Table 2.
Cell lines | IC50 (μmol/L) | |||
---|---|---|---|---|
AP26113 | ASP3026 | Alectinib | Ceritinib | |
Ba/F3 | >1 | 5.964 | >10 | >1 |
Ba/F3 NA WT | 0.011 | 0.084 | 0.020 | 0.020 |
Ba/F3 NA C1156Y | 0.016 | 0.284 | 0.038 | 0.071 |
Ba/F3 NA L1196M | 0.030 | 0.682 | 0.032 | 0.042 |
Ba/F3 NA L1152R | 0.004 | 2.763 | 0.047 | 0.288 |
Ba/F3 NA G1202R | 0.149 | 1.177 | 0.549 | 0.277 |
Ba/F3 NA G1269A | 0.011 | 0.364 | 0.104 | 0.019 |
Ba/F3 NA S1206Y | 0.022 | 0.110 | 0.025 | 0.037 |
Ba/F3 | >1 | 5.964 | >10 | >1 |
Ba/F3 EA WT | 0.006 | 0.056 | 0.013 | 0.021 |
Ba/F3 EA C1156Y | 0.005 | 0.090 | 0.010 | 0.026 |
Ba/F3 EA L1196M | 0.008 | 0.141 | 0.022 | 0.019 |
Ba/F3 EA L1152R | 0.001 | 0.514 | 0.017 | 0.099 |
Ba/F3 EA G1202R | 0.325 | 1.210 | 0.868 | 0.467 |
Ba/F3 EA G1269A | 0.009 | 0.118 | 0.084 | 0.033 |
Ba/F3 EA S1206Y | 0.021 | 0.118 | 0.037 | 0.038 |
IC50, half maximal inhibitory concentration; NPM, nucleophosmin; ALK, anaplastic lymphoma kinase; EML4, echinoderm microtubule-associated protein-like 4; WT, wild type.