAP2K1, MMP-9, IGF1, KIT, F7, CDK5, PTEN, PLG, KDR, AKT1, MAPK1, IGF1R, ACE, CXCR4, PTK2B, BCL2, TEK, RAC1, ADAM17, INSR, HDAC7 4.31 5.08E-07 1.34E-05
Annotation cluster 13 Enrichment score: 8.68
UP_SEQ_FEATURE GST N-terminal 12 2.57 4.56E-13 GSTM1, GSTA1, GSTM2, GSTA2, GSTA3, GSTA4, GSTZ1, GSTT1, GSTO2, GSTO1, HPGDS, GSTP1 23.39 5.74E-11 7.65E-10
INTERPRO Glutathione S-transferase, N-terminal 12 2.57 3.81E-12 GSTM1, GSTA1, GSTM2, GSTA2, GSTA3, GSTA4, GSTZ1, GSTT1, GSTO2, GSTO1, HPGDS, GSTP1 19.50 2.85E-10 5.94E-09
GOTERM_MF_FAT Glutathione transferase activity 12 2.57 9.51E-12 GSTM1, GSTA1, GSTM2, GSTA2, GSTA3, GSTA4, GSTK1, GSTZ1, GSTT1, GSTO2, GSTO1, GSTP1 17.31 4.47E-10 1.47E-08
UP_SEQ_FEATURE GST C-terminal 12 2.57 1.92E-10 GSTM1, GSTA1, GSTM2, GSTA2, GSTA3, GSTA4, GSTZ1, GSTT1, GSTO2, GSTO1, HPGDS, GSTP1 14.88 1.96E-08 3.22E-07
INTERPRO Glutathione S-transferase, C-terminal 10 2.14 2.08E-09 GSTM1, GSTA1, GSTM2, GSTA2, GSTA3, GSTA4, GSTZ1, GSTT1, GSTO1, GSTP1 17.02 1.17E-07 3.24E-06
INTERPRO Glutathione S-transferase, C-terminal-like 11 2.36 3.25E-09 GSTM1, GSTA1, GSTM2, GSTA2, GSTA3, GSTA4, GSTZ1, GSTT1, GSTO2, GSTO1, GSTP1 13.56 1.71E-07 5.06E-06
INTERPRO Glutathione S-transferase/chloride channel, C-terminal 11 2.36 4.75E-09 GSTM1, GSTA1, GSTM2, GSTA2, GSTA3, GSTA4, GSTZ1, GSTT1, GSTO2, GSTO1, GSTP1 13.11 2.37E-07 7.40E-06
KEGG_PATHWAY Glutathione metabolism 14 3.00 1.57E-05 GSTA1, GSTA2, ODC1, GSTA3, GSTA4, GSTT1, GSTM1, GSTM2, G6PD, GSTK1, GSTZ1, GSTO2, GSTO1, GSTP1 4.18 9.77E-05 0.018816
INTERPRO Thioredoxin fold 11 2.356 5.18E-04 GSTM1, GSTA1, GSTM2, GSTA2, GSTA3, GSTA4, GSTZ1, GSTT1, GSTO2, GSTO1, GSTP1 3.90 0.01217529 0.804529
Annotation cluster 14 Enrichment score: 7.42
GOTERM_BP_FAT Positive regulation of cell motion 19 4.07 2.63E-09 EGFR, F10, ERBB4, LYN, MAP2K1, MMP-9, TGFBR1, IGF1, KIT, F7, KDR, IGF1R, MAPK1, PTK2B, BCL2, ADAM17, BCL6, INSR, HDAC7 5.88 1.97E-07 4.77E-06
GOTERM_BP_FAT Positive regulation of locomotion 17 3.64 1.14E-07 PRKCA, EGFR, F10, ERBB4, MAP2K1, MMP-9, IGF1, F7, KIT, KDR, IGF1R, MAPK1, PTK2B, BCL2, ADAM17, INSR, HDAC7 5.26 5.58E-06 2.07E-04
GOTERM_BP_FAT Positive regulation of cell migration 16 3.43 1.85E-07 EGFR, F10, ERBB4, MAP2K1, MMP-9, IGF1, F7, KIT, KDR, IGF1R, MAPK1, PTK2B, BCL2, ADAM17, INSR, HDAC7 5.45 8.90E-06 3.36E-04
Annotation cluster 15 Enrichment score: 7.15
SP_PIR_KEYWORDS SH2 domain 17 3.64 1.08E-08 ITK, LYN, GRB2, HCK, SRC, PTPN11, BTK, TYK2, NCK2, DAPP1, FYN, LCK, ZAP70, JAK1, JAK3, ABL1, SYK 6.31 1.89E-07 1.56E-05
INTERPRO SH2 domain 17 3.64 7.50E-08 ITK, LYN, GRB2, HCK, SRC, PTPN11, BTK, TYK2, NCK2, DAPP1, FYN, LCK, ZAP70, JAK1, JAK3, ABL1, SYK 5.48 3.06E-06 1.17E-04
SMART SH2 domain 17 3.64 4.51E-07 ITK, LYN, GRB2, HCK, SRC, PTPN11, BTK, TYK2, NCK2, DAPP1, FYN, LCK, ZAP70, JAK1, JAK3, ABL1, SYK 4.75 1.26E-05 5.49E-04
Annotation cluster 16 Enrichment score: 7.12
GOTERM_BP_FAT Cell migration 31 6.64 8.87E-09 PPARD, CDK5R1, NRP1, HMGCR, PEX5, KIT, PTEN, SRC, PTK2, GAB2, CXCR4, PTK2B, PRSS3, RAC1, SFTPD, SYK, PRKCA, PLAT, RET, ROCK1, TGFBR1, MET, ELANE, ESR2, CDK5, KDR, NCK2, FYN, ADAM17, SDCBP, PLAU 3.41 5.84E-07 1.61E-05
GOTERM_BP_FAT Cell motility 31 6.64 9.98E-08 PPARD, CDK5R1, NRP1, HMGCR, PEX5, KIT, PTEN, SRC, PTK2, GAB2, CXCR4, PTK2B, PRSS3, RAC1, SFTPD, SYK, PRKCA, PLAT, RET, ROCK1, TGFBR1, MET, ELANE, ESR2, CDK5, KDR, NCK2, FYN, ADAM17, SDCBP, PLAU 3.06 4.95E-06 1.81E-04
GOTERM_BP_FAT Localization of cell 31 6.64 9.98E-08 PPARD, CDK5R1, NRP1, HMGCR, PEX5, KIT, PTEN, SRC, PTK2, GAB2, CXCR4, PTK2B, PRSS3, RAC1, SFTPD, SYK, PRKCA, PLAT, RET, ROCK1, TGFBR1, MET, ELANE, ESR2, CDK5, KDR, NCK2, FYN, ADAM17, SDCBP, PLAU 3.06 4.95E-06 1.81E-04
GOTERM_BP_FAT Cell motion 39 8.35 3.80E-07 ITGAL, PPARD, CDK5R1, NRP1, HMGCR, ERBB2, PEX5, KIT, PTEN, SRC, APP, PTK2, GAB2, CXCR4, PTK2B, PAK4, PRSS3, RAC1, SFTPD, SYK, PLAT, PRKCA, RET, MAP2K1, ROCK1, TGFBR1, ELANE, MET, IGF1, ESR2, CDK5, KDR, NCK2, FYN, MAPK14, ADAM17, SDCBP, MAPK8, PLAU 2.49 1.68E-05 6.90E-04
Annotation cluster 17 Enrichment score: 7.03
UP_SEQ_FEATURE Short sequence motif: cysteine switch 12 2.57 4.58E-09 MMP-20, MMP-9, MMP-8, MMP-7, ADAM17, MMP-16, MMP-3, MMP-13, ADAMTS5, MMP-12, MMP-1, ADAMTS4 11.42 4.41E-07 7.69E-06
INTERPRO Peptidase M, neutral zinc metallopeptidases, zinc- binding site 16 3.43 6.40E-08 MMP-9, MMP-8, MMP-7, MME, MMP-16, MMP-3, MMP-13, MMP-1, MMP-12, ACE, MMP-20, ECE1, ADAM17, LTA4H, ADAMTS5, ADAMTS4 5.96 2.74E-06 9.97E-05
GOTERM_MF_FAT Metalloendopeptidase activity 16 3.43 2.72E-06 SPG7, MMP-9, IDE, MMP-8, MMP-7, MME, MMP-16, MMP-3, MMP-13, MMP-1, MMP-12, MMP-20, ECE1, ADAM17, ADAMTS5, ADAMTS4 4.44 7.42E-05 0.004202
Annotation cluster 18 Enrichment score: 6.95
GOTERM_BP_FAT Positive regulation of kinase activity 27 5.78 4.35E-08 TRAF2, ADORA2A, ERBB2, KIT, AKT1, CDC42, PDPK1, PTK2B, CXCR4, MAP3K9, RAC1, PRKACA, PAK1, TRAF6, INSR, SYK, EGFR, MAP2K1, TGFBR1, MET, ELANE, BIRC7, PIM1, CDK5, PTPN11, ADAM17, IL2 3.55 2.46E-06 7.90E-05
