Figure 4.

Alterations of hormone receptors expression in mouse uteri after expose to E2. (A) PR expression increased after E2 exposure. At 6 weeks, loss of PR expression in the endometrial cells was observed. Diffused cytoplasmic expression was observed in atypical gland at 8 weeks after E2 exposure (black arrow). However, a complete loss of PR expression in some atypical hyperplastic glands occurred in 10 weeks group (black arrow). Myometrium served as an internal staining control and showed strong positive nuclear staining. M: myometrium. (B) ER expression in endometrium was significantly reduced after 4 weeks of E2 exposure and increased at 6 weeks. PR, progesterone receptor; ER, estrogen receptor.