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Plasma microRNA expression assessing chemotherapy responsiveness in orthotopic OS model. Mice were injected intratibially with mouse OS cells and then randomized to receive placebo or doxorubicin. Statistically significant differences were assessed using a two-sample, two-tailed Student’s t-test comparing the 2−ΔCt values in each group compared to microRNA levels at randomization. (*P < 0.05).