GOTERM_BP_FAT Positive regulation of transferase activity 27 5.78 9.47E-08 TRAF2, ADORA2A, ERBB2, KIT, AKT1, CDC42, PDPK1, PTK2B, CXCR4, MAP3K9, RAC1, PRKACA, PAK1, TRAF6, INSR, SYK, EGFR, MAP2K1, TGFBR1, MET, ELANE, BIRC7, PIM1, CDK5, PTPN11, ADAM17, IL2 3.41 4.77E-06 1.72E-04
GOTERM_BP_FAT Positive regulation of protein kinase activity 25 5.35 3.34E-07 TRAF2, ADORA2A, ERBB2, KIT, AKT1, PDPK1, PTK2B, CXCR4, MAP3K9, PRKACA, PAK1, TRAF6, INSR, SYK, EGFR, MAP2K1, TGFBR1, MET, ELANE, BIRC7, PIM1, CDK5, PTPN11, ADAM17, IL2 3.40 1.49E-05 6.05E-04
Annotation cluster 19 Enrichment score: 6.74
GOTERM_BP_FAT Positive regulation of biosynthetic process 52 11.13 5.71E-08 HSP90AB1, PPARA, HRAS, THRA, THRB, PPARG, AKT1, APP, FNTA, RARB, KDM5A, DDAH1, INSR, AKT2, SYK, EGFR, AR, RARG, HSP90AA1, RXRA, ELANE, TP53, RB1, ESR2, PPARGC1A, CDK2, TNKS2, PRKCQ, MAPK1, NCOA1, NCOA2, F2, ADORA2A, ARNT, NR1H2, IGF1R, TNFRSF1A, PTK2B, TRAF6, NR1H4, NR1H3, BCKDHA, EPAS1, TGFBR1, ESRRG, IGF1, BRCA1, HDAC4, HDAC2, MAPK14, JAK3, IL2 2.27 3.07E-06 1.04E-04
GOTERM_BP_FAT Positive regulation of nitrogen compound metabolic process 49 10.49 9.00E-08 HSP90AB1, PPARA, NCBP1, HRAS, THRA, THRB, PPARG, AKT1, APP, RARB, KDM5A, DDAH1, INSR, EGFR, AR, RARG, HSP90AA1, RXRA, TP53, CD40, ESR2, RB1, PPARGC1A, CDK2, TNKS2, MAPK1, NCOA1, NCOA2, ADORA2A, COMT, HPRT1, ARNT, NR1H2, IGF1R, TNFRSF1A, NR1H4, NR1H3, BCKDHA, MAP2K1, EPAS1, TGFBR1, ESRRG, IGF1, BRCA1, HDAC4, HDAC2, MAPK14, JAK3, IL2 2.31 4.61E-06 1.63E-04
GOTERM_BP_FAT Positive regulation of cellular biosynthetic process 50 10.71 2.34E-07 HSP90AB1, PPARA, HRAS, THRA, THRB, PPARG, AKT1, APP, RARB, KDM5A, DDAH1, INSR, AKT2, SYK, EGFR, AR, RARG, HSP90AA1, RXRA, ELANE, TP53, RB1, ESR2, PPARGC1A, CDK2, TNKS2, PRKCQ, MAPK1, NCOA1, NCOA2, ADORA2A, ARNT, NR1H2, IGF1R, TNFRSF1A, PTK2B, TRAF6, NR1H4, NR1H3, BCKDHA, EPAS1, TGFBR1, ESRRG, IGF1, BRCA1, HDAC4, HDAC2, MAPK14, JAK3, IL2 2.21 1.11E-05 4.24E-04
GOTERM_BP_FAT Positive regulation of macromolecule biosynthetic process 47 10.06 9.04E-07 PPARA, HRAS, THRA, THRB, PPARG, ARNT, AKT1, NR1H2, IGF1R, TNFRSF1A, APP, FNTA, PTK2B, RARB, KDM5A, TRAF6, INSR, NR1H4, AKT2, SYK, NR1H3, BCKDHA, AR, RARG, EPAS1, TGFBR1, RXRA, ELANE, ESRRG, TP53, IGF1, RB1, ESR2, PPARGC1A, BRCA1, CDK2, TNKS2, HDAC4, MAPK1, PRKCQ, NCOA1, HDAC2, NCOA2, MAPK14, F2, JAK3, IL2 2.18 3.73E-05 0.001641
Annotation cluster 20 Enrichment score: 6.14
UP_SEQ_FEATURE AGC-kinase C-terminal 12 2.57 7.32E-08 PRKCA, AKT1, PRKCQ, SGK1, ROCK1, RPS6KA1, GRK6, PRKCI, PRKACA, ADRBK1, PRKCB, AKT2 8.93 5.99E-06 1.23E-04
INTERPRO AGC-kinase, C-terminal 12 2.57 2.81E-07 PRKCA, AKT1, PRKCQ, SGK1, ROCK1, RPS6KA1, GRK6, PRKCI, PRKACA, ADRBK1, PRKCB, AKT2 7.80 1.05E-05 4.38E-04
SMART S_TK_X 12 2.57 1.07E-06 PRKCA, AKT1, PRKCQ, SGK1, ROCK1, RPS6KA1, GRK6, PRKCI, PRKACA, ADRBK1, PRKCB, AKT2 6.76 2.25E-05 0.001302
INTERPRO Protein kinase, C-terminal 9 1.93 1.22E-05 PRKCA, AKT1, PRKCQ, SGK1, ROCK1, RPS6KA1, PRKCI, PRKCB, AKT2 8.04 3.31E-04 0.018952
Annotation cluster 21 Enrichment score: 5.96
INTERPRO 3′,5′-Cyclic nucleotide phosphodiesterase 9 1.93 5.13E-08 PDE2A, PDE7A, PDE4A, PDE4B, PDE5A, PDE3B, PDE9A, PDE4D, PDE8A 15.32 2.30E-06 8.00E-05
INTERPRO Metal-dependent phosphohydrolase, HD region 9 1.93 1.72E-07 PDE2A, PDE7A, PDE4A, PDE4B, PDE5A, PDE3B, PDE9A, PDE4D, PDE8A 13.41 6.73E-06 2.68E-04
UP_SEQ_FEATURE Metal ion-binding site: divalent metal cation 2 9 1.93 2.38E-07 PDE2A, PDE7A, PDE4A, PDE4B, PDE5A, PDE3B, PDE9A, PDE4D, PDE8A 13.16 1.86E-05 4.00E-04
UP_SEQ_FEATURE Metal ion-binding site: divalent metal cation 1 9 1.93 2.38E-07 PDE2A, PDE7A, PDE4A, PDE4B, PDE5A, PDE3B, PDE9A, PDE4D, PDE8A 13.16 1.86E-05 4.00E-04
SMART HDc 9 1.93 4.89E-07 PDE2A, PDE7A, PDE4A, PDE4B, PDE5A, PDE3B, PDE9A, PDE4D, PDE8A 11.62 1.17E-05 5.95E-04
GOTERM_MF_FAT 3′,5′-Cyclic-nucleotide phosphodiesterase activity 9 1.93 8.68E-07 PDE2A, PDE7A, PDE4A, PDE4B, PDE5A, PDE3B, PDE9A, PDE4D, PDE8A 10.82 2.53E-05 0.001342
GOTERM_MF_FAT Cyclic-nucleotide phosphodiesterase activity 9 1.93 1.24E-06 PDE2A, PDE7A, PDE4A, PDE4B, PDE5A, PDE3B, PDE9A, PDE4D, PDE8A 10.39 3.49E-05 0.001915
GOTERM_MF_FAT Phosphoric diester hydrolase activity 9 1.93 0.008435 PDE2A, PDE7A, PDE4A, PDE4B, PDE5A, PDE3B, PDE9A, PDE4D, PDE8A 3.09 0.08777958 12.27639
Annotation cluster 22 Enrichment score: 5.80
UP_SEQ_FEATURE Short sequence motif: cysteine switch 12 2.57 4.58E-09 MMP-20, MMP-9, MMP-8, MMP-7, ADAM17, MMP-16, MMP-3, MMP-13, ADAMTS5, MMP-12, MMP-1, ADAMTS4 11.42 4.41E-07 7.69E-06
INTERPRO Peptidoglycan binding like 9 1.93 3.26E-08 MMP-20, MMP-9, MMP-8, MMP-7, MMP-16, MMP-3, MMP-13, MMP-12, MMP-1 16.09 1.54E-06 5.07E-05
UP_SEQ_FEATURE Hemopexin-like 4 domain 8 1.71 6.08E-07 MMP-20, MMP-9, MMP-8, MMP-16, MMP-3, MMP-13, MMP-12, MMP-1 14.88 4.15E-05 0.001021
UP_SEQ_FEATURE Hemopexin-like 3 domain 8 1.71 6.08E-07 MMP-20, MMP-9, MMP-8, MMP-16, MMP-3, MMP-13, MMP-12, MMP-1 14.88 4.15E-05 0.001021
UP_SEQ_FEATURE Hemopexin-like 1 domain 8 1.71 8.56E-07 MMP-20, MMP-9, MMP-8, MMP-16, MMP-3, MMP-13, MMP-12, MMP-1 14.24 5.39E-05 0.001437
UP_SEQ_FEATURE Hemopexin-like 2 domain 8 1.71 8.56E-07 MMP-20, MMP-9, MMP-8, MMP-16, MMP-3, MMP-13, MMP-12, MMP-1 14.24 5.39E-05 0.001437
