Table 4.
Standardized incidence ratios and 95% CI for specific cancers other than testicular germ cell tumors (TGCT) occurring in first-degree male and female relatives of TGCT cases in Norway and the United States stratified by TGCT case or case family characteristics
| Stratification characteristic | PY | Overall | Soft tissue | Breast | Leukemia | ||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Obs | O/E | 95% CI | Obs | O/E | 95% CI | Obs | O/E | 95% CI | Obs | O/E | 95% CI | ||
| No. of TGCT cases in family | |||||||||||||
| 2 | 24,911 | 63 | 0.9 | 0.7–1.1 | 3 | 7.0 | 1.4–20.4 | 4 | 0.4 | 0.1–1.0 | 8 | 7.7 | 3.3–15.2 |
| ≥3 | 6641 | 21 | 1.0 | 0.6–1.6 | 1 | 7.7 | 0.2–42.9 | 2 | 0.6 | 0.1–2.3 | 1 | 2.9 | 0.1–15.9 |
| Histological type of TGCT in family | |||||||||||||
| Seminoma only | 9447 | 32 | 1.1 | 0.7–1.5 | 2 | 11.8 | 1.4–42.5 | 3 | 0.7 | 0.0–3.9 | 2 | 3.6 | 0.4–12.9 |
| Nonseminoma only | 5587 | 13 | 0.9 | 0.5–1.5 | 0 | 0.0 | 0.0–36.9 | 1 | 0.4 | 0.0–2.4 | 3 | 9.7 | 2.0–28.3 |
| Both seminoma and nonseminoma | 15,626 | 37 | 0.8 | 0.6–1.1 | 2 | 7.4 | 0.9–26.8 | 2 | 0.3 | 0.0–1.1 | 4 | 7.8 | 2.1–20.1 |
| Pattern of TGCT in family | |||||||||||||
| Siblings | 10,109 | 25 | 0.9 | 0.5–1.4 | 1 | 5.9 | 0.2–32.8 | 1 | 0.2 | 0.0–1.3 | 1 | 2 | 0.1–11.1 |
| Father/son | 4508 | 20 | 1.0 | 0.6–1.5 | 0 | 0.0 | 0.0–36.9 | 1 | 0.4 | 0.0–2.0 | 2 | 5.6 | 0.7–20.1 |
| Uncle/nephew | 7479 | 22 | 0.9 | 0.6–1.4 | 3 | 23.1 | 4.8–67.4 | 0 | 0.0 | 0.0–1.2 | 5 | 50.0 | 16.2–116.7 |
| Inheritance model | |||||||||||||
| Autosomal dominant | 6940 | 28 | 1.0 | 0.6–1.4 | 0 | 0.0 | — | 3 | 0.7 | 0.2–2.1 | 2 | 3.5 | 0.4–12.5 |
| Autosomal recessive | 14,874 | 28 | 0.8 | 0.5–1.1 | 1 | 4.2 | 0.1–23.2 | 3 | 0.5 | 0.1–1.6 | 1 | 1.7 | 0.0–9.4 |
| X-linked recessive | 6667 | 15 | 0.9 | 0.5–1.4 | 2 | 20 | 2.4–72.3 | 2 | 0.8 | 0.1–2.8 | 4 | 30.8 | 8.4–78.8 |
| Unclear inheritance | 4439 | 15 | 1.1 | 0.6–1.9 | 1 | 12.5 | 0.3–69.7 | 0 | 0.0 | — | 2 | 22.2 | 2.7–80.3 |
| Type of relation to nearest TGCT case | |||||||||||||
| Siblings | 17,634 | 33 | 0.9 | 0.6–1.2 | 2 | 8.0 | 1.0–28.9 | 4 | 0.7 | 0.2–1.7 | 4 | 8.9 | 2.4–22.8 |
| Parents | 8409 | 51 | 0.9 | 0.7–1.2 | 2 | 7.7 | 0.9–27.8 | 2 | 0.3 | 0.0–0.9 | 4 | 4.7 | 1.3–12.1 |
Statistically significant results (nominal P-value <0.05) are shown in bold type. PY, person-years at risk; Obs, number observed; O/E, ratio of observed to expected; CI, confidence interval.