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. 2015 Apr 29;4(7):1079–1090. doi: 10.1002/cam4.451

Figure 1.

Figure 1

Aberrant methylation in NPC and other types of solid tumors. (A) Percentage of hypermethylated and hypomethylated CpG sites identified by LIMMA analysis with FDR < 0.001 in NPC and other types of solid tumors. hypo: hypomethylated CpG sites, hyper: hypermethylated CpG sites. (B) Categories of the genomic locations of de novo methylated CpG sites in NPC. Island: CpG island, N_Shelf: north shelf region of CGI, N_shore: north shore region of CGI, S_Shelf: south shelf region of CGI, N_Shelf: north shelf region of CGI. (C) Verification of the aberrant methylation of six selected loci identified in NPC by bisulfite pyrosequencing. 100% methylation control; 0% no methylation control; N: normal adjacent tissues, T: NPC tumor tissues. *Methylation level in tumor is significantly higher than matched nontumor tissue examined by Mann–Whitney U-test with P < 0.05. NPC, nasopharyngeal carcinoma; FDR, false discovery rate; CGI, CpG island.