INTERPRO Peptidase, metallopeptidases 9 1.93 8.89E-07 MMP-20, MMP-9, MMP-8, MMP-7, MMP-16, MMP-3, MMP-13, MMP-12, MMP-1 11.09 3.07E-05 0.001385
INTERPRO Hemopexin/matrixin, repeat 8 1.71 2.10E-06 MMP-20, MMP-9, MMP-8, MMP-16, MMP-3, MMP-13, MMP-12, MMP-1 12.43 6.73E-05 0.003271
INTERPRO Hemopexin/matrixin, conserved site 8 1.71 2.10E-06 MMP-20, MMP-9, MMP-8, MMP-16, MMP-3, MMP-13, MMP-12, MMP-1 12.43 6.73E-05 0.003271
INTERPRO Hemopexin/matrixin 8 1.71 2.10E-06 MMP-20, MMP-9, MMP-8, MMP-16, MMP-3, MMP-13, MMP-12, MMP-1 12.43 6.73E-05 0.003271
INTERPRO Peptidase M10A and M12B, matrixin and adamalysin 10 2.14 2.31E-06 MMP-20, MMP-9, MMP-8, MMP-7, ADAM17, MMP-16, MMP-3, MMP-13, MMP-12, MMP-1 8.31 7.15E-05 0.003597
SMART ZnMc 9 1.93 2.48E-06 MMP-20, MMP-9, MMP-8, MMP-7, MMP-16, MMP-3, MMP-13, MMP-12, MMP-1 9.62 4.63E-05 0.003017
SMART HX 8 1.71 5.21E-06 MMP-20, MMP-9, MMP-8, MMP-16, MMP-3, MMP-13, MMP-12, MMP-1 10.78 8.76E-05 0.006349
INTERPRO Peptidase M10A, matrix metallopeotidase 7 1.50 6.39E-06 MMP-20, MMP-8, MMP-16, MMP-3, MMP-13, MMP-12, MMP-1 13.90 1.85E-04 0.009958
PIR_SUPERFAMILY Peptidase_M10A_matrix 7 1.50 1.06E-04 MMP-20, MMP-8, MMP-16, MMP-3, MMP-13, MMP-12, MMP-1 8.41 0.00874563 0.144244
PIR_SUPERFAMILY Matrix metalloproteinase, stromelysin type 6 1.28 2.87E-04 MMP-20, MMP-8, MMP-16, MMP-3, MMP-13, MMP-1 9.27 0.01875986 0.388252
Annotation cluster 23 Enrichment score: 5.73
UP_SEQ_FEATURE Metal ion-binding site: calcium 3; via carbonyl oxygen 8 1.71 4.23E-07 PRKCA, MMP-9, MMP-8, MMP-3, MMP-13, MMP-12, MMP-1, PRKCB 15.59 3.01E-05 7.11E-04
UP_SEQ_FEATURE Metal ion-binding site: calcium 1 10 2.14 1.15E-06 PRKCA, APCS, MMP-9, MMP-8, MMP-7, MMP-3, MMP-13, MMP-12, MMP-1, PRKCB 9.09 6.70E-05 0.001923
UP_SEQ_FEATURE Metal ion-binding site: calcium 2; via carbonyl oxygen 9 1.93 3.72E-06 PRKCA, MMP-9, MMP-8, MMP-7, MMP-3, MMP-13, MMP-12, MMP-1, PRKCB 9.44 1.90E-04 0.006252
UP_SEQ_FEATURE Metal ion-binding site: calcium 2 10 2.14 6.62E-06 PRKCA, APCS, MMP-9, MMP-8, MMP-7, MMP-3, MMP-13, MMP-12, MMP-1, PRKCB 7.44 3.19E-04 0.011118
Annotation cluster 24 Enrichment score: 5.69
UP_SEQ_FEATURE Metal ion-binding site: zinc 2; catalytic 8 1.71 1.45E-08 ACE, MMP-9, MMP-8, MMP-7, MMP-3, MMP-13, MMP-12, MMP-1 23.39 1.32E-06 2.43E-05
INTERPRO Peptidoglycan binding like 9 1.93 3.26E-08 MMP-20, MMP-9, MMP-8, MMP-7, MMP-16, MMP-3, MMP-13, MMP-12, MMP-1 16.09 1.54E-06 5.07E-05
UP_SEQ_FEATURE Metal ion-binding site: zinc 2; in inhibited form 7 1.50 3.93E-08 MMP-9, MMP-8, MMP-7, MMP-3, MMP-13, MMP-12, MMP-1 28.65 3.39E-06 6.60E-05
SP_PIR_KEYWORDS Metalloproteinase 9 1.93 5.85E-08 ACE, MMP-9, MMP-8, MMP-7, MME, MMP-3, MMP-13, MMP-12, MMP-1 15.45 9.65E-07 8.48E-05
INTERPRO Peptidase, metallopeptidases 9 1.93 8.89E-07 MMP-20, MMP-9, MMP-8, MMP-7, MMP-16, MMP-3, MMP-13, MMP-12, MMP-1 11.09 3.07E-05 0.001385
SP_PIR_KEYWORDS Collagen degradation 7 1.50 1.93E-06 MMP-9, MMP-8, MMP-7, MMP-16, MMP-3, MMP-13, MMP-1 16.96 2.43E-05 0.002803
SMART ZnMc 9 1.93 2.48E-06 MMP-20, MMP-9, MMP-8, MMP-7, MMP-16, MMP-3, MMP-13, MMP-12, MMP-1 9.62 4.63E-05 0.003017
GOTERM_BP_FAT Multicellular organismal catabolic process 8 1.71 1.52E-05 ACE, MMP-9, MMP-8, MMP-7, MMP-16, MMP-3, MMP-13, MMP-1 9.33 4.29E-04 0.027575
GOTERM_BP_FAT Collagen catabolic process 7 1.50 3.21E-05 MMP-9, MMP-8, MMP-7, MMP-16, MMP-3, MMP-13, MMP-1 10.62 7.95E-04 0.058172
GOTERM_BP_FAT Multicellular organismal macromolecule metabolic process 8 1.71 5.27E-05 ACE, MMP-9, MMP-8, MMP-7, MMP-16, MMP-3, MMP-13, MMP-1 7.83 0.00113118 0.095563
GOTERM_BP_FAT Multicellular organismal metabolic process 8 1.71 1.74E-04 ACE, MMP-9, MMP-8, MMP-7, MMP-16, MMP-3, MMP-13, MMP-1 6.56 0.0030583 0.315166
GOTERM_BP_FAT Collagen metabolic process 7 1.50 2.49E-04 MMP-9, MMP-8, MMP-7, MMP-16, MMP-3, MMP-13, MMP-1 7.58 0.00404851 0.451323
Annotation cluster 25 Enrichment score: 5.36
GOTERM_BP_FAT Hemopoiesis 24 5.14 3.31E-06 LYN, PLEK, EPAS1, MMP-9, PPARG, TP53, CDK6, RB1, KIT, KDR, ATP7A, HDAC4, CDC42, ACE, G6PD, BCL2, LCK, CASP8, ZAP70, ADAM17, BCL6, TRAF6, IL2, SYK 3.08 1.21E-04 0.006014
GOTERM_BP_FAT Immune system development 26 5.57 4.69E-06 MMP-9, UNG, PPARG, KIT, CDC42, ACE, BCL2, CASP8, ZAP70, BCL6, TRAF6, SYK, PLEK, LYN, EPAS1, TGFBR1, TP53, CDK6, RB1, KDR, ATP7A, HDAC4, G6PD, LCK, ADAM17, IL2 2.86 1.59E-04 0.00851
GOTERM_BP_FAT Hemopoietic or lymphoid organ development 25 5.35 5.23E-06 MMP-9, PPARG, KIT, CDC42, ACE, BCL2, CASP8, ZAP70, BCL6, TRAF6, SYK, PLEK, LYN, EPAS1, TGFBR1, TP53, CDK6, RB1, KDR, ATP7A, HDAC4, G6PD, LCK, ADAM17, IL2 2.92 1.74E-04 0.009499
Annotation cluster 26 Enrichment score: 5.32
GOTERM_BP_FAT Programmed cell death 44 9.42 2.08E-06 TRAF2, PPARD, HRAS, XIAP, ADORA2A, GJA1, BCL2L1, SFN, KIT, PTEN, AKT1, TNFRSF1A, APP, CASP3, ECE1, CXCR4, TIAM1, PTK2B, CASP7, BCL2, RAC1, CASP8, TGM2, PAK1, TRAF6, CASP1, SGK1, ROCK1, GZMA, LGALS1, TP53, BIRC7, RAF1, GZMB, CDK5, BRCA1, PLG, NAE1, VCP, F2, LCK, MAPK8, MDM4, PDCD6IP 2.18 7.88E-05 0.003772
GOTERM_BP_FAT Cell death 48 10.28 5.10E-06 TRAF2, PPARD, HRAS, SPG7, XIAP, ADORA2A, GJA1, BCL2L1, SFN, KIT, HPRT1, PTEN, AKT1, TNFRSF1A, APP, CASP3, ECE1, CXCR4, TIAM1, PTK2B, CASP7, BCL2, RAC1, CASP8, TGM2, PAK1, TRAF6, CASP1, AR, SGK1, ROCK1, GZMA, LGALS1, TP53, BIRC7, RAF1, GZMB, CDK5, BRCA1, PLG, NAE1, VCP, LCK, F2, CTSD, MAPK8, MDM4, PDCD6IP 2.02 1.71E-04 0.009255
GOTERM_BP_FAT Death 48 10.28 6.06E-06 TRAF2, PPARD, HRAS, SPG7, XIAP, ADORA2A, GJA1, BCL2L1, SFN, KIT, HPRT1, PTEN, AKT1, TNFRSF1A, APP, CASP3, ECE1, CXCR4, TIAM1, PTK2B, CASP7, BCL2, RAC1, CASP8, TGM2, PAK1, TRAF6, CASP1, AR, SGK1, ROCK1, GZMA, LGALS1, TP53, BIRC7, RAF1, GZMB, CDK5, BRCA1, PLG, NAE1, VCP, LCK, F2, CTSD, MAPK8, MDM4, PDCD6IP 2.01 1.95E-04 0.011004
GOTERM_BP_FAT Apoptosis 42 8.99 8.02E-06 TRAF2, PPARD, HRAS, XIAP, ADORA2A, GJA1, BCL2L1, SFN, PTEN, AKT1, TNFRSF1A, APP, CASP3, ECE1, CXCR4, TIAM1, PTK2B, CASP7, BCL2, RAC1, CASP8, PAK1, CASP1, TRAF6, SGK1, ROCK1, GZMA, LGALS1, TP53, BIRC7, RAF1, GZMB, CDK5, BRCA1, PLG, NAE1, VCP, F2, LCK, MAPK8, MDM4, PDCD6IP 2.12 2.46E-04 0.014551
Annotation cluster 27 Enrichment score: 5.27
GOTERM_BP_FAT Glucose metabolic process 20 4.28 6.48E-07 PDK1, RBP4, PPARD, ALDH5A1, PDK3, PDK4, FBP1, DLAT, PPP1CC, PPARGC1A, PDHB, PCK1, AKT1, PPP1CA, TPI1, G6PD, PYGL, MAPK14, GSK3B, PDHA1 3.96 2.75E-05 0.001176
GOTERM_BP_FAT Hexose metabolic process 21 4.50 5.31E-06 PDK1, RBP4, PPARD, ALDH5A1, PDK3, PDK4, FBP1, DLAT, PPP1CC, PPARGC1A, PDHB, PCK1, AKT1, KHK, PPP1CA, TPI1, G6PD, PYGL, MAPK14, GSK3B, PDHA1 3.32 1.75E-04 0.009641
GOTERM_BP_FAT Monosaccharide metabolic process 21 4.50 4.51E-05 PDK1, RBP4, PPARD, ALDH5A1, PDK3, PDK4, FBP1, DLAT, PPP1CC, PPARGC1A, PDHB, PCK1, AKT1, KHK, PPP1CA, TPI1, G6PD, PYGL, MAPK14, GSK3B, PDHA1 2.87 9.94E-04 0.081769
Annotation cluster 28 Enrichment score: 4.77
UP_SEQ_FEATURE Short sequence motif: TXY 6 1.28 5.80E-06 MAPK1, MAPK14, MAPK3, MAPK9, MAPK8, MAPK10 20.46 2.88E-04 0.009734
INTERPRO MAP kinase, conserved site 6 1.28 1.12E-05 MAPK1, MAPK14, MAPK3, MAPK9, MAPK8, MAPK10 17.87 3.13E-04 0.017402
GOTERM_MF_FAT MAP kinase activity 6 1.28 7.48E-05 MAPK1, MAPK14, MAPK3, MAPK9, MAPK8, MAPK10 12.36 0.00154179 0.11556
Annotation cluster 29 Enrichment score: 4.76
GOTERM_BP_FAT Blood coagulation 15 3.21 5.98E-06 PLAT, F11, F10, PLEK, ADORA2A, F8, F9, CD40, F7, PLG, LPA, SERPINE1, F2, SERPINC1, PLAU 4.46 1.95E-04 0.01085
GOTERM_BP_FAT Coagulation 15 3.21 5.98E-06 PLAT, F11, F10, PLEK, ADORA2A, F8, F9, CD40, F7, PLG, LPA, SERPINE1, F2, SERPINC1, PLAU 4.46 1.95E-04 0.01085
GOTERM_BP_FAT Hemostasis 15 3.21 1.17E-05 PLAT, F11, F10, PLEK, ADORA2A, F8, F9, CD40, F7, PLG, LPA, SERPINE1, F2, SERPINC1, PLAU 4.21 3.47E-04 0.021303
GOTERM_BP_FAT Regulation of body fluid levels 15 3.21 2.26E-04 PLAT, F11, F10, PLEK, ADORA2A, F8, F9, CD40, F7, PLG, LPA, SERPINE1, F2, SERPINC1, PLAU 3.23 0.00375601 0.410281
Annotation cluster 30 Enrichment score: 4.68
UP_SEQ_FEATURE Region of interest: S-adenosyl-L-methionine binding 9 1.93 1.55E-06 EHMT1, PNMT, METTL1, SETD8, GAMT, COMT, GNMT, EHMT2, NNMT 10.52 8.76E-05 0.002605
UP_SEQ_FEATURE Binding site: S-adenosyl-L- methionine 10 2.14 3.45E-06 EHMT1, HNMT, PNMT, SETD8, GAMT, COMT, GNMT, EHMT2, TPMT, NNMT 8.02 1.82E-04 0.005799
SP_PIR_KEYWORDS S-Adenosyl-L-methionine 12 2.57 4.03E-05 EHMT1, HNMT, PNMT, METTL1, SETD8, GAMT, COMT, GNMT, EHMT2, AMD1, TPMT, NNMT 4.80 3.49E-04 0.05845
SP_PIR_KEYWORDS Methyltransferase 12 2.57 8.74E-04 TYMS, EHMT1, HNMT, PNMT, METTL1, SETD8, GAMT, COMT, GNMT, EHMT2, TPMT, NNMT 3.39 0.00613378 1.260168
Annotation cluster 31 Enrichment score: 4.64
GOTERM_BP_FAT Regulation of carbohydrate metabolic process 10 2.14 3.66E-06 AKT1, HDAC4, PLEK, IGF1, NR3C1, INSR, PPARGC1A, NR1H4, ARNT, AKT2 7.78 1.31E-04 0.006647
GOTERM_BP_FAT Regulation of cellular carbohydrate metabolic process 9 1.93 2.64E-05 AKT1, HDAC4, PLEK, IGF1, NR3C1, INSR, PPARGC1A, ARNT, AKT2 7.18 6.86E-04 0.047923
GOTERM_BP_FAT Regulation of glucose metabolic process 8 1.71 1.20E-04 AKT1, HDAC4, IGF1, NR3C1, INSR, PPARGC1A, ARNT, AKT2 6.93 0.00225032 0.21798
Annotation cluster 32 Enrichment score: 4.32
SP_PIR_KEYWORDS Zinc 98 20.99 2.10E-09 THRA, THRB, S100A7, MMP-9, IDE, MMP-8, MMP-7, ADH1C, ADH1B, ADH1A, MMP-3, MMP-1, BTK, PGR, FNTB, HMHA1, APP, ASPA, RARB, CPA1, DDAH1, NQO2, RARG, ROCK1, BRAF, RXRA, UBR2, PPP1CC, PPP1CA, PYGO1, ADAMTS5, ADAMTS4, TRAF2, MME, NR1H2, VDR, ACE, ECE1, ALB, CDA, GLO1, TRAF6, NR1H4, NR1H3, CPA4, ITK, EHMT1, ESRRG, EHMT2, BRCA1, NR1I3, NR1I2, S100B, AIRE, HGS, PARP1, CPB2, PPARA, SPG7, PPARD, PPARG, ZCWPW1, MMP-20, KDM5A, PRKCA, AR, TP53, PRKCI, ESR1, MMP-16, ESR2, MMP-13, MMP-12, PRKCB, PRKCQ, FOLH1, NAALAD2, CA4, ADAM17, MDM2, PDE9A, MDM4, CA2, CA1, XIAP, CA13, ADH5, ADH7, EEA1, NR3C1, ADH4, PPP2CA, BCL6, L3MBTL2, BIRC7, SIRT5, RAF1, QPCT, LTA4H, KDM4A 1.84 4.10E-08 3.04E-06
