Figure 5.

Leukocytic infiltration occurred as the glandular epithelium transformed to atypia. CD45+ cells were homogenously scattered throughout the endometrial stroma in normal nonproliferative endometrium. In the proliferative phase and nonatypical hyperplasia (6 weeks group), CD45+ cells increased in number, but still maintained their homogenous distribution. Penetrations of CD45+ cells into localized atypical glands occurred at 8 weeks of E2 exposure (black arrow). In atypical EH at 10 weeks, the number of CD45+ cells increased significantly, and the atypical glands were surrounded and penetrated by these cells.