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. 2015 Apr 29;4(7):1079–1090. doi: 10.1002/cam4.451

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© 2015 The Authors. Cancer Medicine published by John Wiley & Sons Ltd.

This is an open access article under the terms of the Creative Commons Attribution License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited.

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Aberrantly methylated regions identified in NPC and other types of solid tumors. (A) Aberrantly methylated regions across genome in NPC. Enrichment of the genes from 6p21.3 was identified by DAVID analysis. (B) Aberrantly methylated regions on 6p22.1-6p21.3 in NPC. Gray dots: the regions not reaching the significance level. Yellow dots: the regions reaching the significance level and which were unmethylated in normal adjacent tissues. The genes close to these regions are highlighted on the graph. Black dots: the regions reaching the significance level, but were methylated in normal adjacent tissues. (C) Aberrantly methylated regions in EBV-positive gastric cancer compared to EBV-negative gastric cancer. Enrichment of the genes from 6p21.3 was identified by DAVID analysis. (D–F) Aberrantly methylated regions in colon, kidney, and pancreatic cancers. No enrichment of the genes from 6p21.3 was observed. NPC, nasopharyngeal carcinoma; EBV, Epstein–Barr virus.