GOTERM_MF_FAT Transition metal ion binding 123 26.34 0.00201 THRA, THRB, S100A7, MMP-9, IDE, MMP-8, ADH1C, MMP-7, ADH1B, ADH1A, MMP-3, MMP-1, BTK, PGR, FNTB, HMHA1, APP, ASPA, FNTA, MAT1A, CPA1, RARB, DDAH1, NQO2, RARG, ROCK1, BRAF, RXRA, PIM1, F8, UBR2, PPP1CC, POR, PPP1CA, PDE5A, PYGO1, ADAMTS5, ADAMTS4, XDH, TRAF2, MME, NR1H2, ARG1, VDR, ACE, ECE1, ALB, ARG2, PIR, CDA, GLO1, TRAF6, NR1H4, NR1H3, ITK, CPA4, EHMT1, TGFBR1, ESRRG, ACACB, EHMT2, BRCA1, GART, ATP7A, HDAC4, NR1I3, NR1I2, S100B, AIRE, HGS, PTPN1, PARP1, ABL1, CPB2, ABO, PPARA, PPARD, SPG7, METAP1, METAP2, PPARG, ZCWPW1, MMP-20, HIF1AN, PDE8A, KDM5A, PRKCA, AR, ESR1, PRKCI, TP53, MMP-16, ESR2, MMP-13, MMP-12, PRKCB, PRKCQ, FOLH1, NAALAD2, ADAM17, CA4, MDM2, PDE9A, CA2, MDM4, CA1, TPH1, XIAP, CA13, ADH5, EEA1, ADH7, NR3C1, ADH4, PPP2CA, BCL6, L3MBTL2, BIRC7, SIRT5, RAF1, PCK1, QPCT, FYN, LTA4H, KDM4A 1.27 0.02584329 3.062766
GOTERM_MF_FAT Zinc ion binding 97 20.77 0.026629 THRA, THRB, S100A7, MMP-9, IDE, MMP-8, MMP-7, ADH1C, ADH1B, ADH1A, MMP-3, MMP-1, BTK, PGR, FNTB, HMHA1, APP, ASPA, FNTA, RARB, CPA1, DDAH1, NQO2, RARG, ROCK1, BRAF, RXRA, UBR2, PDE5A, PYGO1, ADAMTS5, ADAMTS4, TRAF2, MME, NR1H2, VDR, ACE, ECE1, CDA, GLO1, TRAF6, NR1H4, NR1H3, CPA4, ITK, EHMT1, ESRRG, EHMT2, BRCA1, HDAC4, NR1I3, NR1I2, S100B, AIRE, HGS, PTPN1, PARP1, CPB2, PPARA, SPG7, PPARD, PPARG, ZCWPW1, MMP- 20, KDM5A, PRKCA, AR, TP53, PRKCI, ESR1, MMP-16, ESR2, MMP-13, MMP-12, PRKCB, PRKCQ, FOLH1, NAALAD2, CA4, ADAM17, MDM2, MDM4, CA2, CA1, XIAP, CA13, ADH5, ADH7, EEA1, NR3C1, ADH4, BCL6, L3MBTL2, BIRC7, SIRT5, RAF1, QPCT, LTA4H, KDM4A 1.21 0.19883278 34.1204
Annotation cluster 33 Enrichment score: 4.22
GOTERM_BP_FAT Phenol metabolic process 9 1.93 1.39E-05 ATP7A, PNMT, EPAS1, SULT1B1, MAOA, SULT1A1, SULT1A2, COMT, HPRT1 7.80 3.95E-04 0.025154
GOTERM_BP_FAT Diol metabolic process 8 1.71 9.89E-05 ATP7A, PNMT, EPAS1, MAOA, SULT1A1, SULT1A2, COMT, HPRT1 7.14 0.00196673 0.179443
GOTERM_BP_FAT Catechol metabolic process 8 1.71 9.89E-05 ATP7A, PNMT, EPAS1, MAOA, SULT1A1, SULT1A2, COMT, HPRT1 7.14 0.00196673 0.179443
GOTERM_BP_FAT Catecholamine metabolic process 8 1.71 9.89E-05 ATP7A, PNMT, EPAS1, MAOA, SULT1A1, SULT1A2, COMT, HPRT1 7.14 0.00196673 0.179443
Annotation cluster 34 Enrichment score: 4.16
PIR_SUPERFAMILY Alcohol sulfotransferase 7 1.50 1.65E-06 SULT2A1, SULT1B1, SULT1A1, SULT1A2, SULT1C2, SULT1E1, SULT1C3 15.14 1.82E-04 0.002238
UP_SEQ_FEATURE Nucleotide phosphate- binding region: PAPS 8 1.71 9.72E-06 SULT2A1, SULT1B1, SULT1A1, SULT2B1, SULT1A2, SULT1C2, SULT1E1, SULT1C3 10.23 4.54E-04 0.016313
INTERPRO Sulfotransferase 8 1.71 1.86E-05 SULT2A1, SULT1B1, SULT1A1, SULT2B1, SULT1A2, SULT1C2, SULT1E1, SULT1C3 9.23 4.90E-04 0.028912
GOTERM_MF_FAT Sulfotransferase activity 8 1.71 0.00138 SULT2A1, SULT1B1, SULT1A1, SULT2B1, SULT1A2, SULT1C2, SULT1E1, SULT1C3 4.71 0.01896331 2.111955
GOTERM_MF_FAT Transferase activity, transferring sulfur- containing groups 8 1.71 0.0037 SULT2A1, SULT1B1, SULT1A1, SULT2B1, SULT1A2, SULT1C2, SULT1E1, SULT1C3 3.98 0.04321176 5.571159
Annotation cluster 35 Enrichment score: 4.11
GOTERM_BP_FAT Protein complex assembly 36 7.71 2.61E-05 HSD17B10, TRAF2, HRAS, GRB2, IDE, GJA1, PEX5, FKBP1A, HPRT1, SRC, MIF, TNFRSF1A, IGF1R, PTK2, PTK2B, RAC1, CASP8, TGM2, CDA, GNMT, INSR, SYK, PPP2R1A, HSP90AA1, APCS, MAP2K1, BRAF, ALDH5A1, TP53, CD40, CDK5, PPARGC1A, NCK2, VCP, MDM2, MDM4 2.16 6.89E-04 0.047358
GOTERM_BP_FAT Protein complex biogenesis 36 7.71 2.61E-05 HSD17B10, TRAF2, HRAS, GRB2, IDE, GJA1, PEX5, FKBP1A, HPRT1, SRC, MIF, TNFRSF1A, IGF1R, PTK2, PTK2B, RAC1, CASP8, TGM2, CDA, GNMT, INSR, SYK, PPP2R1A, HSP90AA1, APCS, MAP2K1, BRAF, ALDH5A1, TP53, CD40, CDK5, PPARGC1A, NCK2, VCP, MDM2, MDM4 2.16 6.89E-04 0.047358
GOTERM_BP_FAT Macromolecular complex assembly 41 8.78 1.65E-04 NCBP2, HSD17B10, TRAF2, NCBP1, HRAS, GRB2, IDE, GJA1, PEX5, FKBP1A, HPRT1, SRC, MIF, IGF1R, TNFRSF1A, PTK2, HIST1H4A, PTK2B, RAC1, CASP8, TGM2, CDA, GNMT, INSR, SYK, PPP2R1A, HSP90AA1, APCS, MAP2K1, BRAF, ALDH5A1, SNUPN, TP53, CD40, CDK5, PPARGC1A, NCK2, VCP, HIST1H3A, MDM2, MDM4, HIST1H3G 1.87 0.00291459 0.298718
GOTERM_BP_FAT Macromolecular complex subunit organization 42 9.00 3.20E-04 NCBP2, HSD17B10, NCBP1, TRAF2, HRAS, GRB2, IDE, GJA1, PEX5, FKBP1A, HPRT1, SRC, MIF, IGF1R, TNFRSF1A, PTK2, HIST1H4A, PTK2B, RAC1, CASP8, TGM2, CDA, GNMT, INSR, SYK, PPP2R1A, HSP90AA1, APCS, MAP2K1, BRAF, ALDH5A1, SNUPN, TP53, CD40, CDK5, PPARGC1A, NCK2, VCP, HIST1H3A, PLA2G2A, MDM2, MDM4, HIST1H3G 1.79 0.0048243 0.578406
Annotation cluster 36 Enrichment score: 4.00
GOTERM_BP_FAT Regulation of cell activation 18 3.85 6.55E-05 TRAF2, PLEK, ADORA2A, ERBB2, CD40, PNP, MIF, CD38, PRKCQ, NCK2, CASP3, LCK, SFTPD, ZAP70, BCL6, TRAF6, SYK, IL2 3.12 0.00136967 0.118797
GOTERM_BP_FAT Regulation of lymphocyte activation 16 3.43 1.08E-04 TRAF2, ADORA2A, ERBB2, CD40, PNP, PRKCQ, NCK2, CD38, CASP3, LCK, SFTPD, ZAP70, BCL6, TRAF6, SYK, IL2 3.28 0.00208753 0.196338
GOTERM_BP_FAT Regulation of leukocyte activation 17 3.64 1.17E-04 TRAF2, ADORA2A, ERBB2, CD40, PNP, MIF, PRKCQ, NCK2, CD38, CASP3, LCK, SFTPD, ZAP70, BCL6, TRAF6, SYK, IL2 3.11 0.00220533 0.212381
GOTERM_BP_FAT Regulation of T-cell activation 14 3.00 1.22E-04 TRAF2, ADORA2A, ERBB2, PNP, PRKCQ, NCK2, CASP3, LCK, SFTPD, ZAP70, BCL6, TRAF6, SYK, IL2 3.63 0.0022739 0.221543
Annotation cluster 37 Enrichment score: 3.97
GOTERM_BP_FAT Positive regulation of phosphorylation 13 2.78 7.83E-05 EGFR, PRKCA, LYN, TGFBR1, IGF1, TTK, BCL2, F2, ADAM17, TNK2, INSR, SYK, IL2 4.07 0.00161717 0.142086
GOTERM_BP_FAT Positive regulation of phosphate metabolic process 13 2.78 1.06E-04 EGFR, PRKCA, LYN, TGFBR1, IGF1, TTK, BCL2, F2, ADAM17, TNK2, INSR, SYK, IL2 3.94 0.00206093 0.191517
GOTERM_BP_FAT Positive regulation of phosphorus metabolic process 13 2.78 1.06E-04 EGFR, PRKCA, LYN, TGFBR1, IGF1, TTK, BCL2, F2, ADAM17, TNK2, INSR, SYK, IL2 3.94 0.00206093 0.191517
GOTERM_BP_FAT Positive regulation of protein amino acid phosphorylation 12 2.57 1.56E-04 PRKCA, LYN, BCL2, TGFBR1, F2, ADAM17, IGF1, TTK, TNK2, INSR, IL2, SYK 4.09 0.00277529 0.282881
Annotation cluster 38 Enrichment score: 3.85
GOTERM_BP_FAT Regulation of establishment of protein localization 15 3.21 4.31E-05 RBP4, ADORA2A, TGFBR1, PRKCI, CD40, CDK5, PTPN11, AKT1, PRKCQ, PDPK1, GSK3B, PRKACA, TRAF6, CASP1, IL2 3.76 9.64E-04 0.078194
GOTERM_BP_FAT Regulation of protein localization 16 3.43 4.84E-05 RBP4, ADORA2A, TGFBR1, PRKCI, CD40, CDK5, PTPN11, AKT1, PRKCQ, PDPK1, GSK3B, BCL2, PRKACA, TRAF6, CASP1, IL2 3.52 0.00105367 0.087828
GOTERM_BP_FAT Regulation of protein transport 12 2.57 0.00132 PRKCQ, RBP4, ADORA2A, GSK3B, TGFBR1, PRKACA, CD40, TRAF6, CASP1, CDK5, IL2, PTPN11 3.19 0.0157027 2.369144
Annotation cluster 39 Enrichment score: 3.73
INTERPRO EGF receptor, L domain 5 1.07 1.96E-05 EGFR, IGF1R, ERBB4, ERBB2, INSR 25.53 5.03E-04 0.030568
INTERPRO Furin-like cysteine-rich region 5 1.07 1.96E-05 EGFR, IGF1R, ERBB4, ERBB2, INSR 25.53 5.03E-04 0.030568
INTERPRO Furin-like repeat 5 1.07 0.001343 EGFR, IGF1R, ERBB4, ERBB2, INSR 9.93 0.02767984 2.072751
SMART FU 5 1.07 0.002245 EGFR, IGF1R, ERBB4, ERBB2, INSR 8.61 0.03373603 2.698772
Annotation cluster 40 Enrichment score: 3.73
GOTERM_BP_FAT Cell projection organization 30 6.42 1.26E-05 FGFR1, CDK5R1, NRP1, ADORA2A, ERBB2, GJA1, HPRT1, PTEN, AKT1, CDC42, IGF1R, APP, PTK2, CXCR4, PTK2B, BCL2, RAC1, CDH23, EGFR, PRKCA, MAP2K1, ROCK1, PLEK, RXRA, CDK5, PTPN11, ATP7A, NCK2, S100B, SDCBP 2.47 3.66E-04 0.022889
GOTERM_BP_FAT Neuron projection development 23 4.93 3.91E-05 PRKCA, EGFR, FGFR1, CDK5R1, NRP1, MAP2K1, ADORA2A, RXRA, ERBB2, GJA1, HPRT1, CDK5, PTEN, PTPN11, ATP7A, IGF1R, PTK2, APP, S100B, CXCR4, PTK2B, BCL2, RAC1 2.73 9.07E-04 0.070998
GOTERM_BP_FAT Neuron projection morphogenesis 20 4.28 7.95E-05 PRKCA, EGFR, CDK5R1, NRP1, MAP2K1, ADORA2A, RXRA, ERBB2, GJA1, HPRT1, CDK5, PTPN11, ATP7A, IGF1R, PTK2, APP, S100B, CXCR4, BCL2, RAC1 2.85 0.00163049 0.144174
GOTERM_BP_FAT Neuron development 26 5.57 1.45E-04 FGFR1, CDK5R1, NRP1, ADORA2A, ERBB2, GJA1, HPRT1, PTEN, IGF1R, APP, PTK2, PTK2B, CXCR4, BCL2, RAC1, CDH23, EGFR, PRKCA, RET, MAP2K1, RXRA, PRKCI, CDK5, PTPN11, ATP7A, S100B 2.33 0.00262906 0.26354
GOTERM_BP_FAT Neuron differentiation 30 6.42 2.81E-04 FGFR1, CDK5R1, NRP1, ADORA2A, ERBB2, GJA1, PEX5, HPRT1, PTEN, CDC42, IGF1R, APP, PTK2, CXCR4, PTK2B, BCL2, RAC1, CDH23, EGFR, PRKCA, RET, MAP2K1, RXRA, TGFBR1, PRKCI, CDK5, PTPN11, ATP7A, PRKCQ, S100B 2.08 0.00445775 0.50945
GOTERM_BP_FAT Cell morphogenesis 26 5.57 3.08E-04 CDK5R1, NRP1, ADORA2A, ERBB2, GJA1, HPRT1, IGF1R, CDC42, APP, PTK2, CXCR4, BCL2, RAC1, BCL6, DLG1, CDH23, EGFR, PRKCA, MAP2K1, RXRA, PRKCI, CDK5, PTPN11, ATP7A, S100B, ERBB2IP 2.22 0.00471944 0.557892
GOTERM_BP_FAT Cell projection morphogenesis 20 4.28 4.83E-04 PRKCA, EGFR, CDK5R1, NRP1, MAP2K1, ADORA2A, RXRA, ERBB2, GJA1, HPRT1, CDK5, PTPN11, ATP7A, IGF1R, PTK2, APP, S100B, CXCR4, BCL2, RAC1 2.48 0.00684232 0.873863
GOTERM_BP_FAT Cell part morphogenesis 20 4.28 8.26E-04 PRKCA, EGFR, CDK5R1, NRP1, MAP2K1, ADORA2A, RXRA, ERBB2, GJA1, HPRT1, CDK5, PTPN11, ATP7A, IGF1R, PTK2, APP, S100B, CXCR4, BCL2, RAC1 2.37 0.01076448 1.488171
GOTERM_BP_FAT Cellular component morphogenesis 26 5.57 0.001471 CDK5R1, NRP1, ADORA2A, ERBB2, GJA1, HPRT1, IGF1R, CDC42, APP, PTK2, CXCR4, BCL2, RAC1, BCL6, DLG1, CDH23, EGFR, PRKCA, MAP2K1, RXRA, PRKCI, CDK5, PTPN11, ATP7A, S100B, ERBB2IP 1.99 0.01716579 2.636383
Annotation cluster 41 Enrichment score: 3.64
GOTERM_CC_FAT Membrane-enclosed lumen 83 17.77 9.64E-05 NCBP2, NCBP1, TSG101, IDE, PEX5, XRCC1, AGXT, C1QC, PDHB, AKT1, KDM1A, PARN, APP, CASP3, CSNK2A1, CASP7, CASP8, PDHA1, BRD4, CFD, KDM5A, RARG, LYN, GATM, TP53, F8, TLE1, RB1, PPP1CC, PPARGC1A, WEE1, CDK2, MAPK1, PNKP, PPP1CA, MAPK3, MDM2, MAPK8, ME2, NEK2, FARS2, CHEK1, KIT, NR3C1, CHEK2, HIST1H4A, BCHE, ALB, MDC1, GSTK1, NUDT21, HSD17B4, PDK1, BCKDHA, DHX9, KAT2B, CES1, EPAS1, PDK3, PDK4, BCKDHB, IGF1, SIRT5, DLAT, NXF1, BRCA1, PCK1, HDAC4, DUSP3, HDAC2, RPS6KA1, VCP, PLK1, MAPK14, DYRK1A, ALDH2, KDM4A, ABL1, PARP1, PARP2, HDAC8, HDAC7, UBE2E1 1.50 0.00321839 0.13268
GOTERM_CC_FAT Organelle lumen 81 17.34 1.45E-04 NCBP2, NCBP1, TSG101, IDE, PEX5, XRCC1, AGXT, C1QC, PDHB, AKT1, KDM1A, PARN, APP, CASP3, CSNK2A1, CASP7, CASP8, PDHA1, BRD4, CFD, KDM5A, RARG, TP53, F8, TLE1, RB1, PPP1CC, PPARGC1A, WEE1, CDK2, MAPK1, PNKP, PPP1CA, MAPK3, MDM2, MAPK8, ME2, NEK2, FARS2, CHEK1, KIT, NR3C1, CHEK2, HIST1H4A, BCHE, ALB, MDC1, GSTK1, NUDT21, HSD17B4, PDK1, BCKDHA, DHX9, KAT2B, CES1, EPAS1, PDK3, PDK4, BCKDHB, IGF1, SIRT5, DLAT, NXF1, BRCA1, PCK1, HDAC4, DUSP3, HDAC2, RPS6KA1, VCP, PLK1, MAPK14, DYRK1A, ALDH2, KDM4A, ABL1, PARP1, PARP2, HDAC8, HDAC7, UBE2E1 1.50 0.00410352 0.199949
GOTERM_CC_FAT Intracellular organelle lumen 76 16.27 8.68E-04 NCBP2, NCBP1, TSG101, IDE, PEX5, XRCC1, AGXT, C1QC, PDHB, AKT1, KDM1A, PARN, CASP3, CSNK2A1, CASP7, CASP8, PDHA1, BRD4, KDM5A, RARG, TP53, TLE1, RB1, PPP1CC, PPARGC1A, WEE1, CDK2, MAPK1, PNKP, PPP1CA, MAPK3, MDM2, MAPK8, ME2, NEK2, FARS2, CHEK1, NR3C1, KIT, CHEK2, HIST1H4A, BCHE, MDC1, GSTK1, NUDT21, HSD17B4, PDK1, BCKDHA, DHX9, KAT2B, CES1, EPAS1, PDK3, PDK4, BCKDHB, SIRT5, DLAT, NXF1, BRCA1, PCK1, HDAC4, DUSP3, HDAC2, RPS6KA1, VCP, PLK1, MAPK14, DYRK1A, ALDH2, KDM4A, ABL1, PARP1, PARP2, HDAC8, HDAC7, UBE2E1 1.44 0.01759311 1.189132
Annotation cluster 42 Enrichment score: 3.60
GOTERM_BP_FAT Negative regulation of macromolecule biosynthetic process 36 7.71 1.32E-04 PPARA, PPARD, THRA, THRB, TSG101, PPARG, NR1H2, KDM1A, VDR, FNTA, EED, SFTPD, BCL6, RARB, NR1H4, PRKCA, RARG, EHMT1, RXRA, ELANE, TP53, SIRT5, TLE1, RB1, BRCA1, HDAC4, NR1I2, NCOA2, HDAC2, BACE2, UBA3, MDM2, FABP4, SETD8, MDM4, HDAC8 2.00 0.00243752 0.238856
GOTERM_BP_FAT Negative regulation of gene expression 34 7.28 1.33E-04 PPARA, PPARD, THRA, THRB, TSG101, PPARG, BCL2L1, NR1H2, KDM1A, VDR, SND1, EED, BCL6, RARB, INSR, NR1H4, RARG, EHMT1, RXRA, TP53, SIRT5, TLE1, RB1, BRCA1, HDAC4, NCOA2, HDAC2, NR1I2, UBA3, MDM2, FABP4, SETD8, MDM4, HDAC8 2.05 0.00244468 0.240933
GOTERM_BP_FAT Negative regulation of biosynthetic process 37 7.92 1.53E-04 PPARA, PPARD, THRA, THRB, TSG101, PPARG, NR1H2, KDM1A, VDR, FNTA, EED, SFTPD, BCL6, RARB, NR1H4, PRKCA, RARG, EHMT1, PLEK, RXRA, ELANE, TP53, SIRT5, TLE1, RB1, BRCA1, HDAC4, NR1I2, NCOA2, HDAC2, BACE2, UBA3, MDM2, FABP4, SETD8, MDM4, HDAC8 1.96 0.00272817 0.276544
GOTERM_BP_FAT Negative regulation of cellular biosynthetic process 36 7.71 2.14E-04 PPARA, PPARD, THRA, THRB, TSG101, PPARG, NR1H2, KDM1A, VDR, EED, SFTPD, BCL6, RARB, NR1H4, PRKCA, RARG, EHMT1, PLEK, RXRA, ELANE, TP53, SIRT5, TLE1, RB1, BRCA1, HDAC4, NR1I2, NCOA2, HDAC2, BACE2, UBA3, MDM2, FABP4, SETD8, MDM4, HDAC8 1.95 0.00359443 0.388594
GOTERM_BP_FAT Negative regulation of transcription 31 6.64 2.76E-04 PPARA, PPARD, THRA, THRB, TSG101, PPARG, NR1H2, KDM1A, VDR, EED, BCL6, RARB, NR1H4, RARG, EHMT1, RXRA, TP53, SIRT5, TLE1, RB1, BRCA1, HDAC4, NCOA2, HDAC2, NR1I2, UBA3, MDM2, FABP4, SETD8, MDM4, HDAC8 2.05 0.00440251 0.500666
GOTERM_BP_FAT Negative regulation of nitrogen compound metabolic process 33 7.07 4.87E-04 PPARA, PPARD, THRA, THRB, TSG101, PPARG, COMT, NR1H2, VDR, KDM1A, EED, CDA, BCL6, RARB, NR1H4, RARG, EHMT1, RXRA, TP53, SIRT5, TLE1, RB1, BRCA1, HDAC4, NCOA2, HDAC2, NR1I2, UBA3, MDM2, FABP4, SETD8, MDM4, HDAC8 1.93 0.00683604 0.88072
GOTERM_BP_FAT Negative regulation of nucleobase, nucleoside, nucleotide, and nucleic acid metabolic process 32 6.85 8.13E-04 PPARA, PPARD, THRA, THRB, TSG101, PPARG, NR1H2, KDM1A, VDR, EED, CDA, BCL6, RARB, NR1H4, RARG, EHMT1, RXRA, TP53, SIRT5, TLE1, RB1, BRCA1, HDAC4, NCOA2, HDAC2, NR1I2, UBA3, MDM2, FABP4, SETD8, MDM4, HDAC8 1.90 0.0106896 1.465914
Annotation cluster 43 Enrichment score: 3.59
GOTERM_BP_FAT Positive regulation of nucleobase, nucleoside, nucleotide, and nucleic acid metabolic process 42 8.99 1.87E-05 NCBP1, PPARA, HRAS, THRA, THRB, ADORA2A, PPARG, ARNT, NR1H2, IGF1R, TNFRSF1A, APP, RARB, KDM5A, INSR, NR1H4, NR1H3, BCKDHA, AR, RARG, MAP2K1, EPAS1, TGFBR1, RXRA, ESRRG, TP53, IGF1, RB1, ESR2, CD40, PPARGC1A, BRCA1, CDK2, TNKS2, HDAC4, MAPK1, NCOA1, NCOA2, HDAC2, MAPK14, JAK3, IL2 2.04 5.12E-04 0.034005
GOTERM_BP_FAT Positive regulation of gene expression 37 7.92 1.99E-04 PPARA, THRA, THRB, PPARG, KIT, ARNT, NR1H2, TNFRSF1A, APP, RARB, KDM5A, NR1H4, NR1H3, BCKDHA, AR, RARG, EPAS1, TGFBR1, RXRA, ESRRG, TP53, ESR1, IGF1, RB1, ESR2, PPARGC1A, BRCA1, CDK2, HDAC4, MAPK1, NCOA1, NCOA2, HDAC2, MAPK14, MAPK9, JAK3, IL2 1.93 0.00342307 0.360451
GOTERM_BP_FAT Positive regulation of transcription from RNA polymerase II promoter 27 5.78 2.41E-04 PPARA, THRA, THRB, PPARG, ARNT, NR1H2, TNFRSF1A, APP, RARB, NR1H4, NR1H3, AR, RARG, EPAS1, RXRA, TP53, IGF1, RB1, ESR2, PPARGC1A, HDAC4, NCOA1, NCOA2, HDAC2, MAPK14, JAK3, IL2 2.21 0.00396061 0.437076
GOTERM_BP_FAT Positive regulation of RNA metabolic process 32 6.85 2.87E-04 PPARA, NCBP1, THRA, THRB, PPARG, ARNT, NR1H2, TNFRSF1A, APP, RARB, NR1H4, NR1H3, BCKDHA, AR, RARG, MAP2K1, EPAS1, RXRA, ESRRG, TP53, IGF1, RB1, ESR2, PPARGC1A, BRCA1, HDAC4, NCOA1, NCOA2, HDAC2, MAPK14, JAK3, IL2 2.02 0.00447801 0.519307
GOTERM_BP_FAT Positive regulation of transcription 34 7.28 9.92E-04 PPARA, THRA, THRB, PPARG, ARNT, NR1H2, TNFRSF1A, APP, RARB, KDM5A, NR1H4, NR1H3, BCKDHA, AR, RARG, EPAS1, RXRA, TGFBR1, ESRRG, TP53, IGF1, RB1, ESR2, PPARGC1A, BRCA1, CDK2, HDAC4, MAPK1, NCOA1, NCOA2, HDAC2, MAPK14, JAK3, IL2 1.83 0.01261501 1.785517
