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. Author manuscript; available in PMC: 2015 Aug 7.
Published in final edited form as: J Physiol Paris. 2008 Oct 18;102(4-6):195–208. doi: 10.1016/j.jphysparis.2008.10.019

Fig. 6.

Fig. 6

Muscarinic receptor activation leads to an increase in burst firing and low-frequency response in vivo and in vitro. Carbachol increases burst discharge in vivo. (A) ISI histograms before, during, and after, application of carbachol. Carbachol leads to an increase in the number of ISIs shorter than 10 ms. (B) Bar graph representing the average increase of the burst fraction in vivo (fraction of ISIs < 10 ms; control: 0.11 ± 0.10; carbachol: 0.24 ± 0.15) following carbachol and return to control levels following recovery period. (C) In vitro application of carbachol induced a slow depolarization of ELL pyramidal cells, and is sufficient to drive them to fire spikes. (D) Atropine eliminates the carbachol induced depolarization observed in vitro, suggesting mAChR activation. (E) ISI histogram showing an increase in ISI’s < 10 ms following carbachol application in vitro. (F) An increase in the burst fraction is also observed in vitro (fraction of ISIs < 10 ms) after carbachol application. Modified from Ellis et al. (2007a).