. 2015 Mar 13;4(7):1060–1068. doi: 10.1002/cam4.449

Table 3.

Geometric mean (GM) pharmacokinetic parameters of IL-13-PE treatment

Dose	Cycle, day	No. of patients	C_max (ng/mL)			AUC_last (min·ng/mL)			AUC_0–∞ (min·ng/mL)			% AUC_extrap		t_1/2 (min)		V_z (mL)		CL (mL/min)
Dose	Cycle, day	No. of patients	GM	CV	GMR	GM	CV	GMR	GM	CV	GMR	GM	CV	GM	CV	GM	CV	GM	CV
1 μg/kg	C1D1	6	17.5	33.8	NA	1134	57	NA	1262	59	NA	9	36	30	78	3169	26	72	86
	C1D3	6	21	36.6	1.2	1410	51	1.24	1553	49	1.23	9	37	34	55	2917	21	59	82
	C2D1	2	11.7	79.9	0.67	665	92	0.59	836	79	0.66	15	87	36	15	7320	78	142	87
2 μg/kg	C1D1	2	41.2	19	NA	2963	41	NA	3089	41	NA	4	9	38	26	1153	31	21	55
2 μg/kg	C1D3	2	41.4	36.1	1	3374	34	1.14	3531	33	1.14	4	33	39	12	1068	37	19	47
1 μg/kg	All days	6	17.9	39.4	NA	1154	56	NA	1300	55	NA	9.8	61	33	60	3447	73	73	87
2 μg/kg	All days	2	41.3	23.8	2.31	3162	31	2.74	3303	31	2.54	4.2	21	38	16	1110	28	20	43.2

IL-13-PE, interleukin-13-Pseudomonas exotoxin; C_max, maximum serum concentration; t_1/2, terminal half-life; AUC_last, area under the curve from time 0 to last quantifiable time point; AUC_0–∞, area under the curve extrapolated from time 0 to infinity; % AUC_extrap, percentage AUC extrapolation; V_z, volume of distribution; CL, clearance; CV, coefficient of variation; GMR, geometric mean ratio; NA, not applicable.