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Resistance to crizotinib was investigated by western blot in Ba/F3 EML4-ALK cell lines. ALK phosphorylation status (Tyr1604) and total ALK expression levels were assessed after 4-h incubation with the indicated crizotinib concentrations. Actin was used as a loading control. ALK, anaplastic lymphoma kinase; NPM, nucleophosmin; EML4, echinoderm microtubule-associated protein-like 4.
