Table2.

Stability evaluation of EFdA plus CSIC combination films^a

Time	Puncture Strength (kg/mm)	Moisture Content (%)	Drug Content		Dissolutionb		Antiviral (EC50) (nM)
			EFdA (mg/Film)	CSIC (mg/Film)	EFdA (%)	CSIC (%)
25°C/65% R.H.
0 day	8.5 ± 1.1	6.6 ± 1.0	1.0 ± 0.02	1.1 ± 0.02	100 ± 2	100 ± 5	1.8 ± 0.2
1 M	9.9 ± 0.3	6.2 ± 0.1	1.0 ± 0.1	1.2 ± 0.1	98 ± 1	98 ± 5	1.7 ± 0.1
2 M	9.5 ± 0.8	6.8 ± 0.4	1.0 ± 0.1	1.1 ± 0.1	97 ± 3	97 ± 6	1.9 ± 0.2
3 M	8.4 ± 0.4	7.1 ± 0.2	1.0 ± 0.1	1.1 ± 0.01	100 ± 2	94 ± 5	2.0 ± 0.5
40°C/75% R.H.
0 day	8.5 ± 1.1	6.6 ± 1.0	1.0 ± 0.02	1.1 ± 0.02	100± 2	100 ± 5	1.8 ± 0.2
1 M	8.3 ± 0.1	6.4 ± 0.04	1.0 ± 0.03	1.1 ± 0.02	97 ± 0.5	102 ± 2	1.9 ± 0.3
2 M	8.6 ± 1.0	7.0 ± 0.2	1.0 ± 0.1	1.1 ± 0.06	95 ± 3	94 ± 4	2.5 ± 0.5
3 M	8.6 ± 1.0	7.3 ± 0.5	1.0± 0.04	1.1 ± 0.06	98 ± 5	95 ± 6	2.2 ± 0.6

^a: Mean ± SD of three determinations

^b: Dissolution at 60 min