Fig 3. GABA input is required for neural desensitization of Or67d ORNs.

Effects of five neurotransmitter antagonists on the neural desensitization driven by the odor exposure were examined. The response changes after each CE were calculated by subtraction of values of relative fluorescent change of "Dosed before CE" from that "after CE" in individual flies (S5B–S5G Fig). Picrotoxin, CGP54626, Mecamylamine, MK801, and Butaclamol were used as antagonists of GABA_A, GABA_B, Nicotinic acetylcholine, NMDA, and dopamine receptors, respectively. Box plots represent 25th, 50th, and 75th percentiles with whiskers from minimum to maximum and mean with circles. Significant differences are denoted by *, P < 0.05; ns, not significant (Student's t-test). Experimental procedure including the drug application is referred in S5 Fig.