GOTERM_BP_FAT Positive regulation of transcription, DNA dependent 30 6.42 0.001113 PPARA, THRA, THRB, PPARG, ARNT, NR1H2, TNFRSF1A, APP, RARB, NR1H4, NR1H3, BCKDHA, AR, RARG, EPAS1, RXRA, ESRRG, TP53, IGF1, RB1, ESR2, PPARGC1A, BRCA1, HDAC4, NCOA1, NCOA2, HDAC2, MAPK14, JAK3, IL2 1.91 0.0137637 2.001185
Annotation cluster 44 Enrichment score: 3.57
GOTERM_BP_FAT Regulation of glucose metabolic process 8 1.71 1.20E-04 AKT1, HDAC4, IGF1, NR3C1, INSR, PPARGC1A, ARNT, AKT2 6.93 0.00225032 0.21798
GOTERM_BP_FAT Positive regulation of glucose metabolic process 6 1.28 2.99E-04 AKT1, IGF1, INSR, PPARGC1A, ARNT, AKT2 9.58 0.00461973 0.540924
GOTERM_BP_FAT Positive regulation of cellular carbohydrate metabolic process 6 1.28 3.88E-04 AKT1, IGF1, INSR, PPARGC1A, ARNT, AKT2 9.10 0.00566472 0.70135
GOTERM_BP_FAT Positive regulation of carbohydrate metabolic process 6 1.28 3.88E-04 AKT1, IGF1, INSR, PPARGC1A, ARNT, AKT2 9.10 0.00566472 0.70135
Annotation cluster 45 Enrichment score: 3.49
GOTERM_BP_FAT Positive regulation of cyclin-dependent prote in kinase activity during G1/S 4 0.86 1.38E-04 EGFR, AKT1, PIM1, ADAM17 30.33 0.00252379 0.25015
GOTERM_BP_FAT Regulation of cyclin- dependent protein kinase activity during G1/S 4 0.86 1.38E-04 EGFR, AKT1, PIM1, ADAM17 30.33 0.00252379 0.25015
GOTERM_BP_FAT Positive regulation of cyclin-dependent protein kinase activity 4 0.86 0.00175 EGFR, AKT1, PIM1, ADAM17 15.17 0.01988844 3.129
Annotation cluster 46 Enrichment score: 3.44
GOTERM_BP_FAT Regulation of lymphocyte proliferation 12 2.57 8.23E-05 CD38, PRKCQ, NCK2, CASP3, ERBB2, ZAP70, SFTPD, BCL6, CD40, PNP, IL2, SYK 4.39 0.00166731 0.149307
GOTERM_BP_FAT Regulation of mononuclear cell proliferation 12 2.57 9.20E-05 CD38, PRKCQ, NCK2, CASP3, ERBB2, ZAP70, SFTPD, BCL6, CD40, PNP, IL2, SYK 4.33 0.00183952 0.1668
GOTERM_BP_FAT Regulation of leukocyte proliferation 12 2.57 9.20E-05 CD38, PRKCQ, NCK2, CASP3, ERBB2, ZAP70, SFTPD, BCL6, CD40, PNP, IL2, SYK 4.33 0.00183952 0.1668
GOTERM_BP_FAT Positive regulation of cell activation 13 2.78 2.86E-04 TRAF2, PLEK, CD40, PNP, PRKCQ, NCK2, CD38, LCK, ZAP70, BCL6, TRAF6, SYK, IL2 3.55 0.00449264 0.518482
GOTERM_BP_FAT Positive regulation of lymphocyte activation 12 2.57 3.36E-04 TRAF2, CD38, PRKCQ, NCK2, LCK, ZAP70, BCL6, CD40, TRAF6, PNP, IL2, SYK 3.75 0.00504753 0.607989
GOTERM_BP_FAT Positive regulation of lymphocyte proliferation 9 1.93 4.03E-04 CD38, PRKCQ, NCK2, ZAP70, BCL6, CD40, PNP, IL2, SYK 4.96 0.0058375 0.729273
GOTERM_BP_FAT Positive regulation of mononuclear cell proliferation 9 1.93 4.57E-04 CD38, PRKCQ, NCK2, ZAP70, BCL6, CD40, PNP, IL2, SYK 4.87 0.00655668 0.826394
GOTERM_BP_FAT Positive regulation of leukocyte proliferation 9 1.93 4.57E-04 CD38, PRKCQ, NCK2, ZAP70, BCL6, CD40, PNP, IL2, SYK 4.87 0.00655668 0.826394
GOTERM_BP_FAT Positive regulation of leukocyte activation 12 2.57 7.21E-04 TRAF2, CD38, PRKCQ, NCK2, LCK, ZAP70, BCL6, CD40, TRAF6, PNP, IL2, SYK 3.43 0.00971853 1.300425
GOTERM_BP_FAT Regulation of T-cell proliferation 9 1.93 9.16E-04 PRKCQ, NCK2, CASP3, ERBB2, ZAP70, SFTPD, PNP, IL2, SYK 4.40 0.01184284 1.650107
GOTERM_BP_FAT Positive regulation of T-cell activation 9 1.93 0.003429 TRAF2, PRKCQ, NCK2, LCK, ZAP70, TRAF6, PNP, IL2, SYK 3.59 0.03453311 6.043888
Annotation cluster 47 Enrichment score: 3.30
GOTERM_BP_FAT Negative regulation of transferase activity 12 2.57 3.07E-04 PRKCA, AKT1, PPP2R1A, PDPK1, CASP3, HMGCR, ADORA2A, PPP2CA, PPARG, FABP4, RB1, SFN 3.79 0.00471957 0.555258
GOTERM_BP_FAT Negative regulation of protein kinase activity 11 2.36 5.57E-04 PRKCA, AKT1, PPP2R1A, PDPK1, CASP3, HMGCR, ADORA2A, PPP2CA, FABP4, RB1, SFN 3.84 0.00764671 1.006445
GOTERM_BP_FAT Negative regulation of kinase activity 11 2.36 7.30E-04 PRKCA, AKT1, PPP2R1A, PDPK1, CASP3, HMGCR, ADORA2A, PPP2CA, FABP4, RB1, SFN 3.71 0.00979929 1.316686
Annotation cluster 48 Enrichment score: 3.14
SP_PIR_KEYWORDS SH3 domain 16 3.43 1.94E-04 ITK, LYN, GRB2, HCK, NCF4, SRC, BTK, NCK2, TJP1, FYN, MAP3K9, LCK, TNK2, ABL1, ARHGAP9, DLG1 3.14 0.0015486 0.280714
UP_SEQ_FEATURE SH3 domain 14 3.00 4.16E-04 ITK, LYN, HCK, NCF4, SRC, BTK, TJP1, FYN, MAP3K9, LCK, TNK2, ABL1, ARHGAP9, DLG1 3.24 0.0157035 0.695681
INTERPRO Src homology-3 domain 16 3.43 9.74E-04 ITK, LYN, GRB2, HCK, NCF4, SRC, BTK, NCK2, TJP1, FYN, MAP3K9, LCK, TNK2, ABL1, ARHGAP9, DLG1 2.69 0.0206159 1.506777
SMART SH3 domain 16 3.43 0.003617 ITK, LYN, GRB2, HCK, NCF4, SRC, BTK, NCK2, TJP1, FYN, MAP3K9, LCK, TNK2, ABL1, ARHGAP9, DLG1 2.33 0.04574947 4.316077
Annotation cluster 49 Enrichment score: 3.06
GOTERM_BP_FAT Mononuclear cell proliferation 8 1.71 5.31E-04 ACE, CXCR4, FYN, BCL2, TP53, FKBP1A, CD40, HPRT1 5.51 0.00731779 0.959108
GOTERM_BP_FAT Leukocyte proliferation 8 1.71 5.31E-04 ACE, CXCR4, FYN, BCL2, TP53, FKBP1A, CD40, HPRT1 5.51 0.00731779 0.959108
GOTERM_BP_FAT Lymphocyte proliferation 7 1.50 0.002353 CXCR4, FYN, BCL2, TP53, FKBP1A, CD40, HPRT1 5.06 0.02523826 4.185354

Abbreviations: DAVID, Database for Annotation, Visualization, and Integrated Discovery; UA, ursolic acid; FDR, false discovery